Protective role of curcumin on colchicine-induced cognitive dysfunction and oxidative stress in rats

Abstract

Dementia is a syndrome of progressive nature, affects wide range of cognitive abilities like memory, language, calculation and so on, neuropsychiatric and social deficits to impair the routine social functions. The present study was designed to assess the effect of curcumin against colchicine-induced cognitive dysfunction and oxidative stress in rats and compare it with rivastigmine. Colchicine (15 µg/5µl) was administered to male Wistar rats intracerebroventricularly (i.c.v.) by stereotaxic apparatus to induce cognitive dysfunction. Administration of colchicine caused poor retention of memory in elevated plus maze, passive avoidance apparatus and Morris water maze paradigms. Chronic treatment with curcumin (100, 200 and 400 mg/kg, p.o.) twice daily and rivastigmine (2.5 mg/kg, p.o.) daily for a period of 28 days beginning 7 days prior to colchicine injection significantly improved colchicine-induced cognitive impairment. Biochemical assessment revealed that i.c.v. colchicine injection significantly increased lipid peroxidation, depleted reduced glutathione levels and decreased acetyl cholinesterase (AChE) activity in rat brains. Chronic administration of curcumin significantly reduced the elevated lipid peroxidation, restored the reduced glutathione levels and AChE activity; however, rivastigmine failed to prevent oxidative stress. The results of the current study indicate that curcumin (100, 200 and 400 mg/kg, p.o.) twice daily has a protective role against colchicine-induced cognitive impairment and associated oxidative stress.

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain

“…Previous studies have reported that curcumin decreases AChE activity in rat brain [51][52][53]. In vitro experiments also confirmed that curcumin inhibits AChE activity and has an IC 50 value of 67 µmol/L [54].…”

Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

“…Curcumin, a recognized pleiotropic natural compound is earmarked with strong potential to treat AD initially based on the epidemiological evidence in Indian population whereby long-term consumption of curcumin showed a 4.4 fold reduced incidence rate of AD compared to the USA [35]. Since then, compelling evidences from in vitro , in vivo and pre-clinical studies have systemically removed traces of lingering doubts regarding the therapeutic effect of curcumin in AD [17, 39, 40, 245-249]. Out of 214 anti-oxidant compounds tested in preventing fibrils formation, curcumin demonstrated the strongest inhibitory effect (IC 50 = 0.25 μg/mL) [36].…”

“…Pre-treated rats with curcumin (100, 200 and 400 mg/kg twice a day) for a period of 28 days before induction with colchicines showed improved protection against colchicines-induced cognitive impairment by improving the glutathione levels and AChE activities as well as reducing lipid peroxidation in colchicine-treated rats. Surprisingly, the ability of curcumin to control colchicines-induced cognitive impairment specifically in terms of protecting against oxidative stress seemed more potent than rivastigmine [318]. …”

Curcumin alleviates cisplatin-induced learning and memory impairments

“…The protective effect of curcumin against cisplatin-induced cognitive impairment and oxidative stress may be attributed to its antioxidant properties. In recent studies, the investigators have also reported the neuroprotective features of curcumin in various situations which are associated with the oxidative stress and cognitive impairment such as colchicines(Khurana et al, 2012), cigarette smoke(Jaques et al, 2012),…”