Protective effects of three extracts from Antarctic plants against ultraviolet radiation in several biological models

Pereira, Betina Kappel; Rosa, Renato Moreira; Silva, Juliana da; Guecheva, Temenouga Nikolova; Oliveira, Iuri Marques de; Ianistcki, Martus; Benvegnú, Vinícius Cosmos; Furtado, Gabriel Vasata; Ferraz, Alexandre de Barros Falcão; Richter, Marc François; Schröder, Nádia Teresinha; Pereira, Antônio Batista; Henriques, João Antônio Pêgas

doi:10.1016/j.jphotobiol.2009.04.011

Cited by 47 publications

(31 citation statements)

References 67 publications

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“…However, inhibitory activity against in vitro (proteolytic and coagulating) or in vivo (hemorrhagic, edematogenic, and lethality) activities of B. jararacussu venom is being presented for the first time. in such unfavorable biotic and abiotic conditions, they synthesize a variety of molecules with different biological and pharmacological properties (Pattanaik et al 2008;Pereira et al 2009), but an antivenom effect has not been described before. The proteolytic, coagulant, and hemorrhagic activities of venoms are caused by proteases, called serine protease and metalloproteinases.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that organisms that live in polar regions are subjected to extreme and harsher abiotic and atmosphere conditions (low temperatures and humidity, frequent and rapid fluctuations from freezing to thawing, severe winds, and long periods of light and darkness), and as consequence, they develop natural strategies to face such aggressive conditions, allowing them to survive under these most unfavorable environment. One of these strategies is the production of photoprotective molecules such as mycosporine-like amino acids (MMAs), scytonemim secreted by cyanobacteria and flavonoids secreted by plants (Pereira et al 2009). MAAs are the strongest UVR-absorbing compounds in nature (Pattanaik et al 2008;Carreto and Carignan 2011), and a molecule (called Prasiolin) with such activity has been isolated from Prasiola calophylla and its chemical structure elucidated (Hartmann et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…MAAs are the strongest UVR-absorbing compounds in nature (Pattanaik et al 2008;Carreto and Carignan 2011), and a molecule (called Prasiolin) with such activity has been isolated from Prasiola calophylla and its chemical structure elucidated (Hartmann et al 2016). The adhesive property of the genus Prasiola has been described before, demonstrating a potential biotechnological application (Pereira et al 2009), but no study related to the biological or pharmacological effects of P. crispa has been performed previously.…”

Section: Introductionmentioning

confidence: 99%

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The seaweed Prasiola crispa (Chlorophyta) neutralizes toxic effects of Bothrops jararacussu snake venom

et al. 2016

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In Brazil, the snake genus Bothrops has many venomous species with 90 % of cases of accidents. Snake bites by Bothrops jararacussu result in moderate to severe envenoming, characterized by hemorrhage, coagulation disorders, tissue necrosis, and death. Antivenom has been regularly used for more than a century but poorly neutralizes myonecrosis. And, as a consequence, victims may have their affected limbs amputated. Thus, the production of antivenom must be improved as well as alternative treatments investigated. Thus, the ability of four extracts of the green alga Prasiola crispa to neutralize some toxic effects of B. jararacussu venom was tested. P. crispa was collected in Antarctica, then extracted using four solvents, dichloromethane (DCM), ethyl acetate (ETA), n-hexane (HEX), or methanol (MET). The extracts were incubated with B. jararacussu venom, and in vivo (hemorrhagic, lethal, and edematogenic) or in vitro (coagulating and proteolytic) activities were performed. Moreover, B. jararacussu venom was injected into mice before or after the injection of alga extracts. Overall, extracts inhibited all activities. The MET extract inhibited less and HEX, DCM and ETA inhibited more efficiently the activities. These latter extracts fully protected mice from B. jararacussu-induced hemorrhage and delayed death of mice. Edema was partially inhibited (20 %) by all extracts. Neutralization of hemorrhage was also observed when the extracts of P. crispa were administered after or before the venom injection. These results indicate that the extracts of P. crispa have potential to treat or to prevent some toxic effects of B. jararacussu venom, thus aiding in the antivenom therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The seaweed Prasiola crispa (Chlorophyta) neutralizes toxic effects of Bothrops jararacussu snake venom

et al. 2016

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“…(Mostaert et al, 2006), highlighting the biotechnological importance of this organism. Other studies carried out with other Antarctic plant species, have demonstrated low toxic e ects for mammalian and non-mammalian cells, associated with protective e ects against UV-induced damage (Pereira et al, 2009).…”

Section: Introductionmentioning

confidence: 95%

“…is fact has lead to the developing of natural strategies that enable these organisms to survive under the most extreme environmental conditions on Earth. Among these adaptation strategies is the production of photoprotective compounds, such as mycosporine-like amino acids, scytonemim secreted by cyanobacteria and flavonoids secreted by plants (Pereira et al, 2009). is fact emphasizes the importance of studies concerning the biological e ects of these organisms, which may present in its constitution a http://dx.doi.org/10.4322/apa.2014.097 combination of chemical compounds normally not found in other organisms.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Prasiola Crispa Extract Fractions in the Adult Fruit Fly Drosophila Melanogaster: An Update

Zemolin¹,

Nunes²,

Rodrigues³

et al. 2013

INCT-APA

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The flavonoid 3′‐hydroxylase gene from the Antarctic moss Pohlia nutans is involved in regulating oxidative and salt stress tolerance

Liu

Wang

et al. 2021

Biotech and App Biochem

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Flavonoids are the important secondary metabolites. They are thought to play an important role in plant adaptation to terrestrial environment. However, the downstream branching pathway of flavonoids in bryophytes, which are the most ancient of terrestrial plants, remains unclear. Here, we cloned a flavonoid 3′hydroxylase gene (PnF3′H) from the Antarctic moss Pohlia nutans and studied its function in plant stress tolerance. The Arabidopsis with overexpressing PnF3′H (AtOE) were constructed. The AtOE plants had more lateral roots and higher activities of antioxidant enzymes than the wild-type plants under oxidative stress. Meanwhile, the gene expression levels of reactive oxygen species (ROS) scavengers (i.e., AtCAT3, AtFeSOD1, and AtCu-ZnSOD3) were upregulated in the AtOE plants, and the transcription levels of ROS producing enzyme genes were significantly downregulated. The AtOE plans showed increased sensitivity to NaCl stress or abscisic acid (ABA) treatment during seed germination and early root development. Furthermore, several stress-resistant genes in the ABA signaling pathway were also downregulated in the AtOE plants when compared with the wild-type plants. These results suggested that PnF3′H participates in regulating the oxidative tolerance and ABA sensitivity to enable P. nutans to adapt to polar environments.

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Protective effects of three extracts from Antarctic plants against ultraviolet radiation in several biological models

Cited by 47 publications

References 67 publications

The seaweed Prasiola crispa (Chlorophyta) neutralizes toxic effects of Bothrops jararacussu snake venom

The seaweed Prasiola crispa (Chlorophyta) neutralizes toxic effects of Bothrops jararacussu snake venom

Toxicity of Prasiola Crispa Extract Fractions in the Adult Fruit Fly Drosophila Melanogaster: An Update

The flavonoid 3′‐hydroxylase gene from the Antarctic moss Pohlia nutans is involved in regulating oxidative and salt stress tolerance

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