Protective potential of Black grapes against lead induced oxidative stress in rats

Lakshmi, B. V. S.; Sudhakar, M.; Aparna, M

doi:10.1016/j.etap.2013.01.008

Cited by 69 publications

(46 citation statements)

References 33 publications

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“…The total protein level, including albumin level, will be depressed in hepatotoxic conditions due to defective protein biosynthesis in liver [46]. The hypoproteinemia and hypoalbuminemia in the present work is in agreement with results obtained by other researchers [33],who reported hypoproteinemia and hypoalbuminemia in rats received lead nitrate (5 mg/Kg bw) intraperitoneal daily for 30 days. Similarly, others [47], found a decrease in rat's hepatic total protein content in response to lead intoxication.…”

Section: Discussionsupporting

confidence: 95%

“…In the present study, the antioxidant system, reduced glutathione, total antioxidant and superoxide dismutase activities were significantly decreased in the serum of lead exposed rats while there was an increase in malnoaldihyide in accordance with previous studies [33][34][35].Additionally, others have concluded a high correlation between decreased superoxide dismutase and decreased copper concentrations in the blood of animals [36]. Lead induced copper deficiency has been recorded by Adler and colleagues [37], where the authors indicated that this effect of lead decreased scavenging of ROS resulted in oxidative damage [38].…”

Section: Discussionsupporting

confidence: 94%

“…Likewise, the liver markers (ALT, AST, and ALP) as well as renal markers (urea, creatnine and uric acid) were not significantly changed in ZO treated group. The ZO extracts are harmless on the liver and other tissues [33]. SOD, GSH, GPx and TAC are the major antioxidants involved in the defense mechanism against lipid peroxidation in biological systems; they convert active oxygen molecules into non-toxic compounds.…”

Section: Discussionmentioning

confidence: 99%

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Immunomodulatory and Antioxidant Protective Effect of Zingiber officinale, in Lead Intoxicated Rat

Boshy¹

2015

Prensa Med Argent

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Background and Aim: Zingiber officinale (ZO) is commonly used as one of natural food additives. This study was designed to evaluate immunomodulatory and antioxidant effect of Zingiber officinale extract (ZO) against lead toxicity in rats. Material and Methods:Forty eight male albino rats were divided into 6 equal groups and treated daily for 21 days. Group I; normal control, Group II treated with lead acetate in drinking water at a dose of 1000 ppm. Groups III and IV received 1000 ppm of lead and administrated orally ZO ethanol extract at 200 and 400 mg/kg bw doses, respectively. Groups V and VI, were administrated orally ZO extract at doses 200 and 400 mg /kg bw daily, respectively. At the end of the treatment period, blood samples were collected from all groups to assess some selective humoral immunological and biochemical parameters. Results:In the lead exposed group, Tumor necrosis factor-α (TNF α), Interleukin-1β (IL-1 β), Interleukin 6 (IL-6), Interleukin 10 (IL-10) and malnodiladhyide (MDA) were significantly increased compared with the control group, while gamma interferon (IFN-γ), glutathione (GSH), superoxide dismutase (SOD), total antioxidant (TAC),were decreased. Regarding, liver and renal markers, in lead treatment group, there were significantly increased in the activities of amino transferases (ALT, AST) urea; creatinine and phosphorous, while total plasma proteins, albumin and calcium were significantly decreased. The ZO extract alone at the two tested doses did not induce any significant changes in hepatorenal markers, while the antioxidant markers were significant increase. ZO extract in combination with cadmium significantly reduced the elevation of serum IL-1, IL-6, TNF, IL-10 and MDA, in addition to augmenting the antioxidant enzyme activities. Moreover, ZO ameliorate lead induced hepatorenal damage. Conclusion:It could be concluded that the ZO extract has a potential immunomodulatory, antioxidant activity and a protective effect against lead toxicity.

