Protective effects of thymoquinone against acrylamide-induced liver, kidney and brain oxidative damage in rats

Exploring the Potential of Therapeutic Agents Targeted towards Mitigating the Events Associated with Amyloid-β Cascade in Alzheimer’s Disease

“…The first investigational evidence was provided in 2010, when a β-secretase inhibitor, GRL-8234, was employed to treat Tg2576 transgenic mice, and resulted in improved cognitive effects [ 54 ]. Moreover, soluble Aβ levels were also found to be retarded in mice [ 55 , 56 ] following GRL-8234 administration [ 54 ]. A significant reduction in Aβ plaque load was also observed in aged mice treated with GRL-8234 [ 57 ].…”

Sub-chronic toxicity of ethanol leaf extract of Syzygium guineense on the biochemical parameters and histopathology of liver and kidney in the rats

“…Plant products have potent protective effects against toxic insults [ [20] , [21] , [22] ]. However, several researchers have shown that many medicinal plants have potential toxicity on cellular and biochemical parameters of blood [ 23 , 24 ] and histopathology of various internal organs like the liver and kidney [ [25] , [26] , [27] , [28] , [29] ].…”

The Effect of Taxifolin on Acrylamide-induced Oxidative and Proinflammatory Brain Injury in Rats: A Biochemical and Histopathological Study

“…4 Recent studies showed that acrylamide caused oxidative brain damage by increasing Malondialdehyde (MDA) production in the brain tissue and reducing endogenous glutathione (GSH) concentrations as well as activities of antioxidant enzymes. [5][6][7][8] Moreover, it has been demonstrated that acrylamide produced neurotoxic effects by increasing the production of both oxidants and proinflammatory cytokines such as interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). [6][7][8][9] These literature data suggest that antioxidant and anti-inflammatory drugs can be useful in the treatment of the neurotoxicity of acrylamide.…”