“…Harbige et al also demonstrated that gamma linoleic acid (GLA) supplementation could reduce the severity of both acute EAE and the relapsing phases of chronic. Further analysis revealed an increase in production of transforming growth factor -1 and PGE 2 , both associated with a reduction in the inflammatory response in EAE models (Harbige et al, 1995;Harbige et al, 1997;Harbige et al, 2000).…”