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Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Immunomodulatory and Antioxidant Protective Effect of Zingiber officinale, in Lead Intoxicated Rat

Boshy¹

2015

Prensa Med Argent

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“…The treatment with bromelain did cause a significant reduction of Pb accumulation in the kidney and spleen, however, in the liver there was no detectable change observed due to bromelain treatment. The levels of serum MDA, a biomarker of metal-induced lipid peroxidation, were significantly increased in the groups exposed to both low and high doses of Pb in comparison to the control group which are consistent with the earlier studies [15,16]. Bromelain effectively reduced the MDA levels in the group exposed to a lower dose of lead.…”

Section: Discussionsupporting

confidence: 80%

“…These enzymes are usually elevated in acute hepatotoxicity or mild hepato-cellular injury, but also tend to decrease with prolonged intoxication due to liver damage [9]. In consensus with previous studies [15,21], in the present study the serum ALT levels were increased by Pb exposure in a dose dependent manner in comparison to the control. And at both levels of lead exposure (30 mg/kg and 60 mg/kg) the bromelain significantly reduced the serum ALT levels.…”

Section: Discussionsupporting

confidence: 80%

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Al-Otaibi¹,

Virk²,

Elobeid³

2015

Acta Biologica Hungarica

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The present study investigates the protective efficacy of stem bromelain against lead-induced toxicity in male Wistar rats. There were six experimental groups; Group I was negative control, Group II was administered only 20 mg/kg of stem bromelain. Group III and V were orally exposed to 30 mg/kg/day and 60 mg/kg/day of lead acetate, respectively. Group IV and Group VI were exposed to both low and high dose of lead acetate, respectively, and treated with 20 mg/kg stem bromelain. The experimental period was 21 days. The end points evaluated were, lead accumulation in kidney, liver and spleen, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, serum malonaldehyde (MDA) cholesterol and triglycerides levels. Co-administration of stem bromelain with lead markedly reduced the lead accumulation in the kidney and spleen. The treatment of stem bromelain also reduced the serum MDA levels in the group exposed to lower dose of lead and serum triglyceride level in the group exposed to higher dose of lead. The lead-induced modulated levels of serum ALT and AST were also alleviated by bromelain treatment. Our key findings suggest a chelating potential of stem bromelain for combating lead toxicity and oxidative stress. Bromelain represents a novel approach to the treatment of metal toxicity and metabolic disorders with a limited therapeutic window.

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Curcumin‐loaded cockle shell‐derived calcium carbonate nanoparticles ameliorates lead‐induced neurotoxicity in rats via attenuation of oxidative stress

Mailafiya

Abubakar

Chiroma

et al. 2022

Food Science & Nutrition

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A substantial global health burden is associated with neurotoxicity caused by lead (Pb) exposure and the common mechanism of this toxicity is mainly via oxidative damage. Curcumin has remarkable pharmacological activities but remains clinically constrained due to its poor bioavailability when orally administered. Currently, cockle shell‐derived calcium carbonate nanoparticle (CSCaCO 3 NP) is gaining more acceptance in nanomedicine as a nanocarrier to various therapeutics. This study aimed at investigating the ameliorative effect of curcumin‐loaded CSCaCO 3 NP (Cur‐CSCaCO 3 NP) on lead‐induced neurotoxicity in rats. A total of 36 male Sprague–Dawley rats were randomly assigned into five groups. Each group consists of 6 rats apart from the control group which consists of 12 rats. During the 4 weeks induction phase, all rats received a flat dose of 50 mg/kg of lead while the control group received normal saline. The treatment phase lasted for 4 weeks, and all rats received various doses of treatments as follows: group C (Cur 100) received 100 mg/kg of curcumin, group D (Cur‐CSCaCO 3 NP 50) received 50 mg/kg of Cur‐CSCaCO 3 NP, and group E (Cur‐CSCaCO 3 NP 100) received 100 mg/kg of Cur‐CSCaCO 3 NP. The motor function test was carried out using the horizontal bar method. The cerebral and cerebellar oxidative biomarker levels were estimated using ELISA and enzyme assay kits. Lead‐administered rats revealed a significant decrease in motor scores and SOD activities with a resultant increase in MDA levels. Furthermore, marked cellular death of the cerebral and cerebellar cortex was observed. Conversely, treatment with Cur‐CSCaCO 3 NP demonstrated enhanced ameliorative effects when compared with free curcumin treatment by significantly reversing the aforementioned alterations caused by lead. Thus, CSCaCO 3 NP enhanced the efficacy of curcumin by ameliorating the lead‐induced neurotoxicity via enhanced attenuation of oxidative stress.

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Protective potential of Black grapes against lead induced oxidative stress in rats

Cited by 69 publications

References 33 publications

Immunomodulatory and Antioxidant Protective Effect of Zingiber officinale, in Lead Intoxicated Rat

Immunomodulatory and Antioxidant Protective Effect of Zingiber officinale, in Lead Intoxicated Rat

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Curcumin‐loaded cockle shell‐derived calcium carbonate nanoparticles ameliorates lead‐induced neurotoxicity in rats via attenuation of oxidative stress

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