Protective effects of Syzygium aromaticum oil (Clove) against acrylamide induced hepatic, renal, and testicular toxicity in rats

Abstract

<jats:p>This study aimed to investigate the possible protective role of clove oil against acrylamide induced oxidative damage and impairment of liver, kidney, and testicular functions in albino rats. The apparent oxidative damage was associated with evident hepatic, renal, and testicular dysfunction, which was confirmed in histopathological lesions, and increased serum aspartate aminotransferase and alanine aminotransferase activities. Acrylamide decreased serum total protein and albumin contents; increased urea and creatinine contents. Acrylamide also reduced testosterone concentration. Treatment of acrylamide intoxicated rats with clove oil minimized liver, kidney, and testicular histopathological changes and normalized their functions. Our findings demonstrate that acrylamide is not only associated with hepatotoxicity but also nephrotoxicity and testicular toxicity. Clove oil administration provided substantial organ protection against hepatic, renal, and testicular dysfunction induced by acrylamide, which was possibly mediated through their antioxidant activities. </jats:p>

Glycemic profile, inflammatory markers, biochemical and histopathological parameters of mice fed with fermented dairy beverage with clove essential oil

“…When evaluating ALT, AST and Albumin (Figure 2C) we obtain a result similar to that obtained by (Elkomy et al, 2018) in which rats treated with 200mg/kg of body weight with clove essential oil, also showed no significant difference (p <0.05), in these biochemical parameters. In the context of toxicity, ALT and AST are released and increase in plasma three times more than the baseline level (Xu et al, 2015) The biochemical analysis of triglycerides, total cholesterol and HDL, in the group FDB+CEO did not differ significantly (p <0.05), in the Ctrl and FDB groups (Fig.…”

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

“…Protective role against acrylamide induced oxidative damage and impairment of liver, kidney, and testicular functions in albino rats 100 and 200 mg/kg of body weight for 21 consecutive days [152] Trigonella foenum-graecum L.…”

Protective role of thymoquinone against acrylamide-induced nephrotoxicity in rats

“…Moreover, ACR and its metabolite, glycidaimde, are considered carcinogenic agents that affect different organs in the body as, the liver, kidney, brain, lungs, and intestine (Capuano and Fogliano, 2011;Bin-Jumah et al, 2021). Hepatotoxicity, nephrotoxicity, and neurotoxicity induced by ACR were described in several reports (Yousef and El-Demerdash, 2006;Zhu et al, 2008;Aboubakr et al, 2018;Elkomy et al, 2018). The main mechanism of action is the induced ACR oxidative stress and lipid peroxidation as reported by several studies (Abdel-Daim et al, 2020; Elhelaly et al, 2019).…”