Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity

Alibakhshi, Tuba; Khodayar, Mohammad Javad; Khorsandi, Layasadat; Rashno, Mohammad; Zeidooni, Leila

doi:10.1016/j.biopha.2018.05.085

Cited by 58 publications

(32 citation statements)

References 57 publications

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“…1 month of ginger supplementation and antitubercular treatment significantly lower MDA concentration compared to control group [18]. Another study shows that zingerone is a ginger component that suppresses oxidative stress and inflammation in nephrotoxicity rat model [19]. Grape skin extract [20] and extra virgin olive oil [21] are also associated with preventive and therapeutic resource for lung inflammation and oxidative stress caused by cigarette smoke.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Red Ginger Ethanol Extract on Blood MDA Level of White Male Wistar Strain Rats Induced with Cigarette Smoke

Ratriantari¹,

Suradi²,

Probandari³

2019

Proceedings of the Proceedings of the 1st Seminar and Workshop on Research Design, for Education, Social Science, Arts, and Hum

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Cigarette smoke causes lipid peroxidation and results in an increase of malondialdehyde (MDA) level in blood that could finally lead to decreased lung function and respiratory disease. Herbs and spices like red ginger are known to have beneficial compounds for health. The aim of this study is to prove the effect of red ginger ethanol extract on blood MDA level of white male Wistar strain rats induced with cigarette smoke. 32 white male rats were divided into 4 groups. Group 1 was the negative control group, group 2 was the positive control group, group 3 was the one induced with cigarette smoke and 250 mg of red ginger ethanol extract and group 4 was induced with cigarette smoke and 500 mg of red ginger ethanol extract. Blood samples were taken on the baseline (day 0) and day 7 to be analyzed. MDA levels were measured using spectrophotometer. One Way ANOVA test and post hoc Tukey test were used to compare with the negative group. The study show significant differences (p=0,000) and the results were KN= 1,55; KP=4,45;J1=2,81;J2=1,65 (nmol/ml). Both doses of red ginger ethanol extract decrease blood MDA levels after 7 days treatment. Finally, it concludes that antioxidant content in red ginger ethanol extract can decrease MDA level.

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Section: Resultsmentioning

confidence: 99%

The Effect of Red Ginger Ethanol Extract on Blood MDA Level of White Male Wistar Strain Rats Induced with Cigarette Smoke

Ratriantari¹,

Suradi²,

Probandari³

2019

Proceedings of the Proceedings of the 1st Seminar and Workshop on Research Design, for Education, Social Science, Arts, and Hum

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“…Ginger supplementation (500 mg/kg) in mice with a hyperlipidic diet was able to decrease the serum levels of IL‐6 and TNF‐α (Ahmad et al, ). Zingerone also decreases nephritis by decreasing the levels of TNF‐α (Alibakhshi, Khodayar, Khorsandi, Rashno, & Zeidooni, ), IL‐1β, and IL‐6 in the kidneys of diabetic rats supplemented with ethanolic extract of Z. officinale (Al Hroob et al, ). Ginger extract and 6‐gingerol are capable of decreasing TNF‐α levels in the adipose tissue of animals fed a hyperlipidic diet (Nammi et al, ).…”

Section: Ginger As a Nutraceuticalmentioning

confidence: 99%

“…Aged mice supplemented with 6‐gingerol showed increased activity of GSH and SOD enzymes and expression of CAT, GPx1, SOD1, SOD2, and SOD3 (Li et al, ). Finally, zingerone is also capable of decreasing cisplatin‐induced nephrotoxicity by decreasing MDA levels and increasing GSH, GPx, and CAT activity (Alibakhshi et al, ).…”

