Protective role of caffeic acid phenethyl ester in the liver of rats exposed to cold stress

Ateş, Burhan; Dogru, M. I.; Gül, Mehmet; Erdoğan, Ali; Doğru, Arzu; Yılmaz, İsmet; Yürekli, Muhittin; Eşrefoğlu, Mukaddes

doi:10.1111/j.1472-8206.2006.00402.x

Cited by 43 publications

(48 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Heat stress increased lipid peroxidation as a consequence of increased free radical generation. The rise of lipid peroxidation increases the MDA level in blood and tissues (Okutan et al 2005;Ates et al 2006). In this study, it was found that plasma, liver and muscle MDA levels were significantly decreased in positive control, vitamin C and EEP-3 groups compared to those in the control.…”

Section: Discussionmentioning

confidence: 60%

Effects of Propolis on Selected Blood Indicators and Antioxidant Enzyme Activities in Broilers under Heat Stress

et al. 2009

View full text Add to dashboard Cite

In this study, we investigated the antioxidant activity of ethanol extracts of propolis (EEP) and vitamin C on biochemical indicators and antioxidant enzyme activities of broilers exposed to heat stress (at 34 °C). The experimental groups were as follows: group I (positive control) and group II (control) were fed a basal diet, group III (vitamin C) was fed a basal diet supplemented with 250 mg vitamin C as ascorbic acid/kg, group IV (EEP-0.5) was fed a basal diet supplemented with 0.5 g EEP/kg, group V (EEP-1) was fed a basal diet supplemented with 1 g EEP/kg, group VI (EEP-3) was fed a basal diet supplemented with 3 g EEP/kg. Plasma superoxide dismutase levels of positive control, control, vitamin C, EEP-0.5, EEP-1 and EEP-3 groups were found as 0.34, 1.23, 0.50, 0.90, 0.30 and 0.41 μkat/ml, respectively (p < 0.01). Aspartate transaminase (except for EEP-0.5 and EEP-1 groups) and alkaline phosphatase in the control group were significantly higher than those of positive control, vitamin-C and EEP-3 groups. Malondialdehyde level in plasma, liver and muscle tissues of control group were found significantly (p < 0.05) higher than those of positive control and EEP-3 groups. Catalase activities of blood, liver, kidney and heart were the highest in the control group. Reduced glutathione activities of plasma and liver of all groups were not significantly different from each other, whereas those of muscle, kidney and heart were significantly higher in the control group. Significantly lower levels of glutathione peroxidase were found in blood, liver and kidney tissues of the control group (p < 0.05), whereas those of muscle and heart were similar in all groups. The results of the present study suggest that EEP and specially EEP at the supplemented dose of 3 mg/kg diet might be considered to prevent oxidative stress in the broilers exposed to heat stress.

show abstract

Section: Discussionmentioning

confidence: 60%

Effects of Propolis on Selected Blood Indicators and Antioxidant Enzyme Activities in Broilers under Heat Stress

et al. 2009

View full text Add to dashboard Cite

show abstract

“…This result is in agreement with studies showing that artificially supplementing the diet of thermally stressed animals with various antioxidants improves their oxidative balance (Sahin et al, 2003;Sahin et al, 2006;Ates et al, 2006;Cao et al, 2011;Sahin et al, 2012a;Sahin et al, 2012b;Sahin et al, 2013). However, a fundamental difference between these studies and ours is that from our study it appears that animals can actively supplement their diet with antioxidants when exposed to temperatures outside their thermoneutral zone.…”

Section: Research Articlesupporting

confidence: 39%

“…If animals are not able to mount concomitantly an appropriate antioxidant defense system, being exposed to such temperatures results in increased oxidative damage (Al-Azraqi, 2008;Costantini et al, 2012). Interestingly, temperatureinduced oxidative damage can be reduced by supplementing the diet of animals with diverse antioxidants (Sahin et al, 2003;Sahin et al, 2006;Ates et al, 2006;Cao et al, 2011;Sahin et al, 2012a;Sahin et al, 2012b;Sahin et al, 2013). However, whether animals are able to actively supplement their diet with antioxidants to alleviate temperature-induced oxidative stress remains entirely unknown.…”

Section: Introductionmentioning

confidence: 99%

Self-supplementation and effects of dietary antioxidants during acute thermal stress

Beaulieu

Haas

Schaefer

2013

Journal of Experimental Biology

View full text Add to dashboard Cite

Thermal stress leads to increased production of reactive oxygen species. If an organism is not able to simultaneously mount an efficient antioxidant defense system, this may lead to increased oxidative damage, which is potentially deleterious in terms of health and fitness. Exposure to cold or heat is therefore expected to be associated with a high demand for antioxidants. In agreement, several studies have shown that supplementing the diet of thermally stressed organisms with antioxidants leads to a reduction of oxidative damage. However, whether organisms can actively supplement their diet with antioxidants to alleviate temperature-induced oxidative damage is unknown. Here, we show that captive Gouldian finches (Erythrura gouldiae) supplement their diet more with seeds rich in antioxidants below than within their thermoneutral zone. Moreover, having access to seeds rich in antioxidants at temperatures below thermoneutrality decreases their oxidative damage. These results indicate that, when facing a thermal challenge, animals are able to take advantage of the antioxidant properties of their food to improve their oxidative balance. Having access to food resources rich in antioxidants may therefore be of primary importance for organisms in their natural habitat, as it may help them to cope with oxidative constraints due to challenging temperature regimes.

