Abstract:Objective
Undenatured Type II Collagen (Lonza's UC‐II® branded ingredient, Lonza) shows an ability to reduce inflammation of rheumatoid arthritis (RA) and osteoarthritis through oral tolerance, but the mechanisms underlying this protective effect remain unclear. Our goal is to understand how changes in the gut microenvironment affect tolerogenic responses upon oral administration of UC‐II® supplementation.
Hypothesis
We hypothesize that systemic inflammation during inflammatory arthritis regulate local tolerog… Show more
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