Protective effects of quercetin glycosides, rutin, and isoquercetrin against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in rat pheochromocytoma (PC-12) cells

Magalingam, Kasthuri Bai; Radhakrishnan, Ammu Kutty; Haleagrahara, Nagaraja

doi:10.1177/0394632015613039

Cited by 71 publications

(40 citation statements)

References 48 publications

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“…Imipramine [247] Isobavachalcone [248] Isochlorogenic acid [167] Isoquercetin (Isoquercitrin) [249] Kaempferol [128,160,193,194] Kaempferol, 3-O-a-l arabinofuranoside-7-O-a-l-rhamnopyranoside [214] KR33493 [250] Kukoamine [251] Lestaurtinib [164] Lipoic acid [252][253][254] Luteolin [128] LY354740 [115] M10 [24] M30 (VAR10303) [112,255] M99 [24] Macranthoin G [256] Magnesium lithospermate B [257] [160,193,194,267] [18F]MPPF [107] MSX-3 [268] Myricetin [128,269,270] Myricitrin [271] Naringenin [128,272] Naringin [117,273,274] Nicotinamide adenine dinucleotide phosphate (NADPH) [275,276] Nicotinamide mononucleotide [277] Nitecapone [278] Nordihydroguaiaretic [160,193,194] Oleuropein…”

Section: Compound Name(s) Referencesmentioning

confidence: 99%

Metal Chelation Therapy and Parkinson’s Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs

Tosato

Marco

2019

Biomolecules

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The present review reports a list of approximately 800 compounds which have been used, tested or proposed for Parkinson’s disease (PD) therapy in the year range 2014–2019 (April): name(s), chemical structure and references are given. Among these compounds, approximately 250 have possible or established metal-chelating properties towards Cu(II), Cu(I), Fe(III), Fe(II), Mn(II), and Zn(II), which are considered to be involved in metal dyshomeostasis during PD. Speciation information regarding the complexes formed by these ions and the 250 compounds has been collected or, if not experimentally available, has been estimated from similar molecules. Stoichiometries and stability constants of the complexes have been reported; values of the cologarithm of the concentration of free metal ion at equilibrium (pM), and of the dissociation constant Kd (both computed at pH = 7.4 and at total metal and ligand concentrations of 10–6 and 10–5 mol/L, respectively), charge and stoichiometry of the most abundant metal–ligand complexes existing at physiological conditions, have been obtained. A rigorous definition of the reported amounts is given, the possible usefulness of this data is described, and the need to characterize the metal–ligand speciation of PD drugs is underlined.

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Section: Compound Name(s) Referencesmentioning

confidence: 99%

Metal Chelation Therapy and Parkinson’s Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs

Tosato

Marco

2019

Biomolecules

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“…In addition, several studies demonstrated the neuroprotective effects exerted by some quercetin glycosides such as rutin, isoquercetin and hyperoside in in vitro neuropathological models. As an instance, investigations on 6-OHDA-induced rat PC12 cells, an in vitro PD model, demonstrated that rutin and isoquercetin have not only a benefic effect on viability and on antioxidant machinery, but also have a direct antioxidant action (Magalingam et al, 2013(Magalingam et al, , 2014(Magalingam et al, , 2016 and modulate several genes to prevent neuronal cell death (Magalingam et al, 2015a). It is noteworthy that rutin has been demonstrated to have more neuroprotective effect with respect to isoquercetin, inducing higher cell viability and better functionality of some antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…2a). On the basis of the data present in literature concerning other quercetin glycosides, a dose of Q3,4'dG 100 μM was chosen to perform the subsequent experiments (Magalingam et al, 2013(Magalingam et al, , 2015a(Magalingam et al, , 2016.…”

Section: Effect Of Q34'dg On Hsps Proliferation and Viability Duringmentioning

confidence: 99%

Neuroprotective effects of quercetin 4’- O -β- d -diglucoside on human striatal precursor cells in nutrient deprivation condition

et al. 2018

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Several investigations have demonstrated neuroprotective effects of quercetin, a polyphenol widely present in nature, against neurotoxic chemicals, as well as in neuronal injury/neurodegenerative disease models. Most of these studies have been performed with quercetin aglycone and its metabolites, while scanty data are available on its glycosides. This study is aimed at investigating the neuroprotective effects of quercetin 3,4'-O-β-d-diglucoside (Q3,4'dG), isolated from the bulbs of the white cultivar (Allium cepa L.), using an in vitro model of human striatal precursor cells (HSPs), a primary culture isolated from the striatal primordium and previously characterized. To study the effect of Q3,4'dG on cell survival, HSPs were exposed to nutrient deprivation created by replacing culture medium with phosphate buffer saline (PBS). Our findings showed that Q3,4'dG treatment significantly promoted cell survival and strongly decreased apoptosis induced by nutrient deprivation, as evaluated by cell proliferation/death analyses. In addition, since the adhesive capacities of cells are essential for cell survival, the expression of some adhesion molecules, such as pancadherin and focal adhesion kinase, was evaluated. Interestingly, PBS exposure significantly decreased the expression of both molecules, while in the presence of Q3,4'dG this effect was prevented. This study provides evidence of a neuroprotective role exerted by Q3,4'dG and suggests its possible implication in sustaining neuronal survival for prevention and treatment of neurodegenerative disorders.

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“…These findings suggest that quercetin may provide a promising approach for the prevention and treatment of neurodegenerative diseases. Quercetin glycosides rutin and isoquercetin were reported to have neuroprotective effect against 6-OHDA-induced rat pheochromocytoma (PC-12) cells by significantly increasing the activities of catalase, superoxide dismutase, Glutathione peroxidase and glutathione that were reduced by 6-OHDA in PC-12 cells (Magalingam et al, 2016). There was no significant difference in the activation of glutathione peroxidase and glutathione enzymes between rutin and isoquercetin signifying that the two glycosides are equally important in protecting PC-12 cells against 6-OHDA toxicity.…”

Section: Effect On Quercetin On the Nervous System Disordersmentioning

confidence: 99%

Role of quercetin in the prevention and treatment of diseases: Mini review

Dibal¹,

Garba²,

Jacks³

2018

Braz. J. Biol. Sci.

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Quercetin is the most abundant flavonoid and one of the most important antioxidant of plant origin. The aim of the review was to describe quercetin and its role in the prevention and treatment of diseases. Articles were searched from internet databases using the following search words; quercetin, oxidative stress, quercetin and liver disease, quercetin and kidney disease, quercetin and hyperglycemia. The articles that met the selection criteria were used to describe quercetin and its role in the prevention and treatment of different diseases. The result showed that flavonoids are generally found at higher concentrations in outer layers of fruits and vegetables, onion has more quercetin than blackcurrants, broccoli, black grapes and apple. Quercetin and quercetin rich diets are used in the treatment and prevention of hyperglycemia, cardiovascular and kidney diseases, liver damage and nervous system disorders. In conclusion, quercetin is a naturally occurring flavonoid, more abundant in fruits and vegetables and are used in the treatment and prevention of many diseases.

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Protective effects of quercetin glycosides, rutin, and isoquercetrin against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in rat pheochromocytoma (PC-12) cells

Cited by 71 publications

References 48 publications

Metal Chelation Therapy and Parkinson’s Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs

Metal Chelation Therapy and Parkinson’s Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs

Neuroprotective effects of quercetin 4’- O -β- d -diglucoside on human striatal precursor cells in nutrient deprivation condition

Role of quercetin in the prevention and treatment of diseases: Mini review

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