Protective effects of Turkish propolis on alcohol-induced serum lipid changes and liver injury in male rats

Kolankaya, Dürdane; Selmanoğlu, Güldeniz; Sorkun, Kadriye; Salih, Bekir

doi:10.1016/s0308-8146(01)00400-9

Cited by 114 publications

(88 citation statements)

References 7 publications

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“…It is also used in folk medicine due to its hepatoprotective activity; however, little is known about its mechanisms of action (Kolankaya et al, 2012). The knowledge of phytochemicals molecular mechanisms became a good strategy in the search for new anti-inflammatory compounds.…”

Section: Introductionmentioning

confidence: 99%

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Búfalo

Ferreira

Costa

et al. 2013

Journal of Ethnopharmacology

153

102

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Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages, Journal of Ethnopharmacology, http://dx.doi.org/ 10. 1016/j.jep.2013.06.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractEthnopharmacological relevance: Propolis is a bee product with numerous biological and pharmacological properties, such as immunomodulatory and anti-inflammatory activities.It has been used in folk medicine as a healthy drink and in food to improve health and prevent inflammatory diseases. However, little is known about its mechanism of action.Thus, the goal of this study was to verify the antioxidant activity and to explore the antiinflammatory properties of propolis by addressing its intracellular mechanism of action.Caffeic acid was investigated as a possible compound responsible for propolis action. Materials and Methods:The antioxidant properties of propolis and caffeic acid were evaluated by using the 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging method. To analyze the anti-inflammatory activity, Raw 264.7 macrophages were treated with different concentrations of propolis or caffeic acid, and nitric oxide (NO) production, a strong pro-inflammatory mediator, was evaluated by the Griess reaction. The concentrations of propolis and caffeic acid that inhibited NO production were evaluated on intracellular signaling pathways triggered during inflammation, namely p38 mitogenactivated protein kinase (MAPK), c-jun NH 2 -terminal kinase (JNK1/2), the transcription nuclear factor (NF)-NB and extracellular signal-regulated kinase (ERK1/2), through Western blot using specific antibodies. A possible effect of propolis on the cytotoxicity of hepatocytes was also evaluated, since this product can be used in human diets.Results: Caffeic acid showed a higher antioxidant activity than propolis extract. Propolis and caffeic acid inhibited NO production in macrophages, at concentrations without cytotoxicity. Furthermore, both propolis and caffeic acid suppressed LPS-induced signaling pathways, namely p38 MAPK, JNK1/2 and NF-NB. ERK1/2 was not affected by propolis extract and caffeic acid. In addition, propolis and caffeic acid did not induce hepatotoxicity at concentrations with strong anti-inflammatory potential. Conclusions:Propolis exerted an antioxidant and anti-inflammatory action and caffeic acid may be involved in its inhibitory effects on NO production and intracellular signaling cascades, suggesting its use as a natural source of safe anti-inflammatory drugs.

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Section: Introductionmentioning

confidence: 99%

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Búfalo

Ferreira

Costa

et al. 2013

Journal of Ethnopharmacology

153

102

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“…The propolis mechanism of action against mercury toxicity is not fully known, but it is believed that it can increase the elimination of heavy metals from the tissues through its antioxidant activity and metal chelating ability (5,7,10,21). Due to the presence of flavonoids and phenolic compounds, which are powerful free radical scavengers, propolis protects the cell membrane from lipid peroxidation (12,21). Propolis is widely used in human medicine because of its antimicrobial, antiviral, antifungal, immunostimulating and antioxidant activity, but little is known about its influence on wild birds.…”

Section: Resultsmentioning

confidence: 99%

“…As a natural compound of a bee's derivate product, propolis is a common name for a complex of various plant exudates mixture that contains a broad spectrum of biologically active compounds collected by honey bees (10,12). It is mainly used in construction, adaptation and protection of bee hives (5,7).…”

mentioning

confidence: 99%

Influence of the administration of propolis and bee pollen preparation on the concentration of mercury in the muscles, kidneys and liver of white storks

Piedra¹,

Zienkiewicz²,

Khudhur³

et al. 2018

Medycyna Weterynaryjna

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A total of ninety white storks (Ciconia ciconia) of both sexes aged over one year of life and at a body weight between 2.8 – 4.15kg were subjects for observations. They were collected from the Warmia and Masuria region, and were rehabilitees of The Wild Birds Rehabilitation Center (Bukwald, Poland). The storks formed a group of birds that had wing damage like broken bones and were unable to fly. According to the severity of the case storks underwent three different kinds of treatment. Light cases of motion disability were submitted to wing or leg stabilization with adhesive bandages (treatment I), while middle and severe cases were additionally submitted to the administration of one (treatment II) or two capsules (treatment III) of propolis and pollen bee preparation (Apipol Farma’s Propolis Plus®) for two weeks, respectively. After the convalescence period a total of twenty three white storks did not recover and were euthanized and dissected. Post mortem samples of pectoral and femoral muscles as well as liver and kidney samples were taken. Mercury concentration was analyzed and the results revealed that the level in the kidneys and liver of white storks not receiving propolis preparation were significantly higher than that of those from treatment II and III. Contrary to this, the mercury concentration recorded in the pectoral and femoral muscles of the birds of treatment II and treatment III were significantly higher than that of the treatment without propolis preparation. The results showed that propolis and pollen bee preparation can reduce the level of mercury in kidneys and liver, but has no influence on the reduction of mercury in pectoral and femoral muscles. .

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“…The chemical content of Turkish propolis was investigated with the focus on protective effect against alcohol-induced oxidative stress (Kolankaya et al, 2002). The authors declared that the ethanolic propolis extract of propolis, at dose of 200 mg/kg body weight/day, was given, by gavage, to male rats for 15 days.…”

Section: The Effects Of Propolis Supplementation In Animals 321 Antmentioning

confidence: 99%

“…No toxic effects of Turkish propolis were found, while it caused an increase in HDL level and a decrease in LDL level. They suggest that these effects are protective against degenerative diseases and against alcohol-induced oxidative stress via free radicals (Kolankaya et al, 2002).…”

Section: The Effects Of Propolis Supplementation In Animals 321 Antmentioning

confidence: 99%

The Effects of Propolis in Animals Exposed Oxidative Stress

Seven¹,

Yılmaz²,

Seven³

et al. 2012

Oxidative Stress - Environmental Induction and Dietary Antioxidants

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Protective effects of Turkish propolis on alcohol-induced serum lipid changes and liver injury in male rats

Cited by 114 publications

References 7 publications

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Influence of the administration of propolis and bee pollen preparation on the concentration of mercury in the muscles, kidneys and liver of white storks

The Effects of Propolis in Animals Exposed Oxidative Stress

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