Protective Role of Catechin and Quercetin in Sodium Benzoate-Induced Lipid Peroxidation and the Antioxidant System in Human Erythrocytes<i>In Vitro</i>

Yetük, Gamze; Pandır, Dilek; Baş, Hatice

doi:10.1155/2014/874824

Cited by 37 publications

(20 citation statements)

References 40 publications

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“…Both resveratrol and quercetin are able to reduce ROS concentrations in different tissues [ 44 – 46 ], and their dietary supplementation increases CAT, SOD, and GPX expression [ 47 – 49 ]. Thanks to its high concentrations of polyphenols, RW consumption reduces LDL oxidation and prevents endothelial dysfunction [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial

Renzo

Cioccoloni

Salimei

et al. 2018

Oxidative Medicine and Cellular Longevity

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Background Noncommunicable diseases (NCDs) are the first cause of death worldwide. Mediterranean diet may play a crucial role in the prevention of NCDs, and the presence of wine in this diet could play a positive role on health. Methods 54 healthy volunteers consumed one of the following beverages: red (RW) or white wine (WW), vodka (VDK), and/or Mediterranean meal (MeDM) and high-fat meal (HFM). Results OxLDL-C changed significantly between baseline versus HFM, MeDM versus HFM, and HFM versus HFM + RW (p < 0.05). Significant upregulation of catalase (CAT) was observed only after RW. Conversely, WW, VDK, RW + MeDM, HF + WW, and HF + VDK determined a significant downregulation of CAT gene. Superoxide dismutase 2 (SOD2) gene expression was upregulated in WW, MeDM + VDK, and RW. Contrariwise, HFM + VDK determined a downregulation of its expression. RW, RW + MeDM, and RW + HFM caused the upregulation of glutathione peroxidase-1 (GPX1). Conclusions Our results suggest that the association of low/moderate intake of alcohol beverages, with nutraceutical-proven effectiveness, and ethanol, in association with a Mediterranean diet, could determine a reduction of atherosclerosis risk onset through a positive modulation of antioxidant gene expression helping in the prevention of inflammatory and oxidative damages.

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Section: Discussionmentioning

confidence: 99%

Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial

Renzo

Cioccoloni

Salimei

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…These observations could explain findings of this study that revealed significant accumulation of elastic fibers around the bronchiole, walls of the alveoli, and wall of the congested blood vessel together with marked increase in the alveolar wall thickness in lung tissues of DENPs exposed rat group. These findings could also be attributed to activation of immune cells by reactive oxygen species (ROS) and reactive nitrogen species (RNS) which initiate pulmonary fibrosis as proved in the previous study conducted by Yetuk et al [28]. One of the key inducers of inflammatory responses is NFK-B (26).…”

Section: Discussionmentioning

confidence: 83%

Effects of Mesenchymal Stem Cells and Their Derived Microvesicles on Pulmonary Toxicity Induced by Petrol Exhaust Nanoparticle; Histological and Immuno-Histochemical Study

Salam¹,

Faruk²,

Fouad³

et al. 2019

ARRB

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Background: Diesel vehicles exhaust contains toxic nanoparticles that drastically affect lung tissue due to their direct cytotoxic effects, induction of oxidative stress, inflammatory signaling pathways and DNA damage. Mesenchymal stem cells (MSCs) exhibit anti-inflammatory effects and efficient regenerative capacity in chronic lung diseases. Objectives: Evaluation of the effects of MSCs and MSCs-derived micro vesicles (MSCs-MVs) on pulmonary toxicity induced by diesel exhaust nanoparticles (DENPs). Materials and Methods: Sixty male rats were equally divided into: Group I (Control rats), Group II (DENPs group) received repeated doses of DENPs (180μg/rat) intratracheally every other day for 6 days, Group III (MSCs group) received MSCs intravenously (3×106 cells) after the last dose of DENPs and Group IV (MSCs-MVs group) received MSCs-MVs (0.5 mg/mL) intravenously after the last dose of DENPs. Lung tissue were subjected to histological and immunohistochemical assessment. Inflammatory cytokines and bronchoalveolar lavage fluid (BALF) contents of inflammatory cells, albumin, LDH and total proteins were evaluated. Results: Histological picture of lung tissue in DENPs group showed numerous collapsed alveoli, thick interalveolar septa and marked cellular infiltration. Elastic fibers were markedly decreased by DENPs. Increased optical density of NF-κB/p65 immunoreactivity. Bronchoalveolar lavage fluid showed significant elevation of inflammatory cytokines (TNF-a, IL-6), polymorphonuclear leukocytes (PMN), neutrophils, macrophages, LDH, total proteins and albumin. Treatment with either MSCs or MSCs-MVs led to a significant amelioration of all of the aforementioned studied parameters. Conclusion: MSCs-MVs and MSCs showed significant therapeutic effects against DENPs damaging effects on the lung tissues via their regenerative capacity and anti-inflammatory effects.

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“…As an inducer of ROS generation in PBMCs culture, hydrogen peroxide was used in the concentration of 1.0 mM. For the experiments, in vitro effective doses of free radical scavengers according to data from published reports were utilized: N-acetyl-cysteine (NAC) 30 nM [51], caffeic acid (30 µg/mL) [52,53], p-coumaric acid (160 µg/mL) [54], gallic acid (70 µg/mL) [55], quercetin (33.8 µg/mL) [56,57], ascorbic acid (80 µg/mL) [58,59], lipoic acid (10.3 µg/mL) [60], polydatin (10 µg/mL) [61], and tocopherol (Vitamin E) (115 µg/mL) [62,63]. The EACA was used in the same concentration as for the main experiments (50 ng/mL) with radiation.…”

Section: Tests For Free Radical Scavenging Activitymentioning

confidence: 99%

A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid

et al. 2020

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Background and objectives: The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. Materials and Methods: Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing radiation at three low doses (22.62 mGy, 45.27 mGy, and 67.88 mGy) in the presence of EACA at the concentration of 50 ng/mL. Results: EACA was able to prevent cell death induced by low-dose X-ray radiation and suppress the formation of reactive oxygen species (ROS). EACA also demonstrated a capacity to protect DNA from radiation-induced damage. The data indicated that EACA is capable of suppression of radiation-induced apoptosis. Comparative tests of antioxidative activity of EACA and a range of free radical scavengers showed an ability of EACA to effectively inhibit the generation of ROS. Conclusions: This study showed that the pretreatment of PBMCs with EACA is able to protect the cells from radiation-elicited damage, including free radicals’ formation, DNA damage, and apoptosis.

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Protective Role of Catechin and Quercetin in Sodium Benzoate-Induced Lipid Peroxidation and the Antioxidant System in Human ErythrocytesIn Vitro

Cited by 37 publications

References 40 publications

Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial

Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial

Effects of Mesenchymal Stem Cells and Their Derived Microvesicles on Pulmonary Toxicity Induced by Petrol Exhaust Nanoparticle; Histological and Immuno-Histochemical Study

A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid

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