Protective efficiency of parsley (Petroselinum crispum) against oxidative stress, DNA damage and nephrotoxicity induced with anti- tuberculosis drugs

Ashry, Mahmoud; Atia, Ismail; Morsy, Fatma A.; Elmashad, Wael

doi:10.21608/jcbr.2020.45551.1077

Cited by 9 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous phytochemical analysis of Parsley revealed the presence of certain compounds such as flavonoids [40], carotenoids [41], ascorbic acid [42], and tocopherol [43]. These components of fresh Parsley leaves eliminate the superoxide anion in vitro and the hydroxyl radical, in addition to protecting against membrane oxidation induced by ascorbic acid [44].…”

Section: Discussionmentioning

confidence: 99%

The Protective Potential of Petroselinum crispum (Mill.) Fuss. on Paracetamol-Induced Hepatio-Renal Toxicity and Antiproteinuric Effect: A Biochemical, Hematological, and Histopathological Study

Nouioura,

Kettani,

Tourabi

et al. 2023

Medicina

View full text Add to dashboard Cite

Background and Objectives: Paracetamol overdose is a significant global issue due to its widespread use, which can lead to a lack of awareness regarding its potential side effects. Paracetamol can harm the liver, possibly resulting in liver failure. Conversely, this study employed extracts from Petroselinum crispum (PC), known for its rich content of bioactive compounds, with demonstrated antioxidant properties shown in previous research as well as protective effects against various diseases. The primary objective of this study was to investigate the potential protective effects of Petroselinum crispum on altered hematological and biochemical parameters in the blood of rats exposed to paracetamol. Materials and Methods: The study involved twenty Wistar rats divided into four groups. Different groups of male rats were administered PC extract at 200 mg/kg body weight daily for 15 days, along with a standard reference dose of paracetamol at 200 mg/kg. The study assessed hepatoprotection capacity by analyzing liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profiles. Renal safety was evaluated through creatinine, urea, uric acid, lactate dehydrogenase (LDH), and total protein. Additionally, histopathological examinations of the liver and kidneys were conducted. Results: Following Paracetamol overdose, there were reductions in hemoglobin levels, serum total protein, albumin, and uric acid. Paracetamol overdose also elevated levels of several blood biomarkers, including creatinine, urea, nitrogen, ALT, AST, triglycerides, LDH activity, white blood cell count, and platelet count compared to the control group. However, using an ethanolic extract of Petroselinum crispum significantly mitigated the severity of these alterations and the extent of the effect correlated with the dose administered. Parsley extract helped prevent proteinuria and low hemoglobin, which are common side effects of Paracetamol. Conclusions: Therefore, parsley may hold promise in managing liver and kidney conditions—particularly in addressing proteinuria. Ultimately, these results may have implications for human health by potentially mitigating paracetamol-induced renal, hepatic, and hematological toxicity.

show abstract

Section: Discussionmentioning

confidence: 99%

The Protective Potential of Petroselinum crispum (Mill.) Fuss. on Paracetamol-Induced Hepatio-Renal Toxicity and Antiproteinuric Effect: A Biochemical, Hematological, and Histopathological Study

Nouioura,

Kettani,

Tourabi

et al. 2023

Medicina

View full text Add to dashboard Cite

show abstract

“…The oral administration of parsley is effective in reducing stress-induced gastric injury by supporting the cellular antioxidant defense system (Akıncı et al, 2017). Ashry et al (2021) demonstrated that parsley extract may be as promising as nephroprotection against isoniazid and rifampicin nephrotoxicity through their antioxidant and radical scavenging activities.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

