Protective mechanism of turmeric (
            <i>Curcuma longa</i>
            ) on carbofuran-induced hematological and hepatic toxicities in a rat model

Hossen, Md. Sakib; Tanvir, E. M.; Prince, Maruf Billah; Paul, Sudip; Saha, Moumoni; Ali, Md. Yousuf; Gan, Siew Hua; Khalil, Md. Ibrahim; Karim, Nurul

doi:10.1080/13880209.2017.1345951

Cited by 41 publications

(53 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Groups 1 2 3 4 5 6 7 Leu. (10 3 /µL) 8.8±2.5 8.2±1.9 In the study by Hossen et al (2017), the MCV and HCM concentration levels increased when animals were fed for a period of 28 days with species Curcuma Longa. While the other hematological data remained unchanged.…”

Section: Parametermentioning

confidence: 86%

Evaluation of Curcuma zerumbet (Zingibaraceae) rhizome extracts sub-acute toxicity on Wistar rats

Castro¹,

Pinheiro²,

Marinho³

et al. 2018

Afr. J. Biotechnol.

View full text Add to dashboard Cite

Plant extracts have been lately used by the population to treat various types of diseases, and this has been notably encouraged by the World Health Organization (WHO). Curcuma zerumbet (Zingiberaceae) belonging to the family of the Zingiberaceae, is herbaceous, perennial and, utilized by the population to treat gastric disorders. However, data on the subacute toxicity of this species are scarce in the literature. Therefore, the present work aimed to ascertain the subacute toxicity of different doses of the aqueous and hydroalcoholic extracts from C. zerumbet. These extracts were orally administered through gavage in Wistar rats for 28 consecutive days. This study followed the instructions put forth by Guideline 407 (subacute toxicity) of Organization for Economic Cooperation and Development (OECD). In specific pharmacological tests for acute and subacute toxicity in rats, it can be stated that C. zerumbet extracts doses greater than 5 g/kg neither caused mortality nor presented oral toxicity. Therefore, the extracts toxicity parameters analyzed in different doses on the groups of animals have shown no significant difference from those found in the control group. This allows one to conclude C. zerumbet (Zingiberaceae) rhizome aqueous and alcoholic extracts in high doses to harbor very low toxicity within a short time.

show abstract

Section: Parametermentioning

confidence: 86%

Evaluation of Curcuma zerumbet (Zingibaraceae) rhizome extracts sub-acute toxicity on Wistar rats

Castro¹,

Pinheiro²,

Marinho³

et al. 2018

Afr. J. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Oral treatment with TTC led to a profound increase in the serum SGPT, SGOT, and ALP activities in animals that could be potentially attributed to liver damage and impaired biosynthesis of the enzymes. Altered permeability of cell membranes due to TTC toxicity likely allowed cellular enzymes to leak out from the cytosol of the hepatocyte into the systemic circulation, indicating the drug‐induced necrosis and inflammatory reactions (Hossen et al, ; Paul et al, ). These findings are consistent with the results of Shabana et al () and (Asha et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…However, co‐treatment with propolis extract significantly reduced the serum SGPT, SGOT, and ALP levels in rats in comparison with the TTC‐alone treatment group, demonstrating that the possible action of propolis in maintaining membrane integrity and thus restricting the leakage of these enzymes. The protective mechanism can be attributed to the phenolic compounds (including gallic acid, benzoic acid, salicylic acid, pyrogallol, and rutin), tannins, ascorbic acid, and vitamin E in this propolis extract all of which have inhibitory activities on membrane lipid peroxidation with robust antioxidant activities (Ahmed et al, ; Hossen et al, ; Paulino et al, ; Tanvir et al, ). Moreover, a significant rise in the TB level following TTC administration is one of the most important clinical indicators of the severity of necrosis and the TP levels in serum may also indicate the severity of hepatic injury (Afroz, Tanvir, Hossain, et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Altered lipid metabolism is another important indication of liver toxicity (Hossen et al, ). The increase in TG and cholesterol levels (TC and VLDL‐C) along with a decreased HDL‐C level in serum in TTC administered rats, suggesting the possible effects of TTC on membrane permeability of the hepatocytes and/or impaired expression of the genes involved in lipid metabolism (Yin et al, ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ameliorative effects of ethanolic constituents of Bangladeshi propolis against tetracycline‐induced hepatic and renal toxicity in rats

