Protective role of Cadherin 13 in interneuron development

Killen, Abigail C.; Barber, Melissa; Paulin, Joshua J. W.; Ranscht, Barbara; Parnavelas, John G.; Andrews, William

doi:10.1007/s00429-017-1418-y

Cited by 16 publications

(12 citation statements)

References 57 publications

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“…Chemotaxis assays were performed using a 48-well Boyden’s chamber (NeuroProbe) as described previously (Killen et al 2017 ). Briefly, 27 µl of DM containing 10% FBS were placed into the lower compartment of the chamber.…”

Section: Methodsmentioning

confidence: 99%

Cadherin 8 regulates proliferation of cortical interneuron progenitors

et al. 2018

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Cortical interneurons are born in the ventral forebrain and migrate tangentially in two streams at the levels of the intermediate zone (IZ) and the pre-plate/marginal zone to the developing cortex where they switch to radial migration before settling in their final positions in the cortical plate. In a previous attempt to identify the molecules that regulate stream specification, we performed transcriptomic analysis of GFP-labelled interneurons taken from the two migratory streams during corticogenesis. A number of cadherins were found to be expressed differentially, with Cadherin-8 (Cdh8) selectively present in the IZ stream. We verified this expression pattern at the mRNA and protein levels on tissue sections and found approximately half of the interneurons of the IZ expressed Cdh8. Furthermore, this cadherin was also detected in the germinal zones of the subpallium, suggesting that it might be involved not only in the migration of interneurons but also in their generation. Quantitative analysis of cortical interneurons in animals lacking the cadherin at E18.5 revealed a significant increase in their numbers. Subsequent functional in vitro experiments showed that blocking Cdh8 function led to increased cell proliferation, with the opposite results observed with over-expression, supporting its role in interneuron generation.

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Section: Methodsmentioning

confidence: 99%

Cadherin 8 regulates proliferation of cortical interneuron progenitors

et al. 2018

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“…This increase in inhibitory synaptic contacts could underlie the increase in gamma oscillations observed in ADHD patients discussed before 59 – 62 . Cdh13 KO mice show a reduced number of interneurons at embryonic day 18.5 233 but not at P21 133 . Experiments are needed to test whether the changes in interneuron number have a role in the aetiology of ADHD.…”

Section: Changes To Synapses Formed By Pv Interneuronsmentioning

confidence: 96%

Inhibitory control of the excitatory/inhibitory balance in psychiatric disorders

2018

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Neuronal networks consist of different types of neurons that all play their own role in order to maintain proper network function. The two main types of neurons segregate in excitatory and inhibitory neurons, which together regulate the flow of information through the network. It has been proposed that changes in the relative strength in these two opposing forces underlie the symptoms observed in psychiatric disorders, including autism and schizophrenia. Here, we review the role of alterations to the function of the inhibitory system as a cause of psychiatric disorders. First, we explore both patient and post-mortem evidence of inhibitory deficiency. We then discuss the function of different interneuron subtypes in the network and focus on the central role of a specific class of inhibitory neurons, parvalbumin-positive interneurons. Finally, we discuss genes known to be affected in different disorders and the effects that mutations in these genes have on the inhibitory system in cortex and hippocampus. We conclude that alterations to the inhibitory system are consistently identified in animal models of psychiatric disorders and, more specifically, that mutations affecting the function of parvalbumin-positive interneurons seem to play a central role in the symptoms observed in these disorders.

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“…The cadherin molecules with special regional expression at E14 and E18 indicate that they may play roles in avian hippocampal development, and the layer specificity of these molecules suggests they may be integral to neurogenesis specifically [11,[55][56][57]. The layer specificity of cadherin expression was also be observed in the lateral entorhinal cortex of the mouse [44,45,58,59]. In wild-type adult mice and the corresponding E18 chicken embryo APH subregions (dentate gyrus in mouse and V-shaped region in chicken), many cadherin molecules, such as Cdh2, Cdh4, Cdh6, Cdh7, Cdh11, Pchd1, Pcdh7, Pcdh9 and Pcdh10, showed similar regional expression.…”

Section: Possibility Of Cadherins Involved In Aph Evolutionmentioning

confidence: 88%

“…The expression of cadherins in chicken embryos has been mapped and reported by different groups [30,39,[41][42][43]. In the chicken embryonic brain, the expression and regulation of cadherins was studied during development [44][45][46]. However, except for a few molecules, the profile of cadherins in APH has not been systemically described.…”

Section: Regional Expression Of Cadherin Mrnas In Subdivisions Of Thementioning

confidence: 99%

Distribution of Cadherin in the Parahippocampal Area of Developing Domestic Chicken Embryos

Wang

Lin

et al. 2020

Exp Neurobiol

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Hippocampal formation is important in spatial learning and memory [1]. However, the molecular and cytoarchitecture bases are still not clear in evolution, and the homology between avian and mammalian species needs to be clarified [2, 3]. Avian hippocampal formation includes the hippocampus and the parahippocampal area (APH). This formation occurs in the medial and dorsomedial pallium and extends laterally to part of the caudolateral pallium. The avian APH does not have clear boundaries with the hippocampus. Hippocampal formation was divided into the hippocampus and APH first [2, 4]. Later, hippocampal formation was divided into seven subdivisions in other studies based on the different immunoactivities of neural peptides antibodies [5, 6]. Some researchers subsequently divided hippocampal formation into five subdivisions: dorsomedial (DM) [7], dorsolateral (DL), ventral core, ventrolateral area of the V-shaped layer and ventromedial area of the V-shaped layer [8, 9]. Recently, the APH has been considered to correspond to the DM and DL subdivisions (Fig. 1A) [10]. The APH has also been divided into four portions, the medial APH (APHm), the intermediate APH (APHi), the lateral APH (APHl) and the caudolateral APH (APHcl), in chicken embryos (Fig. 1B) [11]. A small portion of the superficial corticoid dorsolateral area is also included in the caudolateral APH part [12]. The APH is a structure that develops at a later stage during the embryonic period in avian species. This long and thin

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Protective role of Cadherin 13 in interneuron development

Cited by 16 publications

References 57 publications

Cadherin 8 regulates proliferation of cortical interneuron progenitors

Cadherin 8 regulates proliferation of cortical interneuron progenitors

Inhibitory control of the excitatory/inhibitory balance in psychiatric disorders

Distribution of Cadherin in the Parahippocampal Area of Developing Domestic Chicken Embryos

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