Protective function ofex vivoexpanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression
Xiaokun Liu,
Rodrigo Gutierrez Jauregui,
Yvonne Lueder
et al.
Abstract:The adoptive transfer of virus-specific T cells (VSTs) represents a therapeutic option for viral infection treatment in immunocompromised patients. Before administration, ex vivo culture enables VST expansion. However, it is unclear how ex vivo expansion affects the circulation, homing, and intra-tissue migration of administered VSTs. We established a model of VST immunotherapy of acute cytomegalovirus infection using adoptive transfer of ex vivo expanded OT-I CD8 T cells (recognizing SIINFEKL peptide) into Ra… Show more
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