Protective Role for Antioxidants in Acute Kidney Disease

Dennis, Joanne M.; Witting, Paul K.

doi:10.3390/nu9070718

Cited by 203 publications

(120 citation statements)

References 152 publications

(258 reference statements)

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“…La vitamina C tiene efectos inmunoestimulantes, propiedades antioxidantes, antiinflamatorias, antivirales y posibles efectos antimutagénicos 3,4 . Se ha demostrado que la vitamina C mejora la quimiotaxis de neutrófilos, la fagocitosis y, por lo tanto, el aclaramiento microbiano 5,6 . Además, promueve la proliferación de células T y células natural killer que modulan sus funciones 7 .…”

Section: Efectos Biológicosunclassified

Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID-19

Hernández

Papadakos

Torres

et al. 2020

Revista Española de Anestesiología y Reanimación

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publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.Cómo citar este artículo: Hernández A, et al. Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID PALABRAS CLAVE COVID-19; SARS-CoV-2; Vitamina C; OzonoResumen La neumonía causada por coronavirus, que se originó en Wuhan, China, a finales de 2019, se ha extendido por todo el mundo convirtiéndose en una pandemia. Desafortunadamente, a día de hoy no existe ninguna vacuna específica para el virus COVID-19, y el tratamiento está siendo de soporte con añadido de antivirales y otros fármacos, sin que hasta la fecha se haya evidenciado un beneficio claro. Muchos de estos pacientes se deterioran rápidamente y requieren ser intubados y ventilados mecánicamente, lo que está provocando el colapso del sistema sanitario en muchos países debido a la falta de ventiladores y de camas de críticos.En este documento revisamos dos terapias adyuvantes sencillas de aplicar, sin efectos deletéreos y de un coste bajo que podrían ser de utilidad para el tratamiento de la infección por coronavirus agudo severo asociado al síndrome respiratorio agudo (SARS-CoV-2). La vitamina C, un potente antioxidante, se ha convertido en una terapia relevante debido a sus beneficios potenciales cuando se administra por vía intravenosa. El efecto potencial de la vitamina C en la reducción de la inflamación en los pulmones podría desempeñar un papel clave en la lesión pulmonar causada por la infección por coronavirus. Otra posible terapia eficaz es el ozono. Pese a la controversia que siempre le ha acompañado, se ha estudiado y utilizado ampliamente durante muchos años y su eficacia se ha demostrado en múltiples estudios. Sin embargo, nuestro objetivo no es hacer una revisión exhaustiva de dichas terapias sino difundir sus efectos beneficiosos. * Autor para correspondencia. Correo electrónico: albimar23@yahoo.es (A. Hernández). Cómo citar este artículo: Hernández A, et al. Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID

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Section: Efectos Biológicosunclassified

Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID-19

Hernández

Papadakos

Torres

et al. 2020

Revista Española de Anestesiología y Reanimación

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“…Among vitamin C’s pleiotropic functions that are of relevance to critical illness are its immune-enhancing effects, anti-oxidant properties, and potential anti-mutagenic effects[ 11 , 12 ]. Vitamin C has been shown to enhance neutrophil chemotaxis, phagocytosis, and thus microbial clearance[ 13 , 14 ].…”

Section: Biological Effects Of Vitamin Cmentioning

confidence: 99%

Vitamin C in the critically ill - indications and controversies

Nabzdyk

Bittner

2018

WJCCM

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Ascorbic acid (vitamin C) elicits pleiotropic effects in the body. Among its functions, it serves as a potent anti-oxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that high-dose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential.

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“…Endothelial cell Capn4 deficiency reduced renal NO and ROS production in endotoxemic mice by inhibiting iNOS expression NO and ROS are involved in the pathological process of renal injury 23 . Our previous research showed that inhibiting calpain by overexpressing calpastatin decreased NO production in a model of diabetes 11 .…”

Section: Calpain Activation Was Involved In Lps-induced Pmec Apoptosismentioning

confidence: 97%

Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production

Liu

Zheng

et al. 2020

Exp Mol Med

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To explore the role of calpain and its signaling pathway in lipopolysaccharide (LPS)-induced acute kidney injury (AKI), animal models of endotoxemia were established by administration of LPS to mice with endothelial-specific Capn4 knockout (TEK/Capn4 −/− ), mice with calpastatin (an endogenous calpain inhibitor) overexpression (Tg-CAST) and mice with myeloid-specific Capn4 knockout (LYZ/Capn4 −/− ). Mouse pulmonary microvascular endothelial cells (PMECs) were used as a model of the microvascular endothelium and were stimulated with LPS. Renal function, renal inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) expression, cellular apoptosis, plasma and renal levels of NO and reactive oxygen species (ROS), and phosphorylation of mitogenactivated protein kinase (MAPK) family members (p38, ERK1/2, and JNK1/2) were examined. Moreover, a calpain inhibitor, calpastatin overexpression adenoviruses and MAPK inhibitors were used. Significant renal dysfunction was induced by LPS stimulation, and recovery was observed in TEK/Capn4 −/− and Tg-CAST mice but not in LYZ/ Capn4 −/− mice. Endothelial Capn4 knockout also abrogated the LPS-induced increases in renal iNOS expression, caspase-3 activity and apoptosis and plasma and renal NO and ROS levels but did not obviously affect renal eNOS expression. Moreover, LPS increased both calpain and caspase-3 activity, and only the expression of iNOS in PMECs was accompanied by increased phosphorylation of p38 and JNK. Inhibiting calpain activity or p38 phosphorylation alleviated the increased iNOS expression, NO/ROS production, and cellular apoptosis induced by LPS. These results suggest that endothelial calpain plays a protective role in LPS-induced AKI by inhibiting p38 phosphorylation, thus attenuating iNOS expression and further decreasing NO and ROS overproduction-induced endothelial apoptosis.

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Protective Role for Antioxidants in Acute Kidney Disease

Cited by 203 publications

References 152 publications

Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID-19

Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID-19

Vitamin C in the critically ill - indications and controversies

Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production

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