Protective role of apple cider vinegar (APCV) in CCl4-induced renal damage in wistar rats

Abstract

Background Apple Cider Vinegar, (APCV) has been locally associated with a number of health benefits, including protection against oxidative stress and related ailments. It is on this background the present study assessed its protective effects against carbon tetrachloride (CCl 4 )-induced oxidative damage in kidneys of rats. Methods Twenty four adult rats of Wistar strain were randomly assigned to four groups (n = 6). While group I animals served as control; kidney oxidative damage was induced in groups II and III animals using a single intraperitoneal injection of CCl 4 (100%, 1.73 mL/kg body weight, BW). Group II animals were left untreated and groups III and IV counterparts were administered APCV (1.56 mL/kg BW) once daily for a period of 7 days. Thereafter, the animals were fasted over night, and sacrificed by cervical dislocation, and samples (blood and kidney tissues) were collected for biochemical/histopathological examinations. Kidney function markers including urea, creatinine, sodium ion (Na + ) and potassium ion (k + ) were determined in the serum while thin sections of kidneys were processed for histopathological screening. Results Compared to the control animals, CCl 4 administration caused kidney damage as evidenced by significant (P < 0.05) increase in the evaluated indices (urea, creatinine, Na + and K + ). Interestingly, treatment of CCl 4 -exposed rats with APCV markedly reversed the above alterations to near normal. Besides, APCV treatment ameliorated the histological derangements (hemorrhagic lesions) caused by CCl 4 in the kidney of the experimental rats. Conclusion These observations apparently suggest that Apple cider vinegar has the therapeutic potential to protect against renal impairment and attendant malfunction.

Efficacy of Olive Oil In Amelioration of Nephrotoxicity In Experimental Male Rats

“…From the biochemical background, the elevated creatinine level is ascribed to deficient glomerular filtration due to loss in glomeruli function. Also, the significant rise in the urea and uric acid Clwere at the normal level, and these results disagreed with [33,34] who reported an elevated level of both Na + and K + in CCL 4 induced renal injury in the experimental rat model. Incidence of NEP by CCL 4 leads to a higher level of both TBARS and NO in the renal tissue, and that was linked to the acidic media of CCL 4 that destruct the renal vascular endothelium and enhance the process of lipid peroxidation and biosynthesis of NO with huge amount [35].…”

Comparative Nephroprotective Effect of Telfaria occidentalis Leaf Extracts

“…Creatinine is the byproduct of creatine phosphate in muscles, and it is produced at a constant rate by the body. For the most part, creatinine is cleared from the blood entirely by the kidney [23]. Decreased clearance by the kidney results in increased blood creatinine.…”

Nowe doniesienia na temat właściwości prozdrowotnych octu jabłkowego

“…Natomiast, gdy zwierzętom narażonym na oddziaływanie tetrachlorometanu podawano do spożycia ocet jabłkowy, wtedy nie obserwowano uszkodzenia nerek, a wskaźniki uszkodzenia bariery filtracyjnej nerek przyjmowały wartości charakterystyczne dla poziomu fizjologicznego normalnego. Poza tym zauważono, że podawanie do spożycia octu jabłkowego zwierzętom narażonym na tetrachlorometan łagodzi konsekwencje histologiczne przejawiające się zahamowaniem lub ograniczeniem zmian krwotocznych spowodowanych kontaktem tkanek z ksenobiotykami (CCl 4 w nerkach szczurów) (Asejeje i in., 2020).…”