Protective role of cytosolic prion protein against virus infection in prion-infected cells
Hideyuki Hara,
Junji Chida,
Batzaya Batchuluun
et al.
Abstract:Production of the amyloidogenic prion protein, PrP
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, which forms infectious protein aggregates, or prions, is a key pathogenic event in prion diseases. Functional prion-like protein aggregations, such as the mitochondrial adaptor protein MAVS and the inflammasome component protein ASC, have been identified to play a protective role in viral infections in mammalian cells. In this study, to investigate if PrP
Sc
could play a functional role against exter… Show more
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