Protective Effects of Vitamin C Against Cisplatin-Induced Nephrotoxicity and Lipid Peroxidation in Adult Rats: A Dose-Dependent Study

Antunes, Lusânia Maria Greggi; Darin, Joana D’Árc Castania; Bianchi, María de Lourdes Pires

doi:10.1006/phrs.1999.0600

Cited by 193 publications

(71 citation statements)

References 31 publications

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“…Solving the most safe and effective known heart disease, it consists of daily administration of a dose of 6000 to 10,000 mg vitamin C (Abdul-Razzak et al, 2012;Abou-Zeid, 2014;Ahmed et al, 2011;Ajith et al, 2007;Antunes et al, 2000;Atasayar et al, 2009;Babaev et al, 2010;2011;Barja et al, 1994).…”

Section: Clinical Studies Showmentioning

confidence: 99%

We are Addicted to Vitamins C and E-A Review

Aversa¹,

Petrescu²,

Apicella³

et al. 2016

American Journal of Engineering and Applied Sciences

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A Canadian researchers team led by dr. GC Willis, found that heart diseases are caused by hidden forms of scurvy and chronic and can be cured with high doses of vitamin C without heart surgery and drug treatments costly and with effects devastating side in organic plan. But the process of healing cardiovascular disease with vitamin C is not approved by the medical institutions and the pharmaceutical industry, which earns billions of dollars in surgeries and drugs that are used in allopathic therapies for various cardiac diseases. Canadian scientist discovery was confirmed in the late 80 s by Dr. Linus Pauling, Nobel laureate, the most noted human of his time. The medical care developed by Dr. Pauling include vitamin C with added lysine (amino acid nutritional qualities, existing in most plant and animal proteins) and it works cleanly, healing cardiopathy once thought were incurable. Dr. Pauling medical care records healing miracles coronary diseases. It had been identified back then that vitamin C deficiency within the body weakens human arteries by forming induration of the arteries plaques (infiltration of the walls of the artery and arteries with fat), that blocks blood circulation. This paper aims to spotlight the importance of vitamin C for the treatment and prevention of circulatory diseases especially. The daily minimum demand of vitamin C at tissues and cells level for a healthy person is: 75 mg/day women, 90 mg/day for men, 100 mg/day smokers. But always need a bigger tank because these amounts could reach all tissues and cells of a healthy organism: about 500-1000 mg/day. When the body is disturbed or ill, quantities required to repair cells, are much higher 5000-10000 mg/day.

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Section: Clinical Studies Showmentioning

confidence: 99%

We are Addicted to Vitamins C and E-A Review

Aversa¹,

Petrescu²,

Apicella³

et al. 2016

American Journal of Engineering and Applied Sciences

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“…Previous reports indicated that AA had a dose-dependent protective effect against nephrotoxicity 23 . In conjunction with this data, we observed that PCO was decreased in Group III that received high-dose AA; while PCO level was not decreased in Groups I and II after the procedure.…”

mentioning

confidence: 92%

An experimental study of ascorbic acid effects in acute renal failure under general anesthesia

et al. 2017

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Purpose: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. Methods: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects were allocated into 3 groups: Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) and high (300 mg/kg) doses of AA in addition to sevoflurane, respectively. Rhabdomyolysis and myohemoglobinuric ARF was formed by intramuscular administration of glycerol on the upper hind limb on the 15 th minute of inhalation anesthesia. Biochemical parameters consisted of serum levels of blood urea nitrogen, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), total antioxidant capacity (TAC), and protein carbonyl content. Histopathological variables were tubular necrosis, fibrin, and cast formation. Results: NGAL levels were significantly lower in Group III than Group II and Group I. On the other hand, TAC, PCO, urea and creatinine levels were notably higher in Group I compared with Groups II and III. There was a significant difference between 3 groups on frequencies of acute tubular necrosis (p=0.003), fibrin (p<0.001) and cast (p<0.001). Acute tubular necrosis and fibrin formation were more prominent in Group I. Casts were more common in Groups II and III. Conclusions: The ascorbic acid serve as a prophylactic agent against renal damage in patients receiving sevoflurane anesthesia and higher doses were associated with more apparent protective effects.

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“…Although some preclini-cal data show that antioxidants might reduce the effectiveness of chemotherapy [16], other studies report similar or better response in chemotherapy when combined to antioxidant-rich diet [17][18][19]. For example, while an excess in vitamin C is believed to facilitate glucose transportation into cancer cells, thus inducing proliferation [20][21][22], antioxidant vitamins such as C and E have been successfully used as supplements for ameliorating the side effects of chemotherapy [23,24]. In general, if generation of reactive oxygen species by a cancer chemotherapeutic agent plays a role in its cytotoxicity, antioxidants may interfere with the drug's antineoplastic activity.…”

Section: Introductionmentioning

confidence: 99%

Cortisol levels and serum antioxidant status following chemotherapy

Limberaki¹,

Eleftheriou²,

Gasparis³

et al. 2011

Health

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Chemotherapy results in increased free radical formation and depletion of tissue antioxidants. Moreover, patients receiving chemotherapy are under emotional stress, which is also accompanied by low antioxidant levels. In the present study, we measured cortisol, the main stress hormone, and total antioxidant capacity (TAC) in serum of 51 cancer patients during chemotherapy. Antioxidant activity was estimated by measuring the influence of serum in oxidation of ABTS (2,2΄-azino-bis (3-ethylbenz-thiazoline-6-sulfonic acid to ABTS+ by methmyoglobin (Antioxidant kit of Cayman). Serum cortisol was measured using an ELISA colorimetric assay. Serum TAC was significantly decreased (75% decrease compared to normal levels, p = 0.001) in all patients during chemotherapy, while blood cortisol concentration was increased by 10%, (p = 0.044). Lower antioxidant levels and higher cortisol concentration were detected in patients receiving chemotherapeutic drugs daily, compared to the ones receiving chemotherapy once a week. A difference between sexes was observed with male patients presenting lower antioxidant status and higher cortisol levels than females. A significant and persistent decrease in antioxidant capacity accompanied by increased cortisol concentration was observed in all patients during chemotherapy. This fact, which is probably generated by biological and emotional stress, increases the probability of harmful side effects and organism weakening and needs to be considered during patients' treatment.

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Protective Effects of Vitamin C Against Cisplatin-Induced Nephrotoxicity and Lipid Peroxidation in Adult Rats: A Dose-Dependent Study

Cited by 193 publications

References 31 publications

We are Addicted to Vitamins C and E-A Review

We are Addicted to Vitamins C and E-A Review

An experimental study of ascorbic acid effects in acute renal failure under general anesthesia

Cortisol levels and serum antioxidant status following chemotherapy

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