Protective effects of Z 4003 on pulmonary endothelial cell damage induced by oxidant lung injury

Sala, Roberto; Moriggi, Ermanno; Chiarino, D.; Carenzi, A.

doi:10.1016/0014-2999(90)94269-4

Cited by 14 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NAC is a glutathione precursor that is commonly used as an antidote for acetaminophen overdose. In addition to augmenting glutathione synthesis, NAC has oxygen radical scavenging properties, 43 and NAC therapy has been examined in several clinical studies of ARDS patients with modest but encouraging results. In one trial of 66 patients with ARDS, NAC therapy was associated with a small increase in lung compliance compared with the control group but did not affect the survival rate.…”

Section: Mechanisms Of Alcohol-induced Susceptibility To Lung Injurymentioning

confidence: 99%

Alcohol Abuse and Acute Lung Injury: Epidemiology and Pathophysiology of a Recently Recognized Association

Guidot

Hart

2005

Journal of Investigative Medicine

View full text Add to dashboard Cite

Alcohol is the most commonly used and abused drug in the United States. The deleterious health effects of alcohol can be attributed both to its acute intoxicating effects, which result in temporary impairment of judgment and motor skills, and to its more chronic and toxic effects on the liver, pancreas, heart, and brain, all of which may result in irreversible organ damage. Although recognized for more than a century as a major risk factor for pneumonia, alcohol abuse was until recently perceived to have no significant effects on lung structure and/or function. However, within the past decade, epidemiologic studies have revealed that alcohol abuse independently increases the risk of acute respiratory distress syndrome (ARDS) two- to fourfold in patients with sepsis or trauma and may play a role in ARDS pathogenesis in as many as half of all patients with the syndrome. Although alcohol abuse alone does not cause acute lung injury, it renders the lung susceptible to dysfunction in response to the inflammatory stresses of sepsis, trauma, and other clinical conditions recognized to cause ARDS. Recent investigations in both animal models of chronic ethanol ingestion and in human subjects with a history of alcohol abuse have explored this previously unrecognized connection between alcohol and acute lung injury and have uncovered multiple derangements, which we now characterize as the "alcoholic lung." This review summarizes the epidemiologic association between alcohol abuse and acute lung injury and the recent experimental findings that are unraveling the underlying pathophysiology.

show abstract

Section: Mechanisms Of Alcohol-induced Susceptibility To Lung Injurymentioning

confidence: 99%

Alcohol Abuse and Acute Lung Injury: Epidemiology and Pathophysiology of a Recently Recognized Association

Guidot

Hart

2005

Journal of Investigative Medicine

View full text Add to dashboard Cite

show abstract

“…Accurate identifi cation of affected lungs in patients with pulmonary emphysema is important for diagnostic and therapeutic strategies [1][2][3][4][5][6]. Because alveolar destruction and hypoxic vasoconstriction secondary to hypoventilation associated with airway obstruction signifi cantly impair regional perfusion [1,7], perfusion single-photon emission computed tomography (SPECT) may more accurately identify emphysematous lungs than morphologic computed tomography (CT) [8].…”

Section: Introductionmentioning

confidence: 99%

Assessment of anatomic relation between pulmonary perfusion and morphology in pulmonary emphysema with breath-hold SPECT-CT fusion images

Suga¹,

Kawakami²,

Iwanaga

et al. 2008

Ann Nucl Med

View full text Add to dashboard Cite

show abstract

“…In groups B-E (n = 5 in each group), the [15,16], nitroglycerin [17,18] and N-acetylcystein [19][20][21], three compounds that are expected to protect vascular endothelium.…”

Section: Experimental Groupsmentioning

confidence: 99%

Mitochondrial Injuries in Rat Lungs Preserved for 17 h: An Ultrastructural Study

Ueda

Kosaka²,

Hirata³

et al. 1999

Eur Surg Res

View full text Add to dashboard Cite

Mitochondria of the small vasculature endothelial cells were examined in preserved rat lungs before and after reperfusion, and the ultrastructural changes were correlated with pulmonary function after reperfusion. Rat lungs were flushed with perfusate and prostaglandin E1 and divided into five groups (n = 5 in each group): group A, normal control group; group B, University of Wisconsin solution; group C, Euro-Collins solution; group D, ET-Kyoto solution, and group E, new ET-Kyoto solution. After preservation at 4°C for 17 h, the left lungs were reperfused at 37°C for 60 min. Tissue was sampled and mitochondria of the small vasculature endothelial cells were ultrastructurally analyzed by transmission electron microscopy before and after reperfusion. The ultrastructure of the mitochondria was well maintained in groups A, B and E before and after reperfusion. In group C, the number of severely degenerated mitochondria in the sectional area of 100 μm² before reperfusion was 18.0 ± 3.9, which was significantly larger than in the other groups (p < 0.01), and the total number of mitochondria significantly decreased with reperfusion (from 24.8 ± 3.5 to 8.2 ± 2.4, p < 0.05). In group C, the shunt fraction, mean pulmonary arterial pressure and the wet-dry ratio of the lung tissue after reperfusion C were significantly higher than in the other groups (p < 0.05; 76.3 ± 1.5%, 54.8 ± 4.2 mm Hg, and 20.6 ± 2.5, respectively). A positive correlation was found between the percentage of the mitochondrial degeneration before reperfusion and the physiological parameters after reperfusion. Mitochondrial damage associated with cold ischemia is probably involved in lung injury caused by cold preservation and reperfusion.

show abstract

Protective effects of Z 4003 on pulmonary endothelial cell damage induced by oxidant lung injury

Cited by 14 publications

References 0 publications

Alcohol Abuse and Acute Lung Injury: Epidemiology and Pathophysiology of a Recently Recognized Association

Alcohol Abuse and Acute Lung Injury: Epidemiology and Pathophysiology of a Recently Recognized Association

Assessment of anatomic relation between pulmonary perfusion and morphology in pulmonary emphysema with breath-hold SPECT-CT fusion images

Mitochondrial Injuries in Rat Lungs Preserved for 17 h: An Ultrastructural Study

Contact Info

Product

Resources

About