Protective Role of Dexmedetomidine on Ileum and Kidney Damage Caused by Mesenchymal Ischaemia in Rats

Sancaktar, Nuray Çakır; Altınbaş, Ali; Çekiç, Bahanur

doi:10.5152/tjar.2018.46244

Cited by 6 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In ischemia-reperfusion injury and oxidative stress studies with DEX it has been reported that DEX has a histopathological improvement effect and regression effect in damaged tissues of dif-ferent organs (29,30). In an experimental study, Sancaktar et al reported that there was a signifi cant decrease in renal apoptotic index in the DEX group compared to the I/R damage group (29). Again Chen et al showed that use of DEX reduces apoptosis in cardiopulmonary bypass related neuronal apoptosis (31).…”

Section: Discussionmentioning

confidence: 99%

Acute acetaminophene-induced hepatotoxicity and nephrotoxicity; therapeutic effect of dexmedetomidine

Taş¹,

Altınbaş²,

Noyan³

et al. 2019

BLL

View full text Add to dashboard Cite

OBJECTIVE AND BACKGROUND: Acute acetaminophen (APAP) overdose has been shown to cause toxicity and the primary treatment medication is N-acetylcysteine (NAC). Dexmedetomidine (DEX) is a sedative drug with known antioxidant properties. We researched whether DEX has an injury-reducing effect on toxicity. METHODS: Rats were divided into: Group I (control), Group II (APAP) Group III (NAC) Group IV (DEX) and Group V (NAC+DEX). Histopathologic investigations of tissues were performed and glutathione peroxidase (GSH-Px), catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO) and beta trace protein (PGD2S) levels were studied in blood samples. RESULTS: DEX administration for hepatotoxicity and nephrotoxicity induced with APAP, caused a signifi cant reduction in oxidative injury markers like MDA and MPO, a signifi cant increase in GSH-Px level and a signifi cant degree of amelioration in liver histopathologic scores. CONCLUSION: DEX administration for APAP toxicity causes a reduction in oxidative injury biomarkers, increased antioxidant biomarker levels and signifi cant reduction in liver histopathologic scores. The benefi cial effect of DEX use for detection of toxicity induced by acute APAP overdose, was shown in this study for the fi rst time (Tab. 5, Fig. 2, Ref. 41).

show abstract

Section: Discussionmentioning

confidence: 99%

Acute acetaminophene-induced hepatotoxicity and nephrotoxicity; therapeutic effect of dexmedetomidine

Taş¹,

Altınbaş²,

Noyan³

et al. 2019

BLL

View full text Add to dashboard Cite

show abstract

“…9,10,15 This protection was conferred through multiple signalling molecules and pathways, including NF-κB, ERK1/2, Nrf2, JAK2/STAT3 and p38/NO, all of which are directly or indirectly regulated by α 2 -AR. However, a high concentration (50 nM) of Dex conversely promoted DDP-induced toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…In most previous studies, Dex was found to confer protection against anti-cancer drugs, hypoxia and ischaemic/reperfusion injury in multiple cell lines. 9,10,15 This protection was conferred through multiple signalling molecules and pathways, including NF-κB, ERK1/2, Nrf2, JAK2/STAT3 and p38/NO, all of which are directly or indirectly regulated by α 2 -AR. Previous studies have reported that α 2 -AR-mediated inhibition of NF-κB is responsible for Dex protection against DDP toxicity in kidneys.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 Protection by Dex appears to be primarily dependant on α 2 -adrenergic activation, as blocking the α 2 -AR abolishes these protective effects. Dex is popular not only for its synergistic anaesthetic effect with other anaesthetics, but also for the strong protection against tissue injury and function impairment it provides.…”

Section: Introductionmentioning

confidence: 99%

“…Dex is popular not only for its synergistic anaesthetic effect with other anaesthetics, but also for the strong protection against tissue injury and function impairment it provides. 9,10 Protection by Dex appears to be primarily dependant on α 2 -adrenergic activation, as blocking the α 2 -AR abolishes these protective effects. 11 α 2 -AR is a G i -type G proteincoupled receptor that reduces intracellular cyclic AMP (cAMP) levels.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of dexmedetomidine on glioma cells in the presence or absence of cisplatin

Yang

Chen

Yan

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

With the extensive use of dexmedetomidine (Dex) in the surgical resection of tumours for its potent sedative and analgesic properties, its effects on various properties of tumours have received increased attention. The study described herein aimed to investigate the effects of Dex on glioma cells in the presence or absence of cisplatin (DDP). Glioma U251 and U87MG cells were treated with different doses (1‐50 nM) of Dex for 12 hours, then recultured in a Dex‐free medium. In addition, Dex was added to U251 and U87MG cells 12 hours before or simultaneously with a 12‐hour DDP treatment. Treatment with Dex increased the viability of both cell lines; this effect continued for at least 24 hours after Dex was removed. A cell invasion assay indicated that Dex inhibited cell invasion at 50 nM, but not at 10 nM. Western blot analysis showed that Dex increased the expression of phosphorylated extracellular‐signal‐regulated kinase 1/2, phosphoitide 3‐kinase and p‐AKT, but decreased ROCK protein levels at a dose of 50 nM. Intracellular Ca 2+ concentration was decreased by Dex in a dose‐dependent manner. DDP toxicity was attenuated by 10 nM Dex added either before or with DDP treatment. However, pretreatment with 50 nM Dex instead enhanced the toxicity of DDP. Single‐dose treatment with Dex did not significantly change glioma volume in nude mice, but changed the expression of Ki67 and matrix metalloproteinase‐3 in the tumour. In conclusion, this study provides evidence of the regulatory effects of Dex on proliferation, invasion and chemosensitivity of glioma cells, and outlines potential mechanisms for these effects.

show abstract

Which Distant Organ is Most Affected by Lower Extremity Ischemia-Reperfusion?

Gokalp

Eygi

Gökalp

et al. 2020

Annals of Vascular Surgery

View full text Add to dashboard Cite

Protective Role of Dexmedetomidine on Ileum and Kidney Damage Caused by Mesenchymal Ischaemia in Rats

Abstract: the manuscript, references should be cited using Arabic numbers in parentheses. The reference styles for different types of publications are presented in the following examples.

Cited by 6 publications

References 28 publications

Acute acetaminophene-induced hepatotoxicity and nephrotoxicity; therapeutic effect of dexmedetomidine

Acute acetaminophene-induced hepatotoxicity and nephrotoxicity; therapeutic effect of dexmedetomidine

Effects of dexmedetomidine on glioma cells in the presence or absence of cisplatin

Which Distant Organ is Most Affected by Lower Extremity Ischemia-Reperfusion?

Contact Info

Product

Resources

About