Protective role of DLa-lipoic acid against adriamycin-induced cardiac lipid peroxidation

Balachandar, Andithangal Venkatesan; Malarkodi, Kumaravel Palanichamy; Varalakshmi, P.

doi:10.1191/0960327103ht358oa

Cited by 26 publications

(22 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cytoprotective effects of antioxidants against DOX is usually associated with the inhibition of lipid peroxidation, regardless of the type and structure of antioxidant. 16,[42][43][44][45] Although the active antioxidants in PU extract have not been identified, its suppression of lipid peroxide formation warrants further investigation.…”

Section: )mentioning

confidence: 99%

Antioxidative and Cardioprotective Effects of Phyllanthus urinaria L. on Doxorubicin-Induced Cardiotoxicity

Chularojmontri

Wattanapitayakul

Herunsalee

et al. 2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Doxorubicin (DOX) is an effective and broadly used agent to treat a variety of malignacies, such as leukemias, breast and ovarian cancer, and Hodgkin and non-Hodgkin lymphoma. The major limitation of clinical use is the development of cardiotoxicity. The adverse effects are dose dependent and can vary from transient electrocardiographic abnormalities to cardiomyopathy and heart failure. Recent studies have suggested that the mechanism of DOX-induced cardiotoxicity involves the generation of reactive oxygen species (ROS), especially superoxide anion and hydrogen peroxide.1-3) The main cellular damage caused by ROS includes lipid peroxidation, protein cross-linking, and DNA fragmentation. These may lead to cardiac dysfunction, apoptosis, and development of cardiomyopathy. 4-7)Although protection or alleviation of DOX toxicity can be achieved by administration of antioxidant vitamins such as ascorbic acid and vitamin E, their cardioprotective effects remain controversial. [8][9][10] It is well established that there is no universal "best" antioxidant. For example, ascorbic acid efficiently protects against lipid damage but not against protein damage.11) Thus alternative naturally occurring antioxidants may potentially be candidates for antioxidant therapy.It has been shown in many studies that traditionally used plant extracts protect against oxidative damage caused by a wide array of insults including DOX.12-16) Among traditional herbs, Phyllanthus spp. (Euphorbiaceae) has been used in Aryuvedic medicine for more than 2000 years and in Thai folk medicine for the treatment of many diseases, such as diarrhea, hepatitis, diabetes, abdominal pain, and kidney disease. 17,18) The antioxidant effects of plant species in the genus Phyllanthus have been reported. For example, Phyllanthus amarus (synonym: Phyllanthus niruri) reduced oxidative damage from radiation 19) and protected against hepatotoxicity induced by CCl 4 . 20) Phyllanthus emblica protected rat hearts from oxidative stress induced by ischemic-reperfusion injury.21) Phyllanthus urinaria L. is another medicinal plant that has attracted research attention in the treatment of several diseases. Substantial progress in determining its phytochemical and pharmacologic properties has been made. Several potential antioxidant compounds (e.g., polyphenols, lignans, flavonoids, gallic acid, ellagic acid, etc.) have been isolated from this plant. [22][23][24][25][26] However, to the best of our knowledge, there has been no report on the potential antioxidant effects of Phyllanthus urinaria. Therefore the purpose of this study was to investigate the antioxidant effects of Phyllanthus urinaria for the protection of cardiac cells from DOX cardiotoxicity. Cardiac toxicity is a major adverse effect caused by doxorubicin (DOX) therapy. Many recent studies have shown that DOX toxicity involves generation of reactive oxygen species (ROS). Although protection or alleviation of DOX toxicity can be achieved by administration of antioxidant vitamins such as ascorbic acid and vitamin ...

show abstract

Section: )mentioning

confidence: 99%

Antioxidative and Cardioprotective Effects of Phyllanthus urinaria L. on Doxorubicin-Induced Cardiotoxicity

