Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens

Fan, Yuying; Zhou, Wenzhu; Li, Guili; Liu, Xuesong; Zhong, Peng; Liu, Kexin; Liu, Yun; Wang, Dong

doi:10.1016/j.psj.2024.103541

Poultry Science

2024

DOI: 10.1016/j.psj.2024.103541

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Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens

Yuying Fan,

Wenzhu Zhou,

Guili Li

et al.

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Protective effects of sodium humate on the intestinal barrier damage of Salmonella Typhimurium‐challenged broilers

Ma,

Zou,

Sun

et al. 2024

Animal Science Journal

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Salmonella Typhimurium (S. Typhimurium) infections can lead to severe intestinal damage and reduce growth performance in broilers. Thus, this study examined the potential mitigating impact of sodium humate (HNa) on intestinal barrier damage resulting from S. Typhimurium infection in broilers. A total of 320 1‐day‐old Arbor Acres broilers were randomly assigned into 5 treatments with 8 replicates. On d 22–24, broilers in the CON group were challenged with 1 ml of PBS, while broilers in the other groups were challenged with 1 ml of 3 × 109 CFU/ml S. Typhimurium, daily. Dietary administration with 4 g/kg of HNa increased (P < 0.05) the final body weight, jejunal secretory immunoglobulin A (sIgA), total antioxidant capacity (T‐AOC), total superoxide dismutase (T‐SOD), and catalase (CAT) levels as compared with the MOD group broilers. Furthermore, HNa alleviated intestinal barrier damage by increasing villus height (VH), upregulating protein expression of Occludin, Claudin‐1, and zonula occludens‐1 (ZO‐1), inhibiting toll‐like receptor 4 (TLR4)/nuclear factor kappa‐B (NF‐κB) signaling pathway activation, and decreasing the secretion of inflammatory cytokines (P < 0.05). Collectively, the present study showed that HNa mitigated intestinal barrier damage induced by S. Typhimurium infection in broilers.

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Protective effects of sodium humate on the intestinal barrier damage of Salmonella Typhimurium‐challenged broilers

Ma,

Zou,

Sun

et al. 2024

Animal Science Journal

View full text Add to dashboard Cite

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Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens

Cited by 1 publication

References 57 publications

Protective effects of sodium humate on the intestinal barrier damage of Salmonella Typhimurium‐challenged broilers

Protective effects of sodium humate on the intestinal barrier damage of Salmonella Typhimurium‐challenged broilers

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