Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model

Liu, Xuefei; Zhang, Xinghua; Ye, Lin; Yuan, Haitao

doi:10.1016/j.biopha.2016.02.015

Cited by 66 publications

(60 citation statements)

References 36 publications

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“…In contrast to Th17 cells, Treg cells are generally functionally defective in patients with RA: Treg cells are enriched in joint synovial fluid of RA patients, working to suppress aberrant inflammatory responses and limit the effects of Th17 cells by reducing its accumulation at the site of inflammation . Our findings that berberine could attenuate the Th17 cell response were consistent with the recent reports that berberine treatment could suppress the Th17 response in dextran sodium sulfate‐ and TNBS‐induced colitis, type 1 diabetes, EAE, and experimental autoimmune myocarditis . Therefore, we came to the first conclusion that berberine was effective in alleviating ongoing severity of rat CIA, and that the underlying mechanisms involved the inhibition of the systemic Th17 cell response.…”

Section: Discussionsupporting

confidence: 90%

Berberine ameliorates collagen‐induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut

et al. 2017

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Berberine, an isoquinoline alkaloid, has been reported to ameliorate various autoimmune diseases including rheumatoid arthritis by oral administration. However, its mechanism remains mysterious due to an extremely low bioavailability. The fact that berberine readily accumulates in the gut, the largest endocrine organ in the body, attracted us to explore its anti-arthritic mechanism in view of the induction of intestinal immunosuppressive neuropeptides. In this study, berberine (200 mg·kg , i.g.) was shown to ameliorate collagen-induced arthritis in rats, which was manifested by the reduction of clinical signs and joint destruction, as well as marked down-regulation of Th17 cell frequency and interleukin-17 level in blood. In contrast, an intravenous injection of berberine failed to affect arthritis in rats, implying that its anti-arthritic effect was gut-dependent. Further studies revealed that oral berberine selectively elevated the levels of cortistatin, of five gut-derived neuropeptides tested, in the intestines and sera of arthrititic rats. Antagonists of ghrelin/growth hormone secretagogue receptor 1 (a subtype of cortistatin receptor) almost completely abolished the ameliorative effect of berberine on arthritis and Th17 cell responses in rats. In vitro, berberine showed a moderate ability to promote the expression of cortistatin in nerve cells, which was strengthened when the nerve cells were cocultured with enteroendocrine cells to induce an autocrine/paracrine environment. In summary, oral berberine exerted anti-arthritic effect through inhibiting the Th17 cell response, which was closely associated with the induction of cortistatin generation from gut through augmenting autocrine/paracrine action between enteric nerve cells and endocrine cells.

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Section: Discussionsupporting

confidence: 90%

Berberine ameliorates collagen‐induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut

et al. 2017

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“…In addition, the isoquinoline alkalkaloid berberine (161) has been associated with myocardial protective effects. [339][340][341] By differentially modulating the activities of p-STAT1, p-STAT3, and p-STAT4 and, thus, suppressing…”

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confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

116

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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“…[50] Berberine is an alkaloid derivative extracted from a variety of plants, and Liu X'experiment reveals its immunomodulatory effects in an autoimmune myocarditis rat model. [51] All these herbal products had a synergic antiinflammation effect.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of Qianlie Tongli decoction on chronic prostatitis/chronic pelvic pain syndrome induced by peptide T2 in mice

Cui

Naveed

Wang

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives This study was undertaken to reveal therapeutic effects and the preliminary mechanism of Chinese medicine formula Qianlie Tongli decoction (QTD) in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods A total of 50 male C57BL/6 mice were randomly divided into five groups. All groups except the control group were injected subcutaneously T2 peptide emulsion, which induced the CP/CPPS model. After the induction of CP/CPPS, the model group was given normal saline by oral gavage while low‐dose, medium‐dose and high‐dose groups were treated with Chinese medicine formula. Micturition habits and pain behaviour of mice were analysed for each group. Haematoxylin and eosin (H&E) staining was used to investigate prostate inflammation. The serum level of tumour necrosis factor‐α (TNF‐α) was measured by enzyme‐linked immunosorbent assay (ELISA) kit. Key findings Chinese medicine formula significantly reduced the number of urine spots and improved pain response frequency in the medium‐dose and high‐dose group. The high‐dose group showed reduced considerably inflammatory lesion and inflammatory cell infiltration than the low‐dose and medium‐dose groups. Serum levels of TNF‐α in the high‐dose group were significantly reduced compared with the model group. Conclusions The results demonstrated the therapeutic effects of Qianlie Tongli decoction in CP/CPPS mice by analysing clinically relevant symptoms (urinary tract system, pelvic pain and prostate inflammation) and preliminarily explored the inflammatory‐related treatment mechanisms by measuring TNF‐α.

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Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model

Cited by 66 publications

References 36 publications

Berberine ameliorates collagen‐induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut

Berberine ameliorates collagen‐induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut

Biologically active isoquinoline alkaloids covering 2014–2018

Therapeutic effects of Qianlie Tongli decoction on chronic prostatitis/chronic pelvic pain syndrome induced by peptide T2 in mice

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