Protective effects of selenium against sister chromatid exchange induced by AFG 1 in human lymphocytes in vitro

Abstract

<jats:p> Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic and teratogenic to different species of animals. Besides, at low concentrations, Selenium (Se<jats:sup>4+</jats:sup>) is antimutagenic and anticarcinogenic while it is toxic, mutagenic and carcinogenic at high concentrations. In this study, we aimed to evaluate the effect of Se<jats:sup>4+</jats:sup> against aflatoxin GAFG<jats:sub>1</jats:sub> (AFG<jats:sub>1</jats:sub>) on blood cultures in relation to induction of sister chromatid exchange (SCE). The results showed that at 0.4 and 0.8 parts per million (ppm) concentration of AFG<jats:sub>1</jats:sub>, the frequency of SCE increased in cultured human lymphocytes. When different concentration of Se<jats:sup>4+</jats:sup> (0.08 and 8 ppm) were added to AFG<jats:sub>1</jats:sub>, the frequencies of SCE decreased. Howewer, when 800 ppm concentration of Se<jats:sup>4+</jats:sup> together with 0.08 ppm AFG<jats:sub>1</jats:sub> were added to cell division inhibited in the cultures. Results suggested that Se<jats:sup>4+</jats:sup> could effectively inhibit AFG<jats:sub>1</jats:sub>-induced SCE. Besides, the protective role of Se<jats:sup>4+</jats:sup> against AFG<jats:sub>1</jats:sub>-induced SCE is probably related to its doses. </jats:p>

Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review

“…It is noteworthy, however, that humoral immunity and cell-mediated immunity might not always be distinguishable. For instance, the deregulation of dendritic cell proliferation and expression of TLRs can affect both innate and adaptive immunity since such antigen-producing cells serve as critical intermediaries for both forms of the immune response [108,109].…”