Protective Immunity against Vibrio harveyi in Grouper Induced by Single Vaccination with Poly (Lactide-co-glycolide) Microparticles Releasing Pleurocidin Peptide and Recombinant Glyceraldehyde-3-phosphate Dehydrogenase

Liu, Shang-Pin; Chuang, Shu-Chun; Yang, Chung-Da

doi:10.3390/vaccines8010033

Cited by 1 publication

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pleurocidins, may help protect fish populations as immune response modulators. Researchers have already developed effective vaccine strategies for fish against Vibrio harveyi , whereby the AMP and protein adjuvants are encased in polymers [ 63 , 64 ]. One study found pleurocidins to confer long-term immunity against V. harveyi in grouper by promoting lymphocyte proliferation and TNF-α [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

“…Researchers have already developed effective vaccine strategies for fish against Vibrio harveyi , whereby the AMP and protein adjuvants are encased in polymers [ 63 , 64 ]. One study found pleurocidins to confer long-term immunity against V. harveyi in grouper by promoting lymphocyte proliferation and TNF-α [ 64 ]. Another study attempted to use a pleurocidin promoter to protect against VHSV, but found the promotor did not induce an effective response compared to other promotors [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Investigating Potential Applications of the Fish Anti-Microbial Peptide Pleurocidin: A Systematic Review

McMillan

Coombs

2021

Pharmaceuticals

View full text Add to dashboard Cite

The anti-microbial peptide (AMP) pleurocidin is found in winter flounder (Pseudopleuronectes americanus), an Atlantic flounder species. There is promising evidence for clinical, aquaculture, and veterinary applications of pleurocidin. This review provides an overview of the current literature available on pleurocidin to guide future research directions. By fully elucidating pleurocidin’s mechanism of action and developing novel treatments against pathogenic microbes, populations of flatfish and humans can be protected. This review consulted publications from PubMed and Environment Complete with search terms such as “pleurocidin”, “winter flounder”, and “antimicrobial”. The fish immune system includes AMPs as a component of the innate immune system. Pleurocidin, one of these AMPs, has been found to be effective against various Gram-positive and Gram-negative bacteria. More investigations are required to determine pleurocidin’s suitability as a treatment against antibiotic-resistant pathogens. There is promising evidence for pleurocidin as a novel anti-cancer therapy. The peptide has been found to display potent anti-cancer effects against human cancer cells. Research efforts focused on pleurocidin may result in novel treatment strategies against antibiotic-resistant bacteria and cancer. More research is required to determine if the peptide is a suitable candidate to be developed into a novel anti-microbial treatment. Some of the microbes susceptible to the peptide are also pathogens of fish, suggesting its suitability as a therapeutic treatment for fish species.

show abstract

Section: Resultsmentioning

confidence: 99%