Protective Responce of Methnolic Extract of Garcinia Indica Fruits on CCl4 Induced Liver Damage

P, Swathi; Kumar, Tekeshwar; Babu, M. M.; Vijay, Ch.

doi:10.1016/s0975-3575(10)80009-4

Cited by 1 publication

(1 citation statement)

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“…But, when Livplus was given along with CCl 4, there was a significant increase in total protein which may be due to the hepatoprotective effect. 22 In previous study, it was also reported that Gamma GT (Gamma-Glutamyl Transpeptidase) was significantly increased in rat intoxicated with CCl 4 in comparison with normal control group. 23 GGT which is present in the membrane of endoplasmic reticulum of the hepatocytes.…”

Section: -21mentioning

confidence: 87%

Hepatoprotective effect of Livplus-A polyherbal formulation

Maheshwari¹,

Pandya²,

Balaraman³

et al. 2015

Phcog J

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Objective: The aim of the present study was to investigate the hepatoprotective effect of Livplus (a polyherbal formulation) against CCl 4 -induced hepatotoxicity in rats. Methods: Hepatotoxicity was induced in rats by i.p. injection of CCl 4 once three days for 14 days. Livplus or Silymarin was administered along with CCl 4 and the biochemical parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkalinephosphatase (ALP), total bilirubin (TB), direct bilirubin, total protein (TP), gamma-glutamyl transferase (GGT), total cholesterol (TC) and triglycerides (TG) were estimated. Furthermore, biomarkers of oxidative stress such as MDA levels, Glutathione contents, SOD and catalase activity in liver tissue were estimated. Results: Treatment with Livplus significantly reduced the elevated levels of ALT, AST, ALP, bilirubin (direct and total), GGT, TC, TG and increased levels of TP compared to CCl 4 control rats. The treatment with Livplus also showed a significant increase in glutathione contents, SOD and catalase activity and a decrease in MDA levels compared to CCl 4 control rats. Conclusion: The finding of present study indicates that Livplus showed a potential hepatoprotective activity. These results support the traditional use of Livplus in the treatment of liver disorders.

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Section: -21mentioning

confidence: 87%