Protective immunity induced by oral vaccination with a recombinant Lactococcus lactis vaccine against H5Nx in chickens

Ren, Yi; Lu, Xuanyong; Yang, Zhonghe; Han, Lei

doi:10.1186/s12917-021-03109-z

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Similarly, the genera linked to better growth performance, improved immune response, better intestinal morphology, increased nutrient digestibility and improved energy metabolism, such as Bacillus spp. [ 51 , 52 , 53 , 54 ], Dietzia [ 55 ], Romboutsia [ 56 ], Sutterella [ 57 ], Lactococcus [ 58 , 59 ] and Olsenella [ 60 ], had a higher abundance in the AVG treatment group.…”

Section: Discussionmentioning

confidence: 99%

Controlled Intestinal Microbiota Colonisation in Broilers under the Industrial Production System

Kayal

Stanley

Radovanović

et al. 2022

Animals

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The concept of designer microbiota in chicken is focused on early exposure of the hatchlings to pathogen-free microbiota inoculum, limiting the early access to harmful and pathogenic microorganisms, thus promoting colonisation of the gut with beneficial and natural poultry microbiota. In this study, we controlled colonisation of the intestine in broiler chickens in a large-scale industrial setting via at-hatch administration of a commercial product containing a highly diverse microbiota originating from the chicken caecum. The treatment significantly transformed the microbiota membership in the crop, proventriculus, jejunum and caecum and significantly altered the taxa abundance in the jejunum, jejunum mucosa, and caecum estimated using PERMANOVA and unweighted and weighted UniFrac distances, respectively. The treatment also improved the growth rate in chickens with no significant alteration in feed conversion ratio. A comparison of inoculum product microbiota structure revealed that the inoculum had the highest Shannon diversity index compared to all investigated gut sections, and the number of Observed Species second only to the caecal community. PCoA plots using weighted or unweighted UniFrac placed the inoculum samples together with the samples from the caecal origin.

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Section: Discussionmentioning

confidence: 99%

Controlled Intestinal Microbiota Colonisation in Broilers under the Industrial Production System

Kayal

Stanley

Radovanović

et al. 2022

Animals

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“…Many and diverse microbial antigens produced in or surface-displayed on lactic acid bacteria have been able to elicit significant immune and often protective responses [96][97][98][99][100][101]. These bacteria do not only serve as microbial cell factories [102,103] but also as vaccine vectors [103,104], for orally and mucosally-administered formulations, as they are able to induce a potent immune response by expressing foreign antigens, while drawing a minimal response against themselves [105][106][107].…”

Section: Bacteriamentioning

confidence: 99%

Recombinant vaccines in 2022: a perspective from the cell factory

et al. 2022

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The last big outbreaks of Ebola fever in Africa, the thousands of avian influenza outbreaks across Europe, Asia, North America and Africa, the emergence of monkeypox virus in Europe and specially the COVID-19 pandemics have globally stressed the need for efficient, cost-effective vaccines against infectious diseases. Ideally, they should be based on transversal technologies of wide applicability. In this context, and pushed by the above-mentioned epidemiological needs, new and highly sophisticated DNA-or RNA-based vaccination strategies have been recently developed and applied at large-scale. Being very promising and effective, they still need to be assessed regarding the level of conferred long-term protection. Despite these fast-developing approaches, subunit vaccines, based on recombinant proteins obtained by conventional genetic engineering, still show a wide spectrum of interesting potentialities and an important margin for further development. In the 80’s, the first vaccination attempts with recombinant vaccines consisted in single structural proteins from viral pathogens, administered as soluble plain versions. In contrast, more complex formulations of recombinant antigens with particular geometries are progressively generated and explored in an attempt to mimic the multifaceted set of stimuli offered to the immune system by replicating pathogens. The diversity of recombinant antimicrobial vaccines and vaccine prototypes is revised here considering the cell factory types, through relevant examples of prototypes under development as well as already approved products.

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Recent Advances in Oral Vaccines for Animals

Zhong,

Chen,

Zhang

et al. 2024

Veterinary Sciences

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Compared to traditional injected vaccines, oral vaccines offer significant advantages for the immunization of livestock and wildlife due to their ease of use, high compliance, improved safety, and potential to stimulate mucosal immune responses and induce systemic immunity against pathogens. This review provides an overview of the delivery methods for oral vaccines, and the factors that influence their immunogenicity. We also highlight the global progress and achievements in the development and use of oral vaccines for animals, shedding light on potential future applications in this field.

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Protective immunity induced by oral vaccination with a recombinant Lactococcus lactis vaccine against H5Nx in chickens

Cited by 3 publications

References 38 publications

Controlled Intestinal Microbiota Colonisation in Broilers under the Industrial Production System

Controlled Intestinal Microbiota Colonisation in Broilers under the Industrial Production System

Recombinant vaccines in 2022: a perspective from the cell factory

Recent Advances in Oral Vaccines for Animals

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