Protective efficacy of <i><scp>N</scp>igella sativa</i> seeds and oil against columnaris disease in fishes

Mohammed, Haitham H.; Arias, Cova R.

doi:10.1111/jfd.12402

Cited by 19 publications

(7 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our current study displays that nephrotoxicity induced by diabetes could be rescued by the treatment with Ginkgo biloba extract and magnetized water. Likewise, a concomitant reduction in nephrotoxic effects after Ginkgo biloba treatment was mentioned before [ 14 – 16 , 31 – 34 ] as well as magnetized water treatment [ 19 , 21 , 25 – 27 ].…”

Section: Discussionmentioning

confidence: 87%

Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

Zayed

Saleh

Gomaa

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

We aimed in our current study to explore the protective effect of Ginkgo biloba (GB) and magnetized water (MW) against nephrotoxicity associating induced type 2 diabetes mellitus in rat. Here, we induced diabetes by feeding our lab rats on a high fat-containing diet (4 weeks) and after that injecting them with streptozotocin (STZ). We randomly divided forty rats into four different groups: nontreated control (Ctrl), nontreated diabetic (Diabetic), Diabetic+GB (4-week treatment), and Diabetic+MW (4-week treatment). After the experiment was finished, serum and kidney tissue samples were gathered. Blood levels of glucose, triglycerides, cholesterol, creatinine, and urea were markedly elevated in the diabetic group than in the control group. In all animals treated with GB and MW, the levels of urea, creatinine, and glucose were significantly reduced (all P < 0.01). GB and MW attenuated glomerular and tubular injury as well as the histological score. Furthermore, they normalized the contents of glutathione reductase and SOD2. In summary, our data showed that GB and MW treatment protected type 2 diabetic rat kidneys from nephrotoxic damages by reducing the hyperlipidemia, uremia, oxidative stress, and renal dysfunction.

show abstract

Section: Discussionmentioning

confidence: 87%

Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

Zayed

Saleh

Gomaa

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…14 The seeds are sold in the markets to be used as a condiment and native medicine. Its main chemical constituents are Thymoquinone (TQ), dithymoquinone, xed oil (32-40 %), saponin (Mohammed & Arias, 2016). The pharmacological activity of Nigella sativa is because of quinine constituent, of which TQ is the most part bottomless (Chehl et al, 2009), TQ possess anticonvulsant activity antioxidant, anti-…”

Section: Introductionmentioning

confidence: 99%

Novel Insight into Potential Leishmanicidal Activities of Transdermal Patches of Nigella Sativa: Formulation Development, Physical Characterizations, and In vitro/In vivo Assays

Khan

Asmat

Khan

et al. 2021

ASSAY and Drug Development Technologies

View full text Add to dashboard Cite

Cutaneous Leishmaniasis (CL) is the most common type of Leishmaniasis which annually affects 1.5 million people worldwide. About 90% of cases are reported from countries such as Iran, Afghanistan, Pakistan, Iraq, and Saudi Arabia. The purpose of the present study was to fabricate transdermal patches of Nigella sativa (NS), characterize and to check its in vitro in vivo anti-Lieshmanial activity. Hydroalcohlic extract was analyzed for preliminary phytochemicals. Five formulations of transdermal patches (NS1, NS2, NS3, NS4 and NS5) were prepared by solvent evaporation method. The optimized formulation NS5 was characterized for FTIR, smoothness, brittleness, clarity, thickness, folding endurance, uniformity of weight, percent moisture content, in-vitro drug release, release kinetics, ex vivo drug permeation and invitro anti-Lieshmanial activity. In vivo anti-Lieshmanial activity was assessed in 30 patients (n = 30) suffering from CL. The FTIR studies showed no incompatibility among the active extract and polymers. In vitro anti-Lieshmanial assay was 194.6 ± 1.88 % as compared to standard drug (p > 0.05) and in vivo anti-Lieshmanial activity was 75 %. The drug release after 24 hours was 87.0 ± 0.94% in NS5 which showed non-Fickian diffusion mechanism while drug permeation across rabbit skin after 24 hours was up to 80.0 ± 0.91%. The results concluded that problems related to the medications parenterally used for Lieshmanial treatment can be managed by applying extract of Nigella sativa seeds in the form of transdermal patch. parasitic, anti-in ammatory, anti-cancer, antibacterial and antifungal activity. 15 Based on the above justi cation, the present study was designed with the aim to formulate and characterize transdermal patches of Nigella sativa extract for possible anti Lieshmanial activity in vitro and in vivo. Materials And MethodsMethanol, HPMC, Ethyl Cellulose, PVP, PVA (polymers), Propylene glycol, Tween-80, DMSO were purchased from Sigma Aldrich, Germany. Nigella sativa seeds Extract were purchased from local market of D. I. Khan, Pakistan. Benedict's reagent & Wagner's reagent (Iodine Reagent), Chloroform and Distilled Water were obtained from

show abstract

“…Dicentrarchus labrax fed with 1% Thymus vulgaris supplemented diet has showed higher protein contents in its fillets [38]. Black seeds are a rich source of several essential amino acids (methionine, threonine, lysine, arginine, glutamic acid, leucine, tyrosine and proline) and (16)(17)(18)(19).9%) proteins [49] (pp. 1314-1315).…”

Section: Discussionmentioning

confidence: 99%

“…Several researchers have reported antifungal [16] (pp. [31][32][33][34][35], antimicrobial [17] (pp. 693-703), antioxidant [18] (pp.…”

Section: Introductionmentioning

confidence: 99%

Dietary Black Seed Effects on Growth Performance, Proximate Composition, Antioxidant and Histo-Biochemical Parameters of a Culturable Fish, Rohu (Labeo rohita)

Latif

Faheem

Asmatullah

et al. 2020

Animals

View full text Add to dashboard Cite

This feeding trial was conducted to investigate the effects of dietary black seed (Nigella sativa) supplementation on the growth performance, muscles proximate composition, antioxidant and histo-biochemical parameters of rohu (Labeo rohita). Fingerlings (8.503 ± 0.009 g) were fed on 0.0%, 1% and 2.5% black seed supplemented diets for 28 days. Fish sampling was done on the 7th, 14th, 21st and 28th day of experiment. The results of the present study indicated that black seed supplementation significantly increased growth performance and muscles protein contents of rohu over un-supplemented ones. Lipid peroxidation levels significantly decreased in all the studied tissues (liver, gills, kidney and brain) of black seed fed rohu, whereas the antioxidant enzymes (catalase, glutathione-S-transferase, glutathione peroxidase and reduced glutathione) activities were increased in all the studied tissues of black seed supplemented rohu at each sampling day. The hepatic-nephric marker enzymes levels were decreased for black seed fed rohu. The present study showed that tested black seed levels are safe for rohu. Black seed is cheaply available in local markets of Pakistan; therefore, based on the results of the present study, it is suggested that black seed has potential to be used as natural growth promoter and antioxidant in the diet of rohu.

show abstract

Protective efficacy of Nigella sativa seeds and oil against columnaris disease in fishes

Cited by 19 publications

References 48 publications

Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

Novel Insight into Potential Leishmanicidal Activities of Transdermal Patches of Nigella Sativa: Formulation Development, Physical Characterizations, and In vitro/In vivo Assays

Dietary Black Seed Effects on Growth Performance, Proximate Composition, Antioxidant and Histo-Biochemical Parameters of a Culturable Fish, Rohu (Labeo rohita)

Contact Info

Product

Resources

About