2008
DOI: 10.1161/circresaha.107.160697
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Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

Abstract: Abstract-The CXC ligand (CXCL)12/CXC receptor (CXCR)4 chemokine-receptor axis controls hematopoiesis, organ development, and angiogenesis, but its role in the inflammatory pathogenesis of atherosclerosis is unknown. Here we show that interference with Cxcl12/Cxcr4 by a small-molecule antagonist, genetic Cxcr4 deficiency, or lentiviral transduction with Cxcr4 degrakine in bone marrow chimeras aggravated diet-induced atherosclerosis in apolipoprotein E-deficient (Apoe Ϫ/Ϫ ) or LDL receptor-deficient (Ldlr Ϫ/Ϫ ) … Show more

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Cited by 373 publications
(333 citation statements)
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References 53 publications
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“…In the early stages of atherosclerosis the neutrophil plays a key role, through the release of specific chemoattractant mediators, in the consequent recruitment of inflammatory monocytes to the athero-prone site (44,63). Using an acute model of inflammation, we have shown that treatment of ApoE KO mice with inorganic nitrate reduces first neutrophil recruitment, followed by consequent reductions in the number of inflammatory monocytes.…”
Section: (B) the Same Pattern Was Observed In Erythrocytes (G And H)mentioning
confidence: 94%
“…In the early stages of atherosclerosis the neutrophil plays a key role, through the release of specific chemoattractant mediators, in the consequent recruitment of inflammatory monocytes to the athero-prone site (44,63). Using an acute model of inflammation, we have shown that treatment of ApoE KO mice with inorganic nitrate reduces first neutrophil recruitment, followed by consequent reductions in the number of inflammatory monocytes.…”
Section: (B) the Same Pattern Was Observed In Erythrocytes (G And H)mentioning
confidence: 94%
“…Although the pathophysiological significance of these cells during atherogenesis has not yet been well documented, it is suggested that these cells are pro-atherogenic [73]. Neutrophils play a major role in the development of many forms of vasculitis [74,75].…”
Section: Pathophysiology Of Accelerated Atherosclerosis In Vasculitismentioning
confidence: 99%
“…Our data suggest that higher logSDF-1α levels and lower CXCR4 expression in PBMCs are accompanied by higher leukocyte, neutrophil, and lymphocyte counts in PB from male and female BHLP patients. However, lower logSDF-1α levels are accompanied by lower leukocyte and neutrophil counts in PB in male HLP patients (Zernecke et al 2008). Other investigators have reported that TNF-1α activation results in leukocyte recruitment and may explain the leukocytosis observed in patients with hypercholesterolemia (Han et al 1999;Steinberg 2002;Bobryshev 2006).…”
Section: Discussionmentioning
confidence: 95%
“…Moreover, in patients with either stable or unstable angina, there was decreased surface expression, but increased gene expression, in peripheral blood mononuclear cells (PBMCs) of the SDF-1α receptor CXCR4. SDF-1α may, therefore, exert a protective effect against atherogenesis (Damås et al 2002;Zernecke et al 2008).…”
mentioning
confidence: 99%