Protective properties of five newly synthesized cyclic compounds against sodium azide and N-methyl-N′-nitro-N-nitrosoguanidine genotoxicity

Turhan, Kadir; Öztürkcan, S. Arda; Turgut, Zühal; Karadayı, Mehmet; Güllüce, Medine

doi:10.1177/0748233711416954

Cited by 12 publications

(11 citation statements)

References 49 publications

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“…Because of their importance in biological systems, iminothiazolidinone derivatives have a widerange usage potential in drug development studies for human healthcare applications (Babaoglu et al, 2003; Bonde and Gaikwad, 2004; Kline et al 2008; Rahman et al, 2005). On the other hand, this situation requires determination of toxicological properties of these compounds on human, animals, plant species, other types of organisms, and the environment before more complicated biological activity studies are performed (Turhan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic evaluation of newly synthesized iminothiazolidinones

et al. 2017

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The current study was designed to assess the potential toxicological effects of newly synthesized iminothiazolidinones by employing Ames Salmonella, Escherichia coli WP2, Zea mays seed germination, and random amplified polymorphic DNA (RAPD) assay systems. The bacterial tester strains S. typhimurium TA1535, TA1537, TA1538, TA98, TA100, and E. coli WP2 uvrA were chosen to test the direct gene mutation inducing capabilities of the test materials in prokaryotic systems and Z. mays seeds for determination of potential toxicological effects in eukaryotic systems. OPA-3 and OPA-6 primers were used in the RAPD analysis to determine genotoxic activities on the eukaryotic genomes. According to the results, none of the test materials showed significant mutagenic activity on the bacterial tester strains at the chosen concentrations. Additionally, none of the tested compounds showed inhibition of the germination of Z. mays seeds. In contrast, the RAPD analysis results were inconsistent with the bacterial reversion assays and the seed germination assay results. All test materials significantly changed the RAPD profiles for OPA-3; however, only compound 5 showed a significant change for OPA-6 when compared with the control groups. In conclusion, the newly synthesized iminothiazolidinone derivatives (C1-C5) were determined as potentially genotoxic compounds and they should be checked with multiple toxicology test systems before further studies to determine their actual use.

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Section: Introductionmentioning

confidence: 99%

Genotoxic evaluation of newly synthesized iminothiazolidinones

et al. 2017

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“…Recently, the antimutagenic potential of some newly synthesized nitrogen- and oxygen-containing heterocyclic compounds against NaN 3 and MNNG was demonstrated using the Ames/ Salmonella and Escherichia coli WP2 bacterial reverse mutation assay systems (Turhan et al 2012). The antimutagenic activity of the tested compounds was probably due to the inhibition of L-azidoalanine and O6-methylguanine formation.…”

Section: Antimutagens That Inhibit the Activation Of Mutagensmentioning

confidence: 99%

Antimutagenic compounds and their possible mechanisms of action

et al. 2014

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Mutagenicity refers to the induction of permanent changes in the DNA sequence of an organism, which may result in a heritable change in the characteristics of living systems. Antimutagenic agents are able to counteract the effects of mutagens. This group of agents includes both natural and synthetic compounds. Based on their mechanism of action among antimutagens, several classes of compounds may be distinguished. These are compounds with antioxidant activity; compounds that inhibit the activation of mutagens; blocking agents; as well as compounds characterized with several modes of action. It was reported previously that several antitumor compounds act through the antimutagenic mechanism. Hence, searching for antimutagenic compounds represents a rapidly expanding field of cancer research. It may be observed that, in recent years, many publications were focused on the screening of both natural and synthetic compounds for their beneficial muta/antimutagenicity profile. Thus, the present review attempts to give a brief outline on substances presenting antimutagenic potency and their possible mechanism of action. Additionally, in the present paper, a screening strategy for mutagenicity testing was presented and the characteristics of the most widely used antimutagenicity assays were described.

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“…They were reported to work through possible inhibition of L-azidoalanine and O 6 -methylguanine formation [34]. Similarly, Terminalia arjuna constituents were reported to suppress the mutagenic effect of the aromatic amine, i.e., 2-aminofluorene (2-AF) by inhibiting its metabolic activation [35].…”

Section: Inhibition Of Promutagen Bioactivationmentioning

confidence: 99%

Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

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Mutation is the process leading to heritable changes in the genetic material of an organism and caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA replication, repair, and recombination. Agents contributing to the mutagenic burden in the environment could be from industrial sources, wide spectrum applications of biocides in the agriculture, and other contaminants. As many of these mutagenic chemicals can induce severe disorders in humans including cancer and a large spectrum of inherited diseases, it is important to detect such mutagenic agents precisely and rapidly, and also look for an approach to combat them. Natural occurring dietary antimutagens primarily from health protective foods such as fruits and vegetables could provide a mechanism to counteract the deleterious effect of these mutagens. The World Health Organization (WHO) indicates that one-third of all cancer deaths are preventable and that diet is closely linked to cancer prevention. These health protective phytochemicals particularly antimutagenic ones could provide an effective solution to these concerns. The current review deals with understanding of the mutagenic events, methods of its analysis and a brief compilation of the existing scientific findings related to the dietary sources having potential to counteract the effects of the mutagenic exposures from different sources. The review would provide an opportunity to look into the science, think about the possible future perspectives and mechanism to translate the outcome of the scientific research for benefits of the mankind.

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Protective properties of five newly synthesized cyclic compounds against sodium azide and N-methyl-N′-nitro-N-nitrosoguanidine genotoxicity

Cited by 12 publications

References 49 publications

Genotoxic evaluation of newly synthesized iminothiazolidinones

Genotoxic evaluation of newly synthesized iminothiazolidinones

Antimutagenic compounds and their possible mechanisms of action

Fruits and Vegetables as Dietary Sources of Antimutagens

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