Protective effects of Sasa veitchii extract on acute ethanol‐induced hepatotoxicity in mice

Abstract

AimHigh alcohol consumption leads to alcohol‐related disease. The aim of this study was to explore the effects of Sasa veitchii extract (SE) on ethanol‐induced liver injury.MethodsOf four groups of 7‐week‐old male mice (control, SE, ethanol, and SE + ethanol groups), SE and SE + ethanol groups were orally treated with SE once a day for 3 days. Twenty‐four hours after the last administration, the SE + ethanol and ethanol groups were intraperitoneally injected with ethanol (2 g/kg). The mice in each group were euthanized 24 h after ethanol administration, and blood and livers were collected.ResultsHistopathological examination of the livers of ethanol‐treated mice revealed a depletion of glycogen. Ethanol injection resulted in high plasma levels of alanine aminotransferase and aspartate aminotransferase and high levels of hepatic lipid peroxidation and inflammatory cytokines. Pretreatment with SE reversed all these changes in SE + ethanol mice compared to that in the ethanol group. Moreover, SE injection increased the hepatic protein levels of aldehyde dehydrogenase 2.ConclusionOur results show that SE protected the mice against acute ethanol‐induced hepatic injury by modulating oxidative stress and ethanol metabolism, and hence, could be explored for treatment of alcohol‐related disease.

Sasa veitchii extract alleviates nonalcoholic steatohepatitis in methionine–choline deficient diet‐induced mice by regulating peroxisome proliferator‐activated receptor alpha

“…We previously used high‐performance liquid chromatography to confirm the components of SE and demonstrated that SE showed a broad peak and a sharp peak corresponding to Cu–Chl [18]. We previously reported that Cu–Chl did not show any protective effect against EtOH‐induced hepatotoxicity or phenytoin‐induced cell proliferation inhibition [21, 54]. Therefore, we speculated that the active components of SE were represented by unknown substances with a broad peak.…”

“…We have previously demonstrated that Sasa veitchii extract (SE) reduced acetaminophen‐induced acute hepatic injury and carbon tetrachloride‐induced acute and chronic hepatotoxicity in mice [18–20]. We also reported that oxidative stress‐induced hepatic injury induced by acute ethanol administration was attenuated by SE pre‐administration in mice [21]. Therefore, we hypothesized that SE might exert protective effects against other hepatic injury models, such as NASH.…”