Swed J BioSci Res

View full text Add to dashboard Cite

Aspartame (ASP) is one of the most widely used artificial sweeteners in the world. It is densely added to a large variety of food and drink. Parsley oil (PO) is one of the herbs widely used in recipes of folk medicine. PO has antioxidant, anti-inflammatory, and antiapoptotic activities. The present study investigated the protective effects of PO against hematotoxicity, nephrotoxicity and hepatotoxicity induced by ASP in a male albino rat. Thirty-two rats were divided into four groups. Control group: rats were given distilled water; PO group: rats were given orally PO daily (0.5 mL/kg b.wt.), ASP group: rats were given orally oral ASP daily (500 mg/kg b.wt.), and ASP combination with PO group: rats were given orally ASP combination with PO daily for 30 days. At the end of the experiment, blood, liver, and kidney samples were collected for hematological, biochemical, and histological studies. The results showed that ASP induced significant increase in mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), lymphocytes, monocytes, alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate transaminase (AST), creatinine, urea, cholesterol, triglyceride, high density lipoprotein (HDL-c), and fasting blood glucose compared to control. While there is an insignificant change in red blood cells count (RBCs), hemoglobin (Hb), platelets count, white blood cells (WBCs) count, serum levels of uric acid in ASP versus control. The combination of ASP with PO showed significant decrease in MCHC, MCV, ALP, AST, ALT, creatinine, urea, cholesterol, triglyceride, HDL-c, and fasting blood glucose compared to ASP. The histological examination showed histopathological alterations in the liver tissue and renal tubules in the ASP group. In contrast, the liver and kidney tissues in ASP combination with the PO group appeared normal. In conclusion, PO protects liver, kidney, and blood from ASP toxicity in male rats. This protected effect may be due to pharmacological properties including antioxidant, hepatoprotective, neuroprotective, anti-diabetic activities of phenolic components in PO against ASP toxicity.

show abstract

“…Fresh-cut parsley (Petroselinum crispum (Mill.) Fuss), a ready-to-use ingredient or garnish for multiple dishes in home kitchens and restaurants, deserves interest for the beneficial effects that its main compounds exert on health [32][33][34]. It was chosen for this study because it is particularly rich in AA [31], and, compared to other minimally processed produce, it undergoes more rapid deterioration because of chopping, a mechanical wounding that causes a tremendous disruption of cells, inducing a release of nutrients, accelerating senescence and quality loss [4,10], enhancing bacterial growth [35] and, on the whole, strongly affecting its shelf-life.…”

Section: Introductionmentioning

confidence: 99%

et al. 2021

View full text Add to dashboard Cite

This work provides companies in the fresh-cut produce sector with an Ascorbate Bluetooth© Analyzer (ABA), a screen-printed sensor-based device for ascorbic acid (AA) detection, for quality control all along the supply chain. The amperometric detection of AA on fresh and fresh-cut parsley, under correct and incorrect storage temperature, allowed us to investigate the kinetics of AA decay in response to oxidative stress. The role of ascorbate oxidase (AOx) and ascorbate peroxidase (APx) was studied. ABA was used in situ by unskilled personnel. Treatments influenced AA decay kinetics, which were linear in fresh parsley, and non-linear in fresh-cut. Two hours at 28 °C immediately after chopping, the resilience of the fresh-cut parsley was reduced, even though the cold chain was restored. Two hours at −2 °C caused a rapid loss of AA until its complete decay after 72 h. Significant differences between treatments were observed in both the expression and activity of AOx and APx. ABA registered sudden changes of parsley AA following unpredicted variations of temperature during processing or transport. It was useful to remedy the effects of unexpected flaws in the cold chain, which can be proposed for quality preservation of different fresh-cut produce.

show abstract

Protective efficiency of parsley (Petroselinum crispum) against oxidative stress, DNA damage and nephrotoxicity induced with anti- tuberculosis drugs

Cited by 9 publications

References 24 publications

The Protective Potential of Petroselinum crispum (Mill.) Fuss. on Paracetamol-Induced Hepatio-Renal Toxicity and Antiproteinuric Effect: A Biochemical, Hematological, and Histopathological Study

The Protective Potential of Petroselinum crispum (Mill.) Fuss. on Paracetamol-Induced Hepatio-Renal Toxicity and Antiproteinuric Effect: A Biochemical, Hematological, and Histopathological Study

Untitled

An Ascorbate Bluetooth© Analyzer for Quality Control of Fresh-Cut Parsley Supply Chain

Contact Info

Product

Resources

About