show abstract

“…It exhibits antioxidant activity and effectively protects nuclear DNA, membrane lipids and cytosolic proteins against oxidative damage [13]. In this study, we investigated the effects of CAPE in STZ-induced diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

“…Caffeic acid phenethyl ester (CAPE), an active component of propolis, is one of these. The effects of CAPE (antimicrobial, anti-inflammatory, immunomodulatory, antimutagenic and antioxidant) have been revealed in several studies [13][14][15][16][17]. For this reason, we used CAPE in the current study.…”

Section: Introductionmentioning

confidence: 99%

Effects of caffeic acid phenethyl ester on oxidative stress, hystopathology and some biochemical parameters in streptozotocin-induced diabetic rats

Öztürk¹,

Aytekin²,

Özsoy³

et al. 2015

Turk J Bioch

View full text Add to dashboard Cite

Effects of caffeic acid phenethyl ester on oxidative stress, hystopathology and some biochemical parameters in streptozotocin-induced diabetic rats [Streptozotocin ile indüklenen diyabetik sıçanlarda oksidatif stres, histopatolojik ve bazı biyokimyasal parametrelere caffeic acid phenethyl esterin etkileri] ABSTRACT Objective: Diabetes mellitus (DM) is a significant health problem and its treatmet has taken herbal and syntetic remedies as well as insulin therapy. The aim of this study was to evaluate the therapeutic effects of caffeic acid phenil ester (CAPE) in rats with streptozotocin (STZ)-induced diabetes using hystopathological and biochemical methods. Methods: 22 adult Wistar Albino strain male rats were divided into three groups: control group (n=8), diabetic group (n=6) and the diabetic+CAPE group (n=8). Two groups were injected intraperitoneally (i.p.) with 50 mg/kg STZ to induce DM. Rats with blood glucose levels of 270 mg/dL or greater and with siagns of polyuria and polydipsia after 3 days were considered to be diabetic. Diabetic+CAPE group was given ip CAPE (10 µmol/kg/during 60 days) for treatment. Results: Liver malondialdehyde (MDA) level was significantly higher in the diabetic group. The higher liver MDA was supported by higher enzyme levels, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). MDA levels in kidney were not significantly different between groups and superoxide dismutase (SOD) levels were increased in CAPE group. Additionally, blood urea nitrogen (BUN) and creatinine enzyme levels were mostly stable in serum samples. At the end of the experiment, pancreatic tissue MDA in the experimental groups decreased compared with the control group. The kidney, liver and pancreas had almost normal histological structure in the CAPE group when compared to the diabetic group. Considering blood glucose levels, CAPE treatment maintained blood glucose at the same level with controls, compared to diabetic group. Conclusion: Liver tissue might be the most affected by oxidative stress caused DM. A single injection of STZ decreased the level of MDA in pancreatic tissue at the end of experiment. This decrease might be exhausting MDA due to disruption in tissue integrity. Consequently, it was observed that CAPE suppressed oxidative stress and decreased glucose levels in STZ-induced diabetic rats. Thus, it may be useful to use as remedies, the antioxidant properties, in addition to anti-diabetic drugs in DM. Key Words: CAPE, Diabetes Mellitus, Hyperglysemia, Oxidative stress, Streptozotocin Conflict of Interest: The authors have no conflict of interest. ÖZETAmaç: Diabetes mellitus (DM) önemli bir halk sağlığı problemidir ve tedavisinde insulin terapisinin yanısıra bitkisel ve sentetik ilaçlar verilmektedir. Bu çalışmanın amacı, streptozotocin (STZ) ile indüklenen diyabetli sıçanlarda histopatolojik ve biyokimyasal metotlar kullanılarak CAPE'nin tedavi edici etkilerini değerlendirmektir. Metod: 22 yetişkin erkek Wistar Albino ırkı sıçan 3 gruba ayrıldı: kontrol grubu (n=8), diyabetik grup ...

show abstract

Protective role of caffeic acid phenethyl ester in the liver of rats exposed to cold stress

Cited by 43 publications

References 19 publications

Effects of Propolis on Selected Blood Indicators and Antioxidant Enzyme Activities in Broilers under Heat Stress

Effects of Propolis on Selected Blood Indicators and Antioxidant Enzyme Activities in Broilers under Heat Stress

Self-supplementation and effects of dietary antioxidants during acute thermal stress

Effects of caffeic acid phenethyl ester on oxidative stress, hystopathology and some biochemical parameters in streptozotocin-induced diabetic rats

Contact Info

Product

Resources

About