Protective effects of taurine against alloxan-induced diabetic cataracts and refraction changes in New Zealand White rabbits

Hsu, Yu‐Wen; Yeh, Shang-Min; Chen, Ya-Yu; Chen, Yi‐Chen; Lin, Shiun-Long; Tseng, Jung-Kai

doi:10.1016/j.exer.2012.08.001

Cited by 11 publications

(6 citation statements)

References 34 publications

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“…In our results methyltetrahydrofolic acid was also found negatively correlated with plasma glucose level. Taurine may protect the lens proteins against glycation and was found preventive against alloxan‐induced diabetic cataracts in an animal model . Xanthine and uric acid are metabolites regulated by xanthine oxidoreductase enzymes which catalyse the oxidation of hypoxanthine to xanthine and xanthine to uric acid, and the reduction of NAD+ or molecular oxygen .…”

Section: Resultsmentioning

confidence: 99%

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

et al. 2018

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Cataract is the leading cause of blindness worldwide. Epidemiological studies revealed up to a fivefold increased prevalence of cataracts in diabetic subjects. Metabolomics is nowadays frequently implemented to understand pathophysiological processes responsible for disease occurrence and progression. It has also been used recently to study the metabolic composition of aqueous humor (AH). AH is a transparent fluid which fills the anterior and posterior chambers of the eye. It supplies nutrients and removes metabolic waste from avascular tissues in the eye. The aim of this study was to use metabolomics to compare the AH of diabetic and non-diabetic patients undergoing cataract surgery. Several antioxidants (methyltetrahydrofolic acid, taurine, niacinamide, xanthine, and uric acid) were found decreased (-22 to -61%, p-value 0.05-0.003) in AH of diabetics. Also amino acids (AA) and derivatives were found decreased (-21 to -36%, p-value 0.05-0.01) while glycosylated AA increased (+75-98%, p-value 0.03-0.009) in this group of patients. Metformin was detected in AH of people taking this drug. To our knowledge, this is the first metabolomics study aiming to assess differences in AH composition between diabetic and non-diabetic patients with cataract. An increased oxidative stress and perturbations in amino acid metabolism in AH may be responsible for earlier cataract onset in diabetic patients.

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Section: Resultsmentioning

confidence: 99%

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

et al. 2018

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“…Nuclear sclerosis (increased compaction of inner cortical lens fibers) was noted only in older animals (average age 6.0 +/-2.9 years in one series 222 and 3.5-4.0 years in another series) 318 . Lens fiber degeneration and more extensive lesions can develop as sequelae of many non-heritable spontaneous or experimentally induced conditions that secondarily affect the lens (i.e., diabetes, glaucoma, posterior synechia, and proliferative vitreoretinopathy) 24,248,300,[319][320][321] . Many cases of spontaneous lenticular opacities in rabbits are suspected to be of heritable (genetic) origin 314,315 .…”

Section: H Anatomy Of the Lensmentioning

confidence: 99%

“…Experimentally induced lens fiber degeneration in rabbits occurs with administration of various chemical test articles; exposure to microwaves, UVA radiation, or electric current; hyperoxia; and dietary imbalances 220,294,320,321,[323][324][325] . Lens fiber degeneration in rabbits in toxicity studies can also result from extraneous physical trauma to the lens (i.e., from misplaced hypodermic needles during intravitreal injections or from cage accidents or other misadventure).…”

Section: H Anatomy Of the Lensmentioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

et al. 2021

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand. asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the laboratory rabbit used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

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“…In this study, taurine appeared to protect the lens against the development of sugar-induced cataracts and may have exerted this effect by decreasing oxidative damage (Malone et al, 1993;Rathore and Gupta, 2010). The role of taurine deficiency in cataract development has been studied by a number of other groups (Zhang and Chen, 1998;Son et al, 2007;Hsu et al, 2012). It is possible that the deficiency of taurine in the cubs receiving the two different artificial milk formulas may have exposed their lenses to an oxidative effect.…”

Section: Milk and Serum Analyses Resultsmentioning

confidence: 99%

Cataracts and strabismus associated with hand rearing using artificial milk formulas in Bengal tiger (<i>Panthera tigris spp tigris</i>) cubs

Lange¹,

Lima²,

Frühvald³

et al. 2017

Open Vet J.

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The aim of this investigation is to describe the potential contributing nutritional factors involved in the development of ophthalmic and dermatologic changes in four Bengal tiger (Panthera tigris spp tigris) cubs fed an artificial milk formula. The affected animals were compared with two other tiger cubs that had been nursed by their dam naturally. After the first clinical signs appeared, the tiger cubs underwent ophthalmic evaluation. Severe symmetric generalized alopecia over the trunk, sparing the head and distal portion of the front and rear limbs, bilateral cataracts and strabismus were noticed. Milk and blood from the mother, as well as blood from the healthy and affected cubs were collected in order to evaluate complete blood counts, serum chemistry values, and amino acid levels. The amino acid concentrations in the artificial formula were also evaluated for comparison to the milk from the dam. The concentration of taurine, arginine, phenylalanine, tryptophan and histidine were very low in the artificial formulas as compared to the dam´s milk. The tiger cubs that received the artificial formula had lower levels of the amino acids listed previously as compared to those that nursed from the dam naturally. Taurine, as well as arginine, phenylalanine, tryptophan and histidine deficiency appeared to be possible causes of the development of skin problems, cataracts and strabismus in the tiger cubs fed with these particular artificial milk replacers. In the future, special attention should be given in order to make sure that adequate levels of these amino acids are present in artificial milk for tiger cubs.

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Protective effects of taurine against alloxan-induced diabetic cataracts and refraction changes in New Zealand White rabbits

Cited by 11 publications

References 34 publications

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

Cataracts and strabismus associated with hand rearing using artificial milk formulas in Bengal tiger (<i>Panthera tigris spp tigris</i>) cubs

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