Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice

Mansour, Mahmoud A.

doi:10.1016/s0024-3205(00)00592-0

Cited by 155 publications

(94 citation statements)

References 28 publications

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“…Our results on SVP toxicity are compatible with studies demonstrating amelioration by pretreatment with free radical traps [36] or antioxidants [37]. Reports in the literature are suggestive that the ameliorative effect of TQ versus CCl 4 -induced hepatotoxicity is mediated through decreased hepatic lipid peroxidation [15,39]. Nagi and colleagues [17] evaluated TQ as an inhibitor of lipid peroxidation using liver homogenate as the source of lipid, and ferric ascorbate to induce lipid peroxidation.…”

Section: Discussionsupporting

confidence: 87%

Beneficial Interaction of Thymoquinone and Sodium Valproate in Experimental Models of Epilepsy: Reduction in Hepatotoxicity of Valproate

et al. 2006

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The antiepileptic potential of thymoquinone (TQ) was studied in mice by using pentylenetetrazole (PTZ) and maximal electroshock seizure (MES)-induced convulsion models. In this investigation, the combined treatment of TQ and sodium valproate (SVP) was also studied. The aim of this part was to minimize SVPinduced hepatotoxic implications, by reducing its antiepileptic dose. TQ in both PTZ-and MES-models increased SVP potency. The experiments dealing with the effects of TQ on the ED 50 of SVP revealed that TQ reduced the ED 50 of SVP in both the models. However, this potentiation of SVP antiepileptic response was relatively more significant in PTZ model at both 50 and 100 mg/kg doses of TQ. Although very well tolerated and effective, SVP is well known for its hapatotoxic implications. In the experiment dealing with subacute treatment, SVP (1300-1500mg/kg/day in drinking water) for 21 days, produced hepatotoxicity in mice, characterized by elevated serum ALT and AST, reduced levels of non protein sulfhydryls and increase in lipid peroxidation in hepatic cells. Hepato-protection was successfully achieved when TQ (5-5.5mg/kg/day) was combined with SVP in drinking water for the same duration. The protective activity of TQ was evident by averting any serum ALT rise seen in SVP treatment. Though there is no prevention to the rise in lipid peroxidation in hepatic tissue but the same time a significant recovery in glutathione was evident by TQ joint treatment.However, a combination of TQ and low dose of SVP may be useful strategy to minimize adverse reactions of SVP. From the results of the present study that disclosed a protective role of TQ against SVP toxic damage to the liver, it could be harmful effects. It also protected against the liver enzyme induction seen in the case of SVP alone. KeywordsThymoquinone, valproate, potentiation, maximal electroshock convulsions, hepatoprotection.Abbreviations: maximal electroshock seizure = MES; pentylenetetrazole = PTZ; thymoquinone = TQ; sodium valproate = SVP; malondialdehyde = MDA; nonprotein sulfhydryl groups = NPSH; glutathione = G-SH.

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Section: Discussionsupporting

confidence: 87%

Beneficial Interaction of Thymoquinone and Sodium Valproate in Experimental Models of Epilepsy: Reduction in Hepatotoxicity of Valproate

et al. 2006

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“…N. sativa plant is one of the most extensively studied, both phytochemically and pharmacologically. The extracts of N. sativa seeds have been used by patients to suppress coughs disintegrate renal calculi, retard the carcinogenic process (Worthen et al, 1998;Hosseinzadeh et al, 2007) treat abdominal pain, diarrhea, flatulence and polio (Enomoto et al, 2001), exert choleretic and uricosuric activities, antiinflammatory (Chakravarty, 1993;Houghton et al, 1995) and antioxidant effects (Mansour et al, 2002;Mansour, 2000). Besides, the essential oil was shown to have antihelminthic (Agarwal et al, 1979), antinematodal (Akhtar and Riffat, 1991), antischistosomal (Mahmoud et al, 2002), antimicrobial (Aboul-Ela et al, 1996;Hanafy and Hatem, 1991;Aboul-Ela, 2002) and antiviral (Salem and Hossain, 2000) effects.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles

Al-Haj¹,

Shamsudin²,

Alipiah³

et al. 2010

American Journal of Pharmacology and Toxicology

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Problem statement: Seeds of Nigella sativa L., commonly known as black seed, have been used in traditional medicine by many Asian, Middle Eastern and Far Eastern Countries to treat headache, coughs, abdominal pain, diarrhea, asthma, rheumatism and other diseases. The seeds of this plant are the most extensively studied, both phytochemically and pharmacologically. The aqueous and oil extracts of the seeds have been shown to possess especially nowadays in pharmaceutical antioxidant, anti-inflammatory, anticancer, analgesic, antimicrobial activities and medicinal and cosmetic applications, sanitary, cosmetic, agricultural and food industries. Approach: The aim of this study was to formulate a new delivery system for dermal and cosmetic application by the incorporation of Nigella sativa essential oil into solid lipid nanoparticles SLN. SLN formulations were prepared following the high-pressure homogenization after starring and ultra-trax homognization techniques using hydrogenated palm oil Softisan 154 and N. sativa essential oil as lipid matrix, sorbitol and water as surfactants. The SLN formulation particle size was determined using Photon Correlation System (PCS). Results: The change of particle charge was studied by Zeta Potential (ZP) measurements, while the melting and re-crystallization behavior was studied using Differential Scanning Calorimetry (DSC). Data showed a high physical stability for both formulations at various storage temperatures during 3 months of storage. In particular, average diameter of N. sativa essential oilloaded SLN did not vary during storage and increased slightly after freeze-drying the SLN dispersions. Conclusion: Therefore, obtained results showed that the studied SLN formulations are suitable carriers in pharmaceutical and cosmetic fields.

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“…MDA, a decomposition product of lipid hydroperoxides (Gutteridge, 1995) is widely used as marker of lipid peroxidation (Mansour, 2000), its elevated level could reflect the degree of lipid peroxidation injury in hepatocytes (Hu et al, 2001). In this study, MDA levels in the supernatant of CCl 4 treated hepatocytes were significantly elevated, pre-treatment or pre and posttreatment of the hepatocytes with SCE (200 and 400 µg ml Antioxidant property is claimed to be one of the mechanisms of hepatoprotective drugs (Recknagel, 1967).…”

Section: Discussionmentioning

confidence: 99%

In vitro protective effect of Schisandra chinensis extract against carbon tetrachlorideinduced hepatotoxicity in common carp (Cyprinus carpio)

Yin¹,

Wang²,

Cao³

et al. 2013

Afr. J. Pharm. Pharmacol.

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Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice

Cited by 155 publications

References 28 publications

Beneficial Interaction of Thymoquinone and Sodium Valproate in Experimental Models of Epilepsy: Reduction in Hepatotoxicity of Valproate

Beneficial Interaction of Thymoquinone and Sodium Valproate in Experimental Models of Epilepsy: Reduction in Hepatotoxicity of Valproate

Characterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles

In vitro protective effect of Schisandra chinensis extract against carbon tetrachlorideinduced hepatotoxicity in common carp (Cyprinus carpio)

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