Protective effects of resveratrol on hepatic ischemia reperfusion injury in streptozotocin-induced diabetic rats

Aktaş, Hanife Şerife; Ozel, Yahya; Ahmad, Sarfraz; Pençe, Halime Hanım; Ayaz-Adakul, Betul; Kudaş, İlyas; Tetik, Şermin; Şekerler, Turgut; Canbey-Göret, Ceren; Kabasakal, Levent; Elçioğlu, Hatice

doi:10.1007/s11010-019-03582-z

Cited by 21 publications

(10 citation statements)

References 27 publications

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“…Our results are supported by multiple studies reporting potent anti-inflammatory effects of resveratrol in the kidneys, as shown in rat mesangial cell and human renal epithelial cells in vitro, for instance, and in several renal in vivo inflammation models as recently reviewed by Den Hartogh and colleagues [44]. Furthermore, anti-inflammatory and anti-oxidant effects of resveratrol were described in hepatic ischemic reperfusion injuries in diabetic rats [45] and in experimental as well as in clinical non-alcoholic fatty liver disease [46,47]. In addition, pronounced systemic disease-alleviating effects of resveratrol could be assessed in experimental systemic lupus erythematosus [40].…”

Section: Discussionsupporting

confidence: 87%

Resveratrol Alleviates Acute Campylobacter jejuni Induced Enterocolitis in a Preclinical Murine Intervention Study

et al. 2020

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The polyphenolic compound resveratrol has been shown to exert health-beneficial properties. Given globally emerging Campylobacter infections in humans, we addressed potential anti-pathogenic, immuno-modulatory and intestinal epithelial barrier preserving properties of synthetic resveratrol in the present preclinical intervention study applying a murine acute campylobacteriosis model. Two days following peroral C. jejuni infection, secondary abiotic IL-10−/− mice were either subjected to resveratrol or placebo via the drinking water. Whereas placebo mice suffered from acute enterocolitis at day 6 post-infection, resveratrol treatment did not only lead to improved clinical conditions, but also to less pronounced colonic epithelial apoptosis as compared to placebo application. Furthermore, C. jejuni induced innate and adaptive immune cell responses were dampened in the large intestines upon resveratrol challenge and accompanied by less colonic nitric oxide secretion in the resveratrol versus the placebo cohort. Functional analyses revealed that resveratrol treatment could effectively rescue colonic epithelial barrier function in C. jejuni infected mice. Strikingly, the disease-alleviating effects of resveratrol could additionally be found in extra-intestinal and also systemic compartments at day 6 post-infection. For the first time, our current preclinical intervention study provides evidence that peroral resveratrol treatment exerts potent disease-alleviating effects during acute experimental campylobacteriosis.

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Section: Discussionsupporting

confidence: 87%

Resveratrol Alleviates Acute Campylobacter jejuni Induced Enterocolitis in a Preclinical Murine Intervention Study

et al. 2020

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“…However, Aktaş et al reported that Res reduced elevated MDA levels and increased GSH levels in liver tissue. [ 29 ] Similarly in the present study, Res reduced MDA levels that had increased following I/R of the abdominal infra‐renal aorta, while increasing GSH levels. No studies have to date investigated the effect of Res on apoptosis developing due to I/R of the abdominal infra‐renal aorta.…”

Section: Discussionsupporting

confidence: 82%

“…Necrosis‐related wide edematous fields, vascular congestion, and widespread periportal inflammation have been reported in remark cords. [ 1,29 ] Hüseyin et al reported vacuolization in hepatocytes, parenchymal necrosis, and vascular congestion. [ 30 ] Santos et al reported widespread edematous areas and vascular congestion due to aortic I/R.…”

Section: Discussionmentioning

confidence: 99%

The hepatoprotective potential of resveratrol in an experimental model of ruptured abdominal aortic aneurysm via oxidative stress and apoptosis

Bilen

Mercantepe

Tümkaya

et al. 2021

J Biochem & Molecular Tox

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The mortality rate in ruptured abdominal aortic aneurysms can today be reduced through cardiovascular surgery. However, ischemia and reperfusion‐induced tissue damage develop due to aortic cross‐clamping applied during surgery. The present study aimed to reduce oxidative stress‐induced hepatic damage resulting from ischemia and reperfusion due to aortic cross‐clamping during surgery by means of resveratrol administration. Forty male Sprague–Dawley rats were randomly assigned into four groups: control (healthy), glycerol+ischemia/reperfusion (I/R) (sham), I/R, and I/R + Resveratrol. In all groups scheduled for I/R, 60 min of shock was followed by 60 min of ischemia. In the I/R + Resveratrol group, 10 mg/kg of resveratrol was administered 15 min before ischemia and immediately before reperfusion via the intraperitoneal route. In addition, 120 min of reperfusion was applied under anesthesia after ischemia in all groups. Intralobar and interlobar necrosis, vascular congestion, and edematous fields resulting from aortic occlusion were present. Liver tissue malondialdehyde (MDA) levels and cleaved caspase‐3 positivity increased, while glutathione (GSH) levels decreased. However, resveratrol administration reduced intralobular and interlobar necrosis, vascular congestion and edematous fields, cleaved caspase‐3 positivity, and MDA levels, and increased GSH levels. Our findings suggest that resveratrol is effective against aortic occlusion‐induced liver injury by reducing oxidative stress and apoptosis.

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“…This is also consistent with previous rat cardiac I/R studies which revealed significantly increased MDA levels (34). In line with this, several trauma models for ischemia in different organs (35)(36)(37) have suggested that resveratrol not only decreased the MDA levels, but also improved the functional outcomes (14).…”

Section: Discussionmentioning

confidence: 69%

The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

Avnioğlu

Güngör

Kurutaş

et al. 2022

Revista Romana De Medicina De Laborator

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Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.

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Protective effects of resveratrol on hepatic ischemia reperfusion injury in streptozotocin-induced diabetic rats

Cited by 21 publications

References 27 publications

Resveratrol Alleviates Acute Campylobacter jejuni Induced Enterocolitis in a Preclinical Murine Intervention Study

Resveratrol Alleviates Acute Campylobacter jejuni Induced Enterocolitis in a Preclinical Murine Intervention Study

The hepatoprotective potential of resveratrol in an experimental model of ruptured abdominal aortic aneurysm via oxidative stress and apoptosis

The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

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