Chularojmontri

Wattanapitayakul

Herunsalee

et al. 2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…α-LA has been shown by many studies, both in vivo and in vitro, to decrease lipid peroxidation levels. Reduced lipid peroxidation following α-LA administration has been observed to be associated with a protective effect against adriamycin-induced nephrotoxicity and cardiotoxicity in rats (34,35). Additional studies have found that α-LA treatment results in a decreased MDA level in the plasma (36), liver, kidney (17) and different regions of the brain (37).…”

Section: Discussionmentioning

confidence: 95%

“…Many studies have investigated the effects of α-LA on antioxidant enzymes (35,36). Maritim et al (38) reported that α-LA administration reduced oxidative stress and altered SOD, CAT, and GSH-Px enzymatic activity levels in the liver, kidney, and heart in rats.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Alpha-Lipoic Acid on Oleic Acid-Induced Acute Lung Injury in Rats

et al. 2013

View full text Add to dashboard Cite

Background: Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI).Aims: The aim of this study was to investigate the possible protective role of alpha-lipoic acid (α-LA) on oleic acid (OA)-induced ALI in rats.Study Design: Animal experiment.Methods: A total of thirty-five rats were divided into five groups in the study. Group 1 served as a control group. Rats in Group 2 (α-LA) were administered α-LA intraperitoneally at a dose of 100 mg/kg body weight (BW). Rats in Group 3 (OA) were administered OA intravenously at a dose of 100 mg/kg BW. In Group 4 (pre-OA-α-LA), α-LA was given 15 minutes prior to OA infusion, and in Group 5 (post-OA-α-LA), α-LA was given two hours after OA infusion. Four hours after the OA infusion, rats were decapitated. Blood samples were collected to measure serum levels of malondialdehyde (MDA) and glutathione (GSH), and the levels of activity for superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Lung tissue samples were taken for histopathological examination.Results: Exposure to OA resulted in increases in serum MDA levels (p<0.001), as well as histopathological lesions in lung tissue, and decreases in CAT (p<0.05), GSH-Px (p<0.05) activities and GSH (p<0.05) levels. On the other hand, MDA levels were decreased significantly (p<0.001), while CAT (p<0.05), GSH-Px (p<0.01) activities and GSH (p<0.05) levels were increased significantly in the pre-OA-α-LA group compared with the OA group.Conclusion: α-LA was found to lessen oxidative stress and to have positive effects on antioxidants in cases of OA-induced ALI. In conclusion, α-LA appears to have protective effects against ALI and potential for the prevention of ALI.

show abstract

“…In the literature, in a study carried out with the rat sepsis model, lipoic acid was shown to be able to prevent neutrophil accumulation through reducing the oxidative stress, after which lipid peroxidation increased as a result of oxidative stress, and that lipoic acid reduced the lipid peroxidation in the lungs (29). In three different studies carried out parallely, lipoic acid was reported to significantly reduce the increased lipid peroxidation (30)(31)(32). In another study, the cerebral free radical amount and the effects of reperfusion were shown to decrease through lipoic acid administration to the animals which had been exposed to ischemic reperfusion induced through cerabral artery clamping (21).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Alpha Lipoic Acid and Vitamin C on Colonic Anastomosis in the Rat Sepsis Model

et al. 2014

View full text Add to dashboard Cite

show abstract

Protective role of DLa-lipoic acid against adriamycin-induced cardiac lipid peroxidation

Cited by 26 publications

References 41 publications

Antioxidative and Cardioprotective Effects of Phyllanthus urinaria L. on Doxorubicin-Induced Cardiotoxicity

Antioxidative and Cardioprotective Effects of Phyllanthus urinaria L. on Doxorubicin-Induced Cardiotoxicity

Protective Effects of Alpha-Lipoic Acid on Oleic Acid-Induced Acute Lung Injury in Rats

Comparison of the Effects of Alpha Lipoic Acid and Vitamin C on Colonic Anastomosis in the Rat Sepsis Model

Contact Info

Product

Resources

About