Protective Effects of Sophoraflavanone G by Inhibiting TNF-α-Induced MMP-9-Mediated Events in Brain Microvascular Endothelial Cells
Tsong-Hai Lee,
Jiun-Liang Chen,
Ming-Ming Tsai
et al.
Abstract:The regulation of matrix metalloproteinases (MMPs), especially MMP-9, has a critical role in both physiological and pathological events in the central nervous system (CNS). MMP-9 is an indicator of inflammation that triggers several CNS disorders, including neurodegeneration. Tumor necrosis factor-α (TNF-α) has the ability to stimulate the production of different inflammatory factors, including MMP-9, in several conditions. Numerous phytochemicals are hypothesized to mitigate inflammation, including the CNS. A… Show more
“…al. studied the effect of Sophoraflavanone G on the inhibition of MMP-9 expression in brain microvascular endothelial cells as a novel strategy for mitigating neuroinflammation, a common thread in neurodegenerative diseases [ 1 ]. Their study elegantly demonstrates the potential for phytochemicals to disrupt the deleterious cascade of inflammatory events triggered by TNF-α, highlighting a promising therapeutic pathway.…”
The intricate interplay of cytokines within the inflammatory response serves as a cornerstone of both the maintenance of physiological homeostasis and the pathogenesis of proinflammatory diseases [...]
“…al. studied the effect of Sophoraflavanone G on the inhibition of MMP-9 expression in brain microvascular endothelial cells as a novel strategy for mitigating neuroinflammation, a common thread in neurodegenerative diseases [ 1 ]. Their study elegantly demonstrates the potential for phytochemicals to disrupt the deleterious cascade of inflammatory events triggered by TNF-α, highlighting a promising therapeutic pathway.…”
The intricate interplay of cytokines within the inflammatory response serves as a cornerstone of both the maintenance of physiological homeostasis and the pathogenesis of proinflammatory diseases [...]
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