Protective Efficacy of Combined Administration of Vitamins C and Curcumin on Cypermethrin - Induced Oxidative Stress in Male Albino Rats.

Abstract

Back Ground: Cypermethrin (CPM) is non-systematic type II synthetic pyrethroid, commonly used for pest control in livestock, forestry, horticulture, household, public and animal health services, private homes, and animal husbandry. By scavenging free radicals and modulating antioxidant protection mechanism, plant phytochemicals (vitamin C and Curcumin) are known to exert their protective impact, Aim: The current research aimed to examine the ameliorative effect of combining curcumin with prevention of vitamin C against the toxic effects of cypermethrin. Method: Four groups of ten male rats each,-ve control, +ve control group (200 mg curcumin and 100 mg vit. C/ kg bw), cypermethrin alone (200 mg / Kg bw), and cypermethrin supplemented with the protective antioxidants orally intubated for 28-days. Result: Oral cypermethrin induced a significant increase in MDA and PC in serum, liver and brain as the oxidant biomarkers. While the antioxidant biomarkers (CAT, GSH or SH protein) were significantly decreases in serum and brain tissues. The phase II biotransformation GST was increased significantly in brain and liver tissues. ATPase activity declined significantly in brain tissue only. Conclusion: we can deduce that, cypermethrin induce oxidative stress in serum and organs tissues of male rats and the protective role curcumin and vit. C was more evident on serum, brain than liver.

Neuro-protective and redox potential of troxerutin against cypermethrin-induced neurotoxicity and oxidative stress in mice

“…The decrease in CAT activity might be due to the utilization of enzymes in overcoming the effect of oxidative stress (Ince et al 2012). Our study aligns with the other studies, Ziada et al (2020) showed that oral supplementation of 200 mg/kg/b.w. CYP for 28 days brings about oxidative stress in the serum and brain, as indicated by reduced CAT activity.…”

Curcumin as a Potential Antioxidant in Stress Regulation of Terrestrial, Avian, and Aquatic Animals: A Review

“…CPM leads to a significant increase in MDA and protein carbonyl (PC) levels in serum, the liver, and the brain, while antioxidant biomarkers are significantly reduced in serum and brain tissues. Ziada et al [ 35 ] indicated that plant phytochemicals such as vitamin C and curcumin play a protective role against cypermethrin-induced oxidative stress in serum, the brain, and the liver. Curcumin, in addition to its antioxidative and free-radical-scavenging abilities, also enhances the activity of other antioxidants [ 35 ].…”

“…Ziada et al [ 35 ] indicated that plant phytochemicals such as vitamin C and curcumin play a protective role against cypermethrin-induced oxidative stress in serum, the brain, and the liver. Curcumin, in addition to its antioxidative and free-radical-scavenging abilities, also enhances the activity of other antioxidants [ 35 ]. Heavy metals such as cadmium (Cd) can cause damage to various organ systems in animals after long-term exposure.…”