Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite

Olas, Beata; Nowak, Paweł; Kołodziejczyk, Joanna; Ponczek, Michał B.; Wachowicz, Barbara

doi:10.1016/j.jnutbio.2005.05.010

Cited by 79 publications

(59 citation statements)

References 40 publications

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“…Hepatic MDA was significantly corrected in all treatment groups, while hepatic GSH was significantly corrected in the UDCA, RSV, and NAC groups, but not in UDCA + RSV or UDCA + NAC groups. This comes in agreement with previous studies on UDVA (Sokolovic et al, 2013), RSV (Anderson & Prolla, 2009;Olas et al, 2006;Zheng et al, 2012), and NAC (Sahin & Alatas, 2013). Interestingly, UDCA alone showed better lowering in MDA level when compared with UDCA + RSV or UDCA + NAC, but not when compared with RSV or NAC alone, indicating somewhat antagonistic effect between UDCA and RSV or NAC.…”

Section: Discussionsupporting

confidence: 92%

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Ali

Messiha

Abdellatif

2015

Pharmaceutical Biology

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(2016) Protective effect of ursodeoxycholic acid, resveratrol, and Nacetylcysteine on nonalcoholic fatty liver disease in rats, Pharmaceutical Biology, 54:7, 1198-1208, DOI: 10.3109/13880209.2015 -a), glucose, albumin, renal functions (urea, creatinine), lipid profile (total cholesterol; TC, triglycerides, high density lipoproteins, low density lipoproteins; LDL-C, very low density lipoproteins, leptin), and oxidative stress markers (hepatic malondialdehyde; MDA, glutathione; GSH, glutathione-S-transferase; GST) were measured using automatic analyzer, colorimetric kits, and ELISA kits, supported by a liver histopathological study.Results: RSV and NAC administration significantly improved liver index (RSV only), alanine transaminase (52, 52%), TNF-a (70, 70%), glucose (69, 80%), albumin (122, 114%), MDA (55, 63%), GSH (160, 152%), GST (84, 84%), TC (86, 86%), LDL-C (83, 81%), and leptin (59, 70%) levels compared with steatosis control values. A combination of RSV or NAC with UDCA seems to ameliorate their effects. Discussion and conclusion: RSV and NAC are effective on NAFLD through antioxidant, antiinflammatory, and lipid-lowering potentials, where as RSV seems better than UDCA or NAC.

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Section: Discussionsupporting

confidence: 92%

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Ali

Messiha

Abdellatif

2015

Pharmaceutical Biology

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“…Resveratrol is an atoxic phytoestrogen, which holds great promise as an anti-oxidant, antiinflammatory and/or antitumor agent for various therapeutical indications [9][10][11][12][13][14][15][16][17]. The present review focuses on some of the mechanisms by which resveratrol may reverse or delay the symptoms of cardiovascular aging.…”

Section: Introductionmentioning

confidence: 99%

Vascular Dysfunction in Aging: Potential Effects of Resveratrol, an Anti- Inflammatory Phytoestrogen

Labinskyy¹,

Csiszár²,

Veress³

et al. 2006

CMC

132

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Epidemiological studies demonstrated that even in the absence of other risk factors (e.g. diabetes, hypertension, hyperhomocysteinemia, hypercholesterolemia), advanced age itself significantly increases cardiovascular morbidity by enhancing vascular oxidative stress and inflammation. Because the population in the Western world is rapidly aging, there is a substantial need for pharmacological interventions that delay the functional decline of the cardiovascular system. Resveratrol is an atoxic phytoestrogen found in more than 70 plants including grapevine and berries. Recent data suggest that nutritional intake of resveratrol and other polyphenol compounds may contribute to the "French paradox", the unexpectedly low cardiovascular morbidity in the Mediterranean population. There is increasing evidence that resveratrol exerts multifaceted antioxidant and/or anti-inflammatory effects in various disease models. Importantly, resveratrol was reported to slow aging and increase lifespan in simple organisms and has been suggested as a potential calorie restriction mimetic. Resveratrol has also been reported to activate NAD-dependent histone deacetylases (sirtuins), which may contribute to its anti-aging effects. This review focuses on the role of oxidative stress and inflammation in cardiovascular dysfunction in aging, and on emerging anti-aging therapeutic strategies offered by resveratrol and other polyphenol compounds.

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“…The exposure of proteins to ONOO -results in the oxidation of cysteine, methionine and tryptophane, the nitration of tyrosine, the formation of dityrosine, the fragmentation of molecules, and the formation of carbonyl groups [11,15,16]. Our earlier results showed that exposure of human plasma or blood platelets to peroxynitrite causes the oxidation and nitration of various proteins and the oxidation of lipids [15,16], and that the resveratrol present in dietary sources and supplemented in the human diet, like other antioxidants (uric acid and deferoxamine), may suppress the toxic action of ONOO -on human plasma [16] or blood platelets [15].…”

Section: Introductionmentioning

confidence: 99%

The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipids

Nowak

Saluk-Juszczak

Olas

et al. 2006

Cellular and Molecular Biology Letters

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Many selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors or drugs. The effects of a new selenocompound -bis(2-aminophenyl)-diselenide on oxidative/nitrative changes in human plasma proteins induced by peroxynitrite (ONOO -) were studied in vitro and compared with the those of ebselen, a wellknown antioxidant. We also studied the role of the tested selenocompounds in peroxynitrite-induced plasma lipid peroxidation. Exposure of the plasma to peroxynitrite (0.1 mM) resulted in an increase in the level of carbonyl groups and nitrotyrosine residues in plasma proteins (estimated using the ELISA method and Western blot analysis). In the presence of different concentrations (0.025-0.1 mM) of the tested selenocompounds, 0.1 mM peroxynitrite caused a distinct decrease in the level of carbonyl group formation and tyrosine nitration in plasma proteins. Moreover, these selenocompounds also inhibited plasma lipid peroxidation induced by ONOO -(0.1 mM). The obtained results indicate that in vitro bis(2-aminophenyl)-diselenide and ebselen have very similar protective effects against peroxynitrite-induced oxidative/nitrative damage to human plasma proteins and lipids.

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Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite

Cited by 79 publications

References 40 publications

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Vascular Dysfunction in Aging: Potential Effects of Resveratrol, an Anti- Inflammatory Phytoestrogen

The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipids

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