Protective effects of resveratrol against high ambient temperature‐induced spleen dysplasia in broilers through modulating splenic redox status and apoptosis

Cheng, Zhang; Chen, Kaikai; Xian-qing, Zhao; Zhao, Geng

doi:10.1002/jsfa.9084

Cited by 38 publications

(40 citation statements)

References 35 publications

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“…It has been demonstrated that the stimulation of endogenous antioxidant activity is a major contributor to depressing ROS‐derived oxidative stress . As the first endogenous antioxidant defense, SOD, CAT and GPx are suggested to be important antioxidant enzymes responsible for the removal of ROS . In this study, the activities and expressions of CAT, SOD and GPx were efficiently increased by oral administration of l ‐ methionine, suggesting that the induction of endogenous antioxidant response was clearly dose dependent on l ‐ methionine availability.…”

Section: Discussionmentioning

confidence: 59%

l‐Methionine activates Nrf2‐ARE pathway to induce endogenous antioxidant activity for depressing ROS‐derived oxidative stress in growing rats

Wang

Liang

et al. 2019

J Sci Food Agric

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BACKGROUND Methionine is an essential sulfur‐containing amino acid. To elucidate the influence of l‐methionine on activation of the nuclear factor erythroid 2‐related factor 2–antioxidant responsive element (Nrf2‐ARE) antioxidant pathway to stimulate the endogenous antioxidant activity for depressing reactive oxygen species (ROS)‐derived oxidative stress, male Wistar rats were orally administered l‐methionine daily for 14 days. RESULTS With the intake of l‐methionine, Nrf2 was activated by l‐methionine through depressing Keap1 and Cul3, resulting in upregulation of ARE‐driven antioxidant expression (glutamate cysteine ligase catalytic subunit, glutamate cysteine ligase modulatory subunit, glutathione synthase (GS), catalase (CAT), superoxide dismutase (SOD), heme oxygenase 1, NAD(P)H:quinone oxidoreductase 1, glutathione reductase (GR), glutathione S‐transferase (GST), glutathione peroxidase (GPx)) with increasing l‐methionine availability. Upon activation of Nrf2, glutathione synthesis was increased through upregulated expression of methionine adenosyltransferase, S‐adenosylhomocysteine hydrolase, cystathionine β‐synthase, cystathionine γ‐lyse, glutamate cysteine ligase (GCL) and GS, while hepatic expressions of methionine sulfoxide reductases (MsrA, MsrB2, MsrB3) and hepatic enzyme activities (CAT, SOD, GCL, GR, GST, GPx) were uniformly stimulated with increasing consumption of l‐methionine. As a result, hepatic content of ROS and MDA were effectively reduced by l‐methionine intake. CONCLUSION The present study demonstrates that methionine availability plays a critical role in activation of the Nrf2‐ARE pathway to induce an endogenous antioxidant response for depressing ROS‐derived oxidative stress, which is primarily attributed to the stimulation of methionine sulfoxide reductase expression and glutathione synthesis. © 2019 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 59%

l‐Methionine activates Nrf2‐ARE pathway to induce endogenous antioxidant activity for depressing ROS‐derived oxidative stress in growing rats

Wang

Liang

et al. 2019

J Sci Food Agric

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“…Khazaei et al demonstrated that RSV modulated the expression of elevated RAGE in the liver tissue of diabetic rats; however, the possible mechanisms are unknown . Furthermore, Zhang et al suggest that the inhibition of peroxisome proliferator‐activated‐receptor‐γ (PPARγ) is a possible mechanism for the modulatory effect of RSV on the expression of RAGE . More importantly, evidence exists that RSV disrupts AGE/RAGE signaling by inhibiting MAPK p38, ERK, and NF‐κB pathways …”

Section: Discussionmentioning

confidence: 99%

“…38 Furthermore, Zhang et al suggest that the inhibition of peroxisome proliferatoractivated-receptor-γ (PPARγ) is a possible mechanism for the modulatory effect of RSV on the expression of RAGE. 62 More importantly, evidence exists that RSV disrupts AGE/RAGE signaling by inhibiting MAPK p38, ERK, and NF-κB pathways. 27 The MGO-degrading capacity of RSV has also emerged as an essential mechanism for detoxifying AGEs.…”

Section: Discussionmentioning

confidence: 99%

The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

et al. 2019

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Accumulation of advanced glycation end products (AGEs) promotes the generation of free radicals, which leads to chronic oxidative stress predisposing to chronic oxidative stress, inflammation, and related diseases. This systematic review aimed to determine the effect of resveratrol (RSV) on AGE‐induced toxicity and its deleterious consequences. A comprehensive search was performed through literature were published until December 2018 using relevant keywords. The databases that were used for the search were PubMed, Scopus, Embase, ProQuest, and Google Scholar. A total of 29 eligible studies were found and included in the review for the analysis. Except one, all studies showed suppressing effects for RSV on the production of AGEs or receptor for advanced glycation end products (RAGE) and its detrimental consequences including oxidative stress, inflammatory response, cellular immune reactions, insulin response, and atherosclerosis. RSV exerts its effects through influencing RAGE, nuclear factor kappa B (NF‐κB), peroxisome proliferator‐activated receptor (PPAR) γ, and transforming growth factor (TGF)‐β activities. This review suggests that RSV has got potential to decrease AGEs toxicity and inhibit the AGE‐induced complications. More clinical trials are suggested to evaluate the beneficial effect of RSV on AGEs in chronic metabolic diseases.

