Protective Effects of Radix Sophorae Flavescentis Carbonisata-Based Carbon Dots Against Ethanol‐Induced Acute Gastric Ulcer in Rats: Anti-Inflammatory and Antioxidant Activities

Hu, Jie; Luo, Jian; Zhang, Meiling; Wu, Jiashu; Zhang, Yue; Kong, Hui; Qu, Huihua; Cheng, Guoliang; Zhao, Yan

doi:10.2147/ijn.s289515

Cited by 36 publications

(36 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[Typhaceae] (Yan et al, 2017), Juncus effusus L. [Juncaceae] , Sophora flavescens Aiton [Fabaceae] (Hu et al, 2021), Paeonia lactiflora Pall. [Paeoniaceae] (Zhao et al, 2020) and Phellodendron chinense C. K. Schneid.…”

Section: The Biological Activities and Mechanism Of Traditional Chine...mentioning

confidence: 99%

Chinese Medicinal Herb-Derived Carbon Dots for Common Diseases: Efficacies and Potential Mechanisms

Zhao

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

The management of hemorrhagic diseases and other commonly refractory diseases (including gout, inflammatory diseases, cancer, pain of various forms and causes) are very challenging in clinical practice. Charcoal medicine is a frequently used complementary and alternative drug therapy for hemorrhagic diseases. However, studies (other than those assessing effects on hemostasis) on charcoal-processed medicines are limited. Carbon dots (CDs) are quasi-spherical nanoparticles that are biocompatible and have high stability, low toxicity, unique optical properties. Currently, there are various studies carried out to evaluate their efficacy and safety. The exploration of using traditional Chinese medicine (TCM) -based CDs for the treatment of common diseases has received great attention. This review summarizes the literatures on medicinal herbs-derived CDs for the treatment of the difficult-to-treat diseases, and explored the possible mechanisms involved in the process of treatment.

show abstract

Section: The Biological Activities and Mechanism Of Traditional Chine...mentioning

confidence: 99%

Chinese Medicinal Herb-Derived Carbon Dots for Common Diseases: Efficacies and Potential Mechanisms

Zhao

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Recently, Hu et al [ 115 ] showed Radix Sophorae Flavescentis carbonisata (RSFC)-based CDs against an ethanol-induced acute gastric ulcer in rats by inhibiting TNF-α and IL-6 releases via downregulation of NF-κB pathway. RSFC has been extensively harvested for treating ulcerative diseases throughout the body.…”

Section: Applications Of Hm-cdsmentioning

confidence: 99%

“…RSFC has been extensively harvested for treating ulcerative diseases throughout the body. The authors concluded that HM-CDs using high-temperature pyrolysis may have inherent bioactivities [ 115 ]. But the active ingredients are not revealed.…”

Section: Applications Of Hm-cdsmentioning

confidence: 99%

Herbal medicine derived carbon dots: synthesis and applications in therapeutics, bioimaging and sensing

et al. 2021

View full text Add to dashboard Cite

Since the number of raw material selections for the synthesis of carbon dots (CDs) has grown extensively, herbal medicine as a precursor receives an increasing amount of attention. Compared with other biomass precursors, CDs derived from herbal medicine (HM-CDs) have become the most recent incomer in the family of CDs. In recent ten years, a great many studies have revealed that HM-CDs tend to be good at theranostics without drug loading. However, the relevant development and research results are not systematically reviewed. Herein, the origin and history of HM-CDs are outlined, especially their functional performances in medical diagnosis and treatment. Besides, we sort out the herbal medicine precursors, and analyze the primary synthetic methods and the key characteristics. In terms of the applications of HM-CDs, medical therapeutics, ion and molecular detection, bioimaging, as well as pH sensing are summarized. Finally, we discuss the crucial challenges and future prospects.

show abstract

“…Due to the growing potential of CNDs in biomedical applications, studies have attempted to discern their use as therapeutic agents [30,[56][57][58][59][60][61].…”

Section: Therapymentioning

confidence: 99%

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Khan

Dunphy

Anike

et al. 2021

IJMS

View full text Add to dashboard Cite

Carbon nanodots (CNDs) are an emerging class of nanomaterials and have generated much interest in the field of biomedicine by way of unique properties, such as superior biocompatibility, stability, excellent photoluminescence, simple green synthesis, and easy surface modification. CNDs have been featured in a host of applications, including bioimaging, biosensing, and therapy. In this review, we summarize the latest research progress of CNDs and discuss key advances in our comprehension of CNDs and their potential as biomedical tools. We highlighted the recent developments in the understanding of the functional tailoring of CNDs by modifying dopants and surface molecules, which have yielded a deeper understanding of their antioxidant behavior and mechanisms of action. The increasing amount of in vitro research regarding CNDs has also spawned interest in in vivo practices. Chief among them, we discuss the emergence of research analyzing CNDs as useful therapeutic agents in various disease states. Each subject is debated with reflection on future studies that may further our grasp of CNDs.

show abstract

Protective Effects of Radix Sophorae Flavescentis Carbonisata-Based Carbon Dots Against Ethanol‐Induced Acute Gastric Ulcer in Rats: Anti-Inflammatory and Antioxidant Activities

Cited by 36 publications

References 70 publications

Chinese Medicinal Herb-Derived Carbon Dots for Common Diseases: Efficacies and Potential Mechanisms

Chinese Medicinal Herb-Derived Carbon Dots for Common Diseases: Efficacies and Potential Mechanisms

Herbal medicine derived carbon dots: synthesis and applications in therapeutics, bioimaging and sensing

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Contact Info

Product

Resources

About