Protective Effects of Resveratrol on Spleen and Ileum in Rats Subjected to Ischemia-Reperfusion

Karabulut, Aysun Bay; Kırımlıoğlu, Vedat; Kırımlıoğlu, Hale; Yilmaz, Sezai; Işık, Burak; Isikgil, O.

doi:10.1016/j.transproceed.2006.01.017

Cited by 23 publications

(25 citation statements)

References 14 publications

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“…Additionally, the different dosages, the application methods and reperfusion time chosen by Hassan-Khabbar et al could give rise to the current discrepancy. Furthermore, the dosage of resveratrol in our study is supported by several other studies (Karabulut et al 2006;Elmali et al 2007;Juan et al 2009). …”

Section: Discussionsupporting

confidence: 90%

“…Besides its antioxidant properties, it interferes with the release of inflammatory mediators from activated PMNLs and inhibits neutrophil infiltration, thus modulating the function of PMNLs. Increased concentrations of MDA indicate the degree of lipid peroxidation verifying the oxidative damage in tissue thus it becomes a well-known marker of tissue injury (Karabulut et al 2006). In the present study, a substantial increase in MDA levels in I/R and I/R+vehicle groups was noted.…”

Section: Discussionsupporting

confidence: 61%

“…NO plays a major role in maintaining mucosal integrity and is a significant mediator of vascular tone (Karabulut et al 2006). Its protective or detrimental effect in intestinal I/R injury still remains undetermined.…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol, a Natural Antioxidant, Attenuates Intestinal Ischemia/Reperfusion Injury in Rats

Özkan

Yüzbaşıoğlu

Çıralık

et al. 2009

Tohoku J. Exp. Med.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 61%

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Resveratrol, a Natural Antioxidant, Attenuates Intestinal Ischemia/Reperfusion Injury in Rats

Özkan

Yüzbaşıoğlu

Çıralık

et al. 2009

Tohoku J. Exp. Med.

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“…NO levels was correlated with MDA levels and histogic injury scores. This result parallels those in other reports that indicate the overproduction of NO as a detrimental factor responsible for the pathogenesis of bowel in inflammatory response in I/R [30,31].…”

Section: Discussionsupporting

confidence: 92%

Orchiectomy or testosterone receptor blockade reduces intestinal mucosal damage caused by ischemia-reperfusion insult

et al. 2007

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The aim of the present study was to investigate whether orchiectomy or administration of flutamide an antagonist of the testosterone receptor can reduce oxidative stress and histologic damage in the rat small bowel subjected to mesenteric ischemia/reperfusion (I/R) injury. A total of 32 Sprague-Dawley rats were divided into four groups. Group 1 was control (sham), group 2 was I/R, group 3 was I/R plus orchiectomy (orchiectomy was performed 14 days before I/R), group 4 was I/R plus flutamide (flutamide was given throughout 14 days before mesenteric IR). Rats were subjected to 45 min of mesenteric ischemia followed by 3 h of reperfusion. The levels of ileal malondialdehyde (MDA) and nitric oxide (NO) were found to be significantly lower in orchiectomy and flutamide treatment groups compared with I/R group (P < 0.05). The histopathological injury scores were consistent with the MDA and NO levels. These results suggest that castration or testosterone receptor blockade decreases the level of intestinal I/R injury in male rats and it is an another example for disease variations based on gender differences.

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“…It is a crucial enzyme that keeps the balance of oxidation and anti-oxidation in the body and protects organisms from the attack of free radicals. The activity level of SOD reflects the body's ability to indirectly eliminate oxygen free radicals [26].…”

Section: Discussionmentioning

confidence: 99%

Shenduning Granule Attenuates Renal Injury from Oxidative Stress through the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway

Xiaojun¹,

Hu²

2019

Pharmacology

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Background: Systemic oxidative stress has been reported to play a central role in the pathogenesis of kidney function decline. The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is one of the important endogenous antioxidant stress pathways in cells. This study aims to investigate whether shenduning granule can ameliorate oxidative stress in kidney tissues by activating the Nrf2/ARE pathway, and explores the detailed underlying mechanism. Methods: A total of 120 male Sprague-Dawley rats were randomly assigned to the sham-operated and operation groups. Rats in the operation group underwent 5/6 nephrectomy. Two weeks later, rats in the operation group were further randomly divided into 5 groups: model group, low-dose, medium-dose and high-dose shenduning granule groups, and losartan group. Rats in each group were given the same volume of corresponding liquid orally. Serum creatinine (SCr), blood urea nitrogen (BUN), 24-h urinary protein, malondialdehyde (MDA) and superoxide dismutase (SOD), Nrf2, heme oxygenase-1 (HO-1), and γ-glutamyl-cysteine synthetase (γ-GCS) were determined. Results: Shenduning granule could markedly elevate HO-1, NRF2, γ-GCS and SOD (p < 0.05), and significantly decreased MDA, 24-h urinary protein, SCr and BUN in rats (p < 0.05). Conclusion: Shenduning granule can improve renal antioxidative stress activity in rats, exhibiting a renoprotective effect. The potential mechanism is likely exerted by the activation of the Nrf2/ARE pathway.

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Protective Effects of Resveratrol on Spleen and Ileum in Rats Subjected to Ischemia-Reperfusion

Cited by 23 publications

References 14 publications

Resveratrol, a Natural Antioxidant, Attenuates Intestinal Ischemia/Reperfusion Injury in Rats

Resveratrol, a Natural Antioxidant, Attenuates Intestinal Ischemia/Reperfusion Injury in Rats

Orchiectomy or testosterone receptor blockade reduces intestinal mucosal damage caused by ischemia-reperfusion insult

Shenduning Granule Attenuates Renal Injury from Oxidative Stress through the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway

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