Protective Efficacy of Lambda-Cyhalothrin Treated Nets in Anopheles Gambiae Pyrethroid Resistance Areas of Côte D’ivoire

Henry, Marie‐Claire; Assi, Serge-Brice; Rogier, Christophe; Dossou-Yovo, J.; Chandre, Fabrice; Guillet, Pierre; Coriat, Pierre

doi:10.4269/ajtmh.2005.73.859

Cited by 142 publications

(106 citation statements)

References 11 publications

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“…7 Until now, there was no evidence to support the fact that pyrethroid resistance reduced the effectiveness of LLIN for controlling malaria at an operational level. 8 However, comparative experimental hut trials of lambdacyalothrin as ITN and IRS treatments in the coastal area of Benin, Ladji and Malanville in the north, indicated a major loss of efficacy associated with pyrethroid resistance in Anopheles gambiae Giles at Ladji, Benin. Carbamates (CARs) and organophosphates (OPs) are considered as promising alternatives to pyrethroids for vector control.…”

Section: Introductionmentioning

confidence: 99%

Indoor Use of Plastic Sheeting Impregnated with Carbamate Combined with Long-Lasting Insecticidal Mosquito Nets for the Control of Pyrethroid-Resistant Malaria Vectors

Djènontin¹,

Chandre²,

Dabiré³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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The combined efficacy of a long-lasting insecticidal net (LLIN) and a carbamate-treated plastic sheeting (CTPS) or indoor residual spraying (IRS) for control of insecticide-resistant mosquitoes was evaluated in experimental huts in Burkina Faso. Anopheles gambiae from the area is resistant to pyrethroids and to a lesser extent, carbamates. Relatively low mortality rates were observed with the LLIN (44%), IRS (42%), and CTPS (52%), whereas both combinations killed significantly more mosquitoes (~70% for LLIN + CTPS and LLIN + IRS). Blood feeding by An. gambiae was uninhibited by IRS and CTPS compared with LLIN (43%), LLIN + CTPS (58%), and LLIN + IRS (56%). No evidence for selection of the kdr and ace-1R alleles was observed with the combinations, whereas a survival advantage of mosquitoes bearing the ace-1R mutation was observed with IRS and CTPS. The results suggest that the combination of the two interventions constitutes a potential tool for vector-resistance management.

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Section: Introductionmentioning

confidence: 99%

Indoor Use of Plastic Sheeting Impregnated with Carbamate Combined with Long-Lasting Insecticidal Mosquito Nets for the Control of Pyrethroid-Resistant Malaria Vectors

Djènontin¹,

Chandre²,

Dabiré³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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“…However, an overall conclusion is that kdr status alone did not operationally reduce the effectiveness of pyrethroid IRS. Similarly a multivillage randomized control trial in Cote d'Ivoire showed that pyrethroid-treated LLIN efficacy was not adversely affected by kdr (20), although a study in Senegal suggested kdr had an effect on increased malaria transmission (21). (5) appeared to confirm a lack of effectiveness of the pyrethroid spray round.…”

Section: Resultsmentioning

confidence: 99%

Country-level operational implementation of the Global Plan for Insecticide Resistance Management

Hemingway

Vontas

Poupardin

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Malaria control is reliant on the use of long-lasting pyrethroidimpregnated nets and/or indoor residual spraying (IRS) of insecticide. The rapid selection and spread of operationally significant pyrethroid resistance in African malaria vectors threatens our ability to sustain malaria control. Establishing whether resistance is operationally significant is technically challenging. Routine monitoring by bioassay is inadequate, and there are limited data linking resistance selection with changes in disease transmission. The default is to switch insecticides when resistance is detected, but limited insecticide options and resistance to multiple insecticides in numerous locations make this approach unsustainable. Detailed analysis of the resistance situation in Anopheles gambiae on Bioko Island after pyrethroid resistance was detected in this species in 2004, and the IRS program switched to carbamate bendiocarb, has now been undertaken. The pyrethroid resistance selected is a target-site knock-down resistance kdr-form, on a background of generally elevated metabolic activity, compared with insecticide-susceptible A. gambiae, but the major cytochrome P450-based metabolic pyrethroid resistance mechanisms are not present. The available evidence from bioassays and infection data suggests that the pyrethroid resistance mechanisms in Bioko malaria vectors are not operationally significant, and on this basis, a different, long-lasting pyrethroid formulation is now being reintroduced for IRS in a rotational insecticide resistance management program. This will allow control efforts to be sustained in a cost-effective manner while reducing the selection pressure for resistance to nonpyrethroid insecticides. The methods used provide a template for evidence-based insecticide resistance management by malaria control programs. M alaria control activities in Africa have been scaled up during the last decade. Disease control is predominantly dependent on the distribution and use of pyrethroid-impregnated long lasting insecticide-treated nets (LLINs) and/or indoor residual spraying (IRS) of insecticides. The choice of insecticides for IRS is currently limited to four classes with only two modes of action. One of these insecticide classes, pyrethroids, is also the only class recommended for use by the World Health Organization (WHO) on LLINs. The recent rapid selection and spread of pyrethroid resistance in malaria vectors has stimulated the WHO to develop a Global Plan for Insecticide Resistance Management (1), encouraging countries to plan and implement insecticide resistance management strategies and to underpin these strategies with proper, timely entomological resistance monitoring and effective data management. This must be implemented in the short term at the same time mediumto long-term efforts are made to expand the available insecticide choice (2). To be effective, resistance management plans need to be closely aligned with local evidence supported by an effective monitoring system.Here we detail how this process has been un...

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“…gambiae s.s. [40,165]. In Côte d'Ivoire, ITN-randomised controlled trials demonstrated a significant reduction on the entomological inoculation rate (55%) [166] and on malaria incidence in children <5 (56%) [167] despite the presence of kdr-based pyrethroid resistance.…”

Section: Resistance and Vector Controlmentioning

confidence: 99%

Optimizing Strategic Insecticide Resistance Management Planning in Malaria Vectors

Chanda¹

2016

Insecticides Resistance

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In the past decade, there has been rapid scale-up of insecticide-based malaria vector control in the context of integrated vector management (IVM). But, the continued efficacy of vector control interventions is threatened by the selection of insecticide resistance. Evidence of insecticide resistance operationally undermining malaria vector control programmes is invariably mounting and is resulting in policy changes. Monitoring and management of resistant disease vectors is essential to limit the selection and spread of insecticide resistance and to maintain the effectiveness of vector control. Thus, countries are encouraged to implement pre-emptive insecticide resistance management (IRM) strategies against malaria vectors according to the Global Plan for IRM. However, substantial challenges for implementation exist at country level. The IVM strategy provides a potential platform that could be exploited for enhanced national strategic IRM planning and operationalisation. Nevertheless, significant coordinated response among stakeholders and political commitment is needed for timely and effective policy implementation within the context of a national health system.

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Protective Efficacy of Lambda-Cyhalothrin Treated Nets in Anopheles Gambiae Pyrethroid Resistance Areas of Côte D’ivoire

Cited by 142 publications

References 11 publications

Indoor Use of Plastic Sheeting Impregnated with Carbamate Combined with Long-Lasting Insecticidal Mosquito Nets for the Control of Pyrethroid-Resistant Malaria Vectors

Indoor Use of Plastic Sheeting Impregnated with Carbamate Combined with Long-Lasting Insecticidal Mosquito Nets for the Control of Pyrethroid-Resistant Malaria Vectors

Country-level operational implementation of the Global Plan for Insecticide Resistance Management

Optimizing Strategic Insecticide Resistance Management Planning in Malaria Vectors

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