Protective efficacy of Streptococcus iniae derived enolase against Streptococcal infection in a zebrafish model

Complete Molecular and Immunoprotective Characterization of Babesia microti Enolase

“…Moreover, enolase may also be an important candidate antigen for vaccines against pathogen infection (Pal-Bhowmick et al, 2007; Zhang et al, 2015, 2016; Mahana et al, 2016; Membrebe et al, 2016). It has been reported that mice immunized with r-Pfen antigen were strongly protected against infection when challenged with mouse malarial parasite Plasmodium yoelii (Pal-Bhowmick et al, 2007), therefore we also tested the protective properties of B. microti enolase.…”

“…Enolase has also been suggested to be a major immunogenic protein with antigenic properties, and could therefore be a suitable candidate vaccine for pathogen infection (Zhang et al, 2015; Mahana et al, 2016; Membrebe et al, 2016). Recently, enolase has been demonstrated satisfactory protective properties against Plasmodium spp.…”

Expression, purification, and biological characterization of <i>Anaplasma phagocytophilum</i> enolase

“…However, further research is needed in order to confirm ApEno's role during the bacterial infection process of host cells. Enolase has also been identified as an important candidate antigen for vaccines against pathogen infection (25)(26)(27)(28)(29). Therefore, further research is also required to evaluate ApEno's potential as a candidate vaccine target to control anaplasmosis infection.…”

Status of the development of a vaccine against Mycoplasma bovis

“…The surface expressed a-enolase protein of M. bovis has been characterized [45]. Its surface expression and binding to plasminogen combined with the fact that a-enolase of Streptococcus iniae has been shown to be protective in mice and zebra fish models [46,47], suggests that it has potential target for vaccine development in M. bovis but as yet, there have been no reports of the assessment of a -enolase in vaccine trials.…”