Section: Ginger As a Nutraceuticalmentioning

confidence: 99%

Ginger and avocado as nutraceuticals for obesity and its comorbidities

Tramontin

Luciano

Marques

et al. 2020

Phytotherapy Research

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Obesity is a worldwide epidemic and is one of the factors involved in the etiology of type 2 diabetes mellitus. Obesity induces low-grade inflammation and oxidative stress. The treatment for obesity involves changes in diet, physical activity, and even medication and surgery. Currently, the use of nutraceutical compounds is associated with health benefits. Ginger and avocado are used for many people all around the world; however, its effect as a nutraceutical compound is less known by the general population. For this reason, we searched information of the literature to point its effects on distinct mechanisms of defense against the obesity its comorbidities. The present review aimed showing that these nutraceuticals may be useful in obesity treatment. Reports have shown that ginger and avocado induce antioxidant and antiinflammatory effects by improving enzymatic activity and modulating obesity-related impairments in the anti-inflammatory system in different tissues, without side effects.Furthermore, ginger and avocado were found to be effective in reversing the harmful effects of obesity on blood lipids. In conclusion, on the basis of the positive effects of ginger and avocado in in vitro, animal, and human studies, these nutraceuticals may be useful in obesity treatment. K E Y W O R D Sdiabetes treatment, inflammation, obesity, oxidative stress, phytotherapeutic approach, unhealthy diet

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“…Zingerone (ZO; 4-para methoxy-4-hydroxyphenyl-2-butanone) has antioxidant, anti-inflammatory, and antiapoptotic effects [15] that are presumed to be related to its protective effects against radiationinduced intestinal injury [16], lipopolysaccharide-induced liver damage [17], and sepsis-triggered nephrotoxicity [18]. Moreover, ZO has protective effects against CXP-induced toxicities, such as nephrotoxicity [15,19], hepatotoxicity [20], cardiotoxicity [21], and ovarian and uterine toxicity [22]. Because the molecular mechanisms underlying CXP-induced nephrotoxicity overlap with those underlying CXP-induced ototoxicity [23], it would be reasonable to expect that ZO has otoprotective effects against CXP-induced ototoxicity.…”

Section: Introductionmentioning

confidence: 99%

Otoprotective Effects of Zingerone on Cisplatin-Induced Ototoxicity

Lee

et al. 2020

IJMS

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Previous studies have described the effects of zingerone (ZO) on cisplatin (CXP)-induced injury to the kidneys, liver, and other organs but not to the cochlea. This study aimed to investigate the effects of ZO on CXP-induced ototoxicity. Eight-week-old Sprague–Dawley rats were used and divided into a control group, a CXP group, and a CXP + ZO group. Rats in the CXP group received 5 mg/kg/day CXP intraperitoneally for five days. Rats in the CXP + ZO group received 5 mg/kg/day CXP intraperitoneally for five days and 50 mg/kg/day ZO intraperitoneally for seven days. Auditory brainstem response thresholds (ABRTs) were measured before (day 0) and after (day 10) drug administration. Cochlear histology was examined using hematoxylin and eosin (H&E) staining and cochlear whole mounts. The expression levels of cytochrome P450 (CYP)1A1, CYP1B1, inducible nitric oxide synthase (iNOS), nuclear factor kappa B (NFκB), tumor necrosis factor alpha (TNFα), and interleukin 6 (IL6) were estimated using quantitative reverse transcription-polymerase chain reaction. The expression levels of heme oxygenase 1 (HO1) and caspase 3 were analyzed via Western blotting. The auditory thresholds at 4, 8, and 16 kHz were attenuated in the CXP + ZO group compared with the CXP group. The mRNA expression levels of CYP1A1, CYP1B1, iNOS, NFκB, TNFα, and IL6 were lower in the CXP + ZO group than in the CXP group. The protein expression levels of HO1 and caspase 3 were lower in the CXP + ZO group than in the CXP group. Cotreatment with ZO exerted otoprotective effects against CXP-induced cochlear injury via antioxidative and anti-inflammatory activities involving CYPs, iNOS, NFκB, and TNFα.

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Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity

Cited by 58 publications

References 57 publications

The Effect of Red Ginger Ethanol Extract on Blood MDA Level of White Male Wistar Strain Rats Induced with Cigarette Smoke

The Effect of Red Ginger Ethanol Extract on Blood MDA Level of White Male Wistar Strain Rats Induced with Cigarette Smoke

Ginger and avocado as nutraceuticals for obesity and its comorbidities

Otoprotective Effects of Zingerone on Cisplatin-Induced Ototoxicity

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