et al. 2019

Self Cite

View full text Add to dashboard Cite

The study reports the phenolic composition of propolis from Bangladesh and its ameliorative effects against tetracycline‐induced hepatonephrotoxicity in rats. Male Wistar Albino rats (n = 18) were randomly divided into three following groups: (1) normal control, (2) tetracycline‐treatment (200 mg kg−1 rat−1), and (3) tetracycline (200 mg kg−1 rat−1) + propolis (100 mg kg−1 rat−1) treatments. The ethanolic extract of propolis contained major phenolic acids as well as a flavonoid, rutin. Oral exposure to tetracycline caused severe hepatic and renal damage as indicated by significant alterations in liver marker enzymes in rat serum: bilirubin and protein concentrations, lipid profile, and markers of kidney function when compared with controls. The observed biochemical perturbations were accompanied by histopathological changes. Co‐administration with propolis extract, however, prevented the changes in biochemical parameters, as revealed by maintenance of cell membrane integrity and regulation of lipid profile and the conservation of the histoarchitecture. Practical applications Propolis is a resinous honeybee product which is becoming increasingly popular due to its potential contributions to human health. The phenolic compounds identified in propolis from Bangladesh were effective against tetracycline‐induced hepatic and renal toxicity. Propolis may be a promising natural product in reducing the effects of chronic liver and kidney damage.

show abstract

“…Curcumol (Cur), also known as turmeric alcohol, is a major component of essential oil (a type of oily liquid obtained by steam distillation) of the traditional Chinese medicine root of Rhizoma zedoariae that has been demonstrated to have anticancer, antibacterial, anti-inflammatory and antiviral effects (7,8). Previous studies have revealed that Cur has significant anti-liver cancer effects and serves an important role in liver protection (9,10). However, it is not as effective at treating liver cancer as traditional chemotherapeutic drugs, including fluorouracil (5-FU) and cisplatin (11,12).…”

Section: Introductionmentioning

confidence: 99%

Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate

You-wen

Guan

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

Liver-targeted drug delivery improves the efficacy of anti-liver cancer agents and reduces systemic toxicity by limiting the bioavailability of these drugs to within tumors. Liver targeting reagents with galactose residues, which selectively combine to asialoglyco protein receptors, have previously been used to improve liposome-encapsulated drug accumulation within liver cells. They lead to a reduction in liver cancer cell growth and have been used to cure certain hepatic diseases. In the present study, curcumol, which is the primary active component of Chinese traditional medicine Rhizoma zedoariae, was encapsulated in galactosylated-liposomes to enhance its anti-liver cancer efficacy. Galactosylated-liposomes and normal liposomes were labeled with propidium iodide. Galactosylated-liposomes with increasing concentrations of galactosylated-stearate (Gal-s) had a notably increased level of uptake in HepG2 cells (hepatoblastoma) compared with SGC-7901 (gastric cancer) and A549 (non-small cell lung cancer) cells. When the percentage of Gal-s reached 20%, liposome uptake plateaued. In the anti-liver cancer experiment, the anti-liver cancer efficacy of galactosylated-curcumol-liposomes increased significantly more compared with normal curcumol liposomes and free curcumol as indicated by cell survival rate and lactate dehydrogenase release rate. Collectively, these results demonstrate that galactosylated-liposomes are able to enhance the liver-targeting effect and anti-liver cancer efficacy of curcumol.

show abstract

Protective mechanism of turmeric ( Curcuma longa ) on carbofuran-induced hematological and hepatic toxicities in a rat model

Abstract: Turmeric supplementation could protect against CF-induced hematological perturbations and hepatic injuries in rats, plausibly by the up-regulation of antioxidant enzymes and inhibition of LPO to confer the protective effect.

Cited by 41 publications

References 46 publications

Evaluation of Curcuma zerumbet (Zingibaraceae) rhizome extracts sub-acute toxicity on Wistar rats

Evaluation of Curcuma zerumbet (Zingibaraceae) rhizome extracts sub-acute toxicity on Wistar rats

Ameliorative effects of ethanolic constituents of Bangladeshi propolis against tetracycline‐induced hepatic and renal toxicity in rats

Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate

Contact Info

Product

Resources

About