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“…The protein concentration of the supernatant was assayed by the Bradford method with bovine serum albumin as the standard. The content of serum d ‐lactic acid and jejunum mucosa malondialdehyde (MDA) and protein carbonyl (PC), and the activities of jejunum mucosa total antioxidant capacity (T‐AOC), catalase (CAT), glutathione peroxidase (GSH‐PX) and total superoxide dismutase (T‐SOD) were measured in triplicate using the corresponding commercial assay kits (Nanjing Jiancheng Institute of Bioengineering, Nanjing, China), according to the manufacturer's instructions …”

Section: Methodsmentioning

confidence: 99%

Effect of l‐theanine on growth performance, intestinal development and health, and peptide and amino acid transporters expression of broilers

et al. 2020

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BACKGROUND: L-Theanine has multiple beneficial biological activities. However, there is little information about the use of L-theanine in broiler production. Therefore, this study investigated the effect of L-theanine on growth performance, intestinal development and health, and the mRNA levels of intestinal peptide and amino acid (AA) transporters of broilers. RESULTS: Body weight and average daily gain were increased by L-theanine, whereas feed to gain ratio was decreased (quadratic, P < 0.05). Notably, the relative weight of duodenum, jejunum and ileum, villus height, villus height to crypt depth ratio, the jejunal activities of glutathione peroxidase, total antioxidant capacity, catalase and total superoxide dismutase were increased linearly and/or quadratically by L-theanine (P < 0.05), whereas crypt depth, serum D-lactic acid, and jejunal protein carbonyls and malondialdehyde content were decreased linearly and/or quadratically (P < 0.05). Moreover, L-theanine enhanced the jejunal mRNA levels of occludin, claudin-1, E-cadherin, zona occludens-1, di-and tripeptide transporter, excitatory AA transporter 3, Na + -independent cationic AA transporter 1, Na + -independent cationic and zwitterionic AA transporter, Na + -and Cl − -dependent neutral and cationic AA transporter, Na + -independent cationic and Na + -dependent neutral AA transporter (y+LAT) 1, y+LAT2, Na + -independent branched-chain and aromatic AA transporter, and heavy chain corresponding to the b ∘,+ transport system (linear and/or quadratic, P < 0.05). CONCLUSIONS: L-Theanine beneficially affected the growth performance of broilers by improving intestinal development andhealth, and the intestinal mRNA levels of AA and peptide transporters. Therefore, L-theanine has the potential to be a promising feed additive for broilers. Jejunum morphology analysisJejunum morphology was measured as previously described. 21,22 Briefly, the formalin-fixed jejunal samples were embedded in paraffin wax, cut into about 5 μm transverse sections, mounted on glass slides, and then stained with hematoxylin and eosin. Crypt depth and villus height were determined with an image processing and analysis system (Leica Imaging Systems Ltd, Cambridge, UK). Fifteen well-orientated villi and their adjacent crypts from each intestinal sample were measured. Serum D-lactic acid content and jejunum antioxidant status analysisThe mucosa of jejunum was homogenized in ice-cold physiological saline solution (1:9, w/v). The homogenate was centrifuged at 2500 × g for 8 min at 4 ∘ C and then the supernatant was collected for antioxidant enzyme activity and metabolite content analysis at appropriate dilution. The protein concentration of the supernatant was assayed by the Bradford method with bovine serum albumin as the standard. The content of serum D-lactic acid and RESULTS Growth performanceGrowth performance data are shown in Table 3. L-Theanine elevated BW at days 21 and 42 (quadratic, P < 0.05). From days 1 to 21, L-theanine increased ADG (quadratic, P < 0.05) and decreased

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Protective effects of resveratrol against high ambient temperature‐induced spleen dysplasia in broilers through modulating splenic redox status and apoptosis

Cited by 38 publications

References 35 publications

l‐Methionine activates Nrf2‐ARE pathway to induce endogenous antioxidant activity for depressing ROS‐derived oxidative stress in growing rats

l‐Methionine activates Nrf2‐ARE pathway to induce endogenous antioxidant activity for depressing ROS‐derived oxidative stress in growing rats

The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

Effect of l‐theanine on growth performance, intestinal development and health, and peptide and amino acid transporters expression of broilers

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