Protective efficacy of a single immunization with capripoxvirus-vectored recombinant peste des petits ruminants vaccines in presence of pre-existing immunity

Caufour, Philippe; Rufael, Tesfaye; Lamien, Charles Euloge; Lancelot, Renaud; Kidane, Menbere; Awel, Dino; Sertse, Tefera; Kwiatek, Olivier; Libeau, Geneviève; Sahle, Mesfin; Diallo, Adama; Albina, Emmanuel

doi:10.1016/j.vaccine.2014.05.025

Cited by 46 publications

(37 citation statements)

References 49 publications

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“…For vectored vaccines, the presence of pre-existing immunity against the vector, i.e. in the case of capripox combination vaccines [59], has also not been thoroughly examined in the field. In all these cases, further research is required to convert their clear potential into applicable field vaccines.…”

Section: Development and Application Of Pprv Vaccinesmentioning

confidence: 99%

“…Significant benefits and cost improvements could be achieved through simultaneous vaccination against several small ruminant diseases. This could be addressed either by recombinant vaccines such as the capripox/PPRV vaccine [59] or by combined vaccination against PPR and sheep goat pox, which has already been shown to be effective [58]. Integrated control campaigns of this kind are already being implemented in some countries, e.g.…”

Section: Development and Application Of Pprv Vaccinesmentioning

confidence: 99%

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Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Baron

Diop

Njeumi

et al. 2017

Journal of General Virology

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Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia. Despite the availability of an efficacious and cheap live-attenuated vaccine, the virus has continued to spread, with its range stretching from Morocco in the west to China and Mongolia in the east. Some of the world's poorest communities rely on small ruminant farming for subsistence and the continued endemicity of PPRV is a constant threat to their livelihoods. Moreover, PPRV's effects on the world's population are felt broadly across many economic, agricultural and social situations. This far-reaching impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) to develop a global strategy for the eradication of this virus and its disease. PPRV is a morbillivirus and, given the experience of these organizations in eradicating the related rinderpest virus, the eradication of PPRV should be feasible. However, there are many critical areas where basic and applied virological research concerning PPRV is lacking. The purpose of this review is to highlight areas where new research could be performed in order to guide and facilitate the eradication programme. These areas include studies on disease transmission and epidemiology, the existence of wildlife reservoirs and the development of next-generation vaccines and diagnostics. With the support of the international virology community, the successful eradication of PPRV can be achieved.

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Section: Development and Application Of Pprv Vaccinesmentioning

confidence: 99%

Section: Development and Application Of Pprv Vaccinesmentioning

confidence: 99%

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Baron

Diop

Njeumi

et al. 2017

Journal of General Virology

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“…However, DIVA vaccine candidates would need to be evaluated in comparison with conventional vaccines for the full range of vaccine attributes (e.g., efficacy, impact on virus shedding and transmission, duration of immunity, range of protection, safety, minimum dose, ease of production, cost) in addition to diagnostic advantages. Candidate vaccines for DIVA technologies include capripox (30,31) and adenovirusvectored vaccines (18,32). Prior exposure to capripox reduced the immune responses to the PPR Ags in vaccinates and, in the one study where challenge was carried out, incomplete protection against clinical disease.…”

Section: Suitable Vaccines and Diagnostics Are Availablementioning

confidence: 99%

The Opportunity To Eradicate Peste des Petits Ruminants

Mariner

Jones

Rich

et al. 2016

The Journal of Immunology

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Peste des petits ruminants (PPR) is a highly infectious disease of sheep and goats that is caused by PPR virus, a member of the genus Morbillivirus that includes the viruses that cause rinderpest (RP) in cattle. RP was the first animal disease to be globally eradicated in 2011 and is only the second disease, after smallpox, to have ever been eradicated. PPR is one of the principal constraints to small ruminant production in Africa, Asia, and the Middle East. The epidemiology of PPR and RP as well as the technologies available for their diagnosis and control are similar. The conditions that favored the eradication of RP are also largely present for PPR. In this work, we outline the evolving strategy for eradication in light of current opportunities and challenges, as well as the lessons from other eradication programs in animal and human health. The global PPR situation and technology for its control are summarized. A strategy based on the lessons from previous eradication efforts that integrate epidemiology, social science, and economics as tools to target and motivate vaccination is summarized. Major aspects of the cost and benefit-cost analysis of the indicated program are presented. The overall undiscounted cost of eradication was estimated as $3.1 billion, and the benefit-cost ratio for the most likely scenario was estimated at 33.8. We close with a discussion of the possible next steps.

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“…PPRV H protein has also been shown to be effective in inducing both humoral and cell-mediated immune responses. Recombinant vector viruses expressing H alone or combined with F, another PPRV glycoprotein, can induce high levels of antibodies and protect goats and sheep from experimental challenge with pathogenic PPRV (Caufour et al, 2014;Holzer et al, 2016). However, multi-epitope based recombinant vaccines offer numerous advantages compared to the complete protein including cost-effective production, multi-valency, and stability under different conditions.…”

Section: Discussionmentioning

confidence: 99%

Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus hemagglutinin protein

Zhu

Gao

et al. 2017

Veterinary Microbiology

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Hemagglutinin protein (H), one of the two glycoproteins of peste des petits ruminants virus (PPRV), binds to its receptor on the host cell and acts as a major antigen that induces and confers highly protective immunity in the host. In order to delineate the epitopes on H protein, fine epitope mapping and conservation analysis of linear B-cell epitopes (BCEs) on PPRV H has been undertaken using biosynthetic peptides and rabbit anti-PPRV H sera. Thirteen linear BCEs were identified and their corresponding minimal motifs were located on the H protein of PPRV China/Tibet/Geg/07-30. Conservation analysis indicated that two of the 13 minimal motifs were conserved among 52 PPRV strains. Nine of the 13 peptides containing the minimal motifs were recognized using anti-PPRV serum from a goat immunized with PPRV vaccine strain Nigeria 75/1. Identified epitopes and their motifs improve our understanding of the antigenic characteristics of PPRV H and provide a basis for the development of epitope-based diagnostic assays and multiple epitopes vaccine.

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Protective efficacy of a single immunization with capripoxvirus-vectored recombinant peste des petits ruminants vaccines in presence of pre-existing immunity

Cited by 46 publications

References 49 publications

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

The Opportunity To Eradicate Peste des Petits Ruminants

Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus hemagglutinin protein

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