Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress

Ameliorative effect of betulinic acid on oxidative damage and apoptosis in the splenocytes of dexamethasone treated mice

“…The results indicated that BA had significantly decreased the impaired mitochondria induced by Dex. Activation of caspase-9 and 3 in several cell systems as a consequence of mitochondrial membrane depolarization has been reported by several groups [20,21]. The caspase-3 activity of splenocytes were increased almost 1.62-fold in Dex Group II compared to the Group I (Fig.…”

“…Oxidative stress, defined as imbalance between the production of prooxidants and antioxidant defenses in the organism, is a key phenomenon in autoimmune diseases or chronic inflammation [21]. ROS, as predominant prooxidants, are tightly regulated to provide beneficial physiological effects; however, excessive ROS formation can be an important mediator of damage to cell structures and attacks cellular biomolecules such as lipid, protein and DNA which may disrupt membrane integrity and cellular function, thereby leading to cell death [22,23].…”

Effect of DriedCitrus SinensisPeel on Gastrointestinal Microbiota and Immune System Traits of Broiler Chickens

“…Dried Citrus sinensis peel (DCSP) can significantly improve the immune system activities, and this action has been attributed to their antioxidant properties (Chen et al, 2012). Moreover, it has been demonstrated that herbal extracts can increase the antibody production, especially immunoglobulin G (IgG), indirectly improving the immune system activity with their anti-virus and anti-bacteria action (Catala-Gregori et al, 2007).…”

Kinetics of Hesperetin for Liver Fortification in γ-Irradiated Mice

“…Kaneto et al (2001) showed that antioxidants could have beneficial effects on pancreatic-cells by neutralizing the oxidative stress. Hesperetin displayed a significant cytoprotective effect against oxidative stress (Chen et al, 2012). Accordingly, in the current study, the potent antioxidant, hesperetin has been found to preserve the pancreatic-cell functions and maintain the level of blood glucose and liver glycogen.…”