Protective Effects of Quercetin Against Cadmium Chloride-Induced Oxidative Injury in Goat Sperm and Zygotes

Mao, Tingchao; Han, Chengquan; Wei, Biao; Zhao, Lu; Zhang, Qing; Deng, Ruizhi; Lee, Jun; Luo, Yan; Zhang, Yong

doi:10.1007/s12011-018-1255-8

Cited by 38 publications

(16 citation statements)

References 37 publications

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“…In another study, it was found that Phellodendron amurense and Humulus japonicus extracts administered before preimplantation of cattle embryos contributed positively to blastocyst development by decreasing ROS levels (Do et al, 2017). In studies that favour our results, Mao et al (2018) stated that both MDA levels and oxidative stress would decrease by using plant‐derived antioxidants, while İnanç et al (2019) claimed that the antioxidant capacity of semen may be improved by utilising antioxidant supplements capable of reducing ROS levels in a semen extender. In a study on freezing of bull spermatozoa compatible with us, it was found that epicatechin, which is a type of natural antioxidant, relieves oxidative stress and improves sperm viability (Greifova, Tvrda, Jambor, & Lukac, 2017).…”

Section: Discussionmentioning

confidence: 66%

Red pine ( Pinus brutia Ten ) bark tree extract preserves sperm quality by reducing oxidative stress and preventing chromatin damage

et al. 2020

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This study aimed to investigate the effectiveness of using red pine bark tree extract (P; Pinus brutia Ten) as a TRIS extender in an attempt to prevent oxidative stress in bull spermatozoa after freezing. Semen specimens were obtained from Simmental bulls via an artificial vagina and pooled. They were separated into five specimens and diluted with Tris extender consisting of P (200, 100, 50 and 25 µg/ml) and P free (control; C) up to a final concentration of 16 × 106 per straw. All specimens were equilibrated for a period of 4 hr at a temperature of 4°C, following which they were filled in 0.25‐ml French straws and frozen. Addition of P resulted in favourable tail length in comparison with C (p < .05). The lowest malondialdehyde levels and the highest glutathione levels were detected in all P groups (p < .05). Supplementation with P did not show advanced results in terms of total, progressive sperm motility and total abnormality in comparison with C (p > .05). In conclusion, it has been shown that although P added to a Tris extender does not have a positive effect on sperm motility, it prevents chromatin damage by reducing oxidative stress, in addition to reducing head abnormalities when used at the amount of 50 μg/ml.

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Section: Discussionmentioning

confidence: 66%

Red pine ( Pinus brutia Ten ) bark tree extract preserves sperm quality by reducing oxidative stress and preventing chromatin damage

et al. 2020

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“…In addition, anthocyanin treatment during IVM improved developmental competence of SCNT embryos, most likely by increasing intracellular GSH synthesis, by reducing ROS level, and by stimulating nuclear reprogramming via increased transcription factor expression (You et al, 2010). Furthermore, quercetin was found to protect both goat sperm and preimplantation embryos from Cd 2+ ‐induced oxidative stress (Mao et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Procyanidin B1 promotes in vitro maturation of pig oocytes by reducing oxidative stress

Jin

Hao

Huang

et al. 2020

Molecular Reproduction Devel

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Oxidative stress negatively affects the in vitro maturation (IVM) of oocytes. Procyanidin B1 (PB1) is a natural polyphenolic compound that has antioxidant properties. In this study, we investigated the effect of PB1 supplementation during IVM of porcine oocytes. Treatment with 100 μM PB1 significantly increased the MII oocytes rate (p <0.05), the parthenogenetic (PA) blastocyst rate (p <0.01) and the total cell number in the PA blastocyst (p < 0.01) which were cultured in regular in vitro culture (IVC) medium. The PA blastocyst rate of regular MII oocytes activated and cultured in IVC medium supplemented with 100 and 150 μM PB1 significantly increased compared with control (p < 0.01 and p < 0.05). We also evaluated the reactive oxygen species (ROS) levels, mitochondrial membrane potential (Δψm) levels, glutathione (GSH) levels, and apoptotic levels in MII oocytes and cumulus cells following 100 μM PB1 treatment. The results showed that the PB1 supplementation decreased ROS production and apoptotic levels. In addition, PB1 was found to increase Δψm levels and GSH levels. In conclusion, PB1 inhibited apoptosis of oocytes and cumulus cells by reducing oxidative stress. Moreover, PB1 improved the quality of oocytes and promoted PA embryo development. Taken together, our results suggest that PB1 is a promising antioxidant additive for IVM of oocytes.

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“…The pathophysiological of toxic heavy metals result primarily from intensification of free radicals' production or weakening of the organism's defense mechanisms. The oxidative stress induced by toxic metals reduces the efficiency of the antioxidative defense system (reduced activity of antioxidative enzymes and endogenous non-enzymatic antioxidants, as well as reduced concentration of antioxidative vitamins), which results in damage to systems and organs [10,[61][62][63]. Toxic metals are not involved in Fenton's reactions, i.e., they do not directly rigger increased production of free radicals.…”

Section: Toxic Heavy Metalsmentioning

confidence: 99%

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

et al. 2020

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Neurodegenerative diseases are progressive diseases of the nervous system that lead to neuron loss or functional disorders. Neurodegenerative diseases require long-term, sometimes life-long pharmacological treatment, which increases the risk of adverse effects and a negative impact of pharmaceuticals on the patients' general condition. One of the main problems related to the treatment of this type of condition is the limited ability to deliver drugs to the brain due to their poor solubility, low bioavailability, and the effects of the blood-brain barrier. Given the above, one of the main objectives of contemporary scientific research focuses on the prevention of neurodegenerative diseases. As disorders related to the competence of the antioxidative system are a marker in all diseases of this type, the primary prophylactics should entail the use of exogenous antioxidants, particularly ones that can be used over extended periods, regardless of the patient's age, and that are easily available, e.g., as part of a diet or as diet supplements. The paper analyzes the significance of the oxidoreductive balance in the pathogenesis of neurodegenerative diseases. Based on information published globally in the last 10 years, an analysis is also provided with regard to the impact of exogenous antioxidants on brain functions with respect to the prevention of this type of diseases.

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Protective Effects of Quercetin Against Cadmium Chloride-Induced Oxidative Injury in Goat Sperm and Zygotes

Cited by 38 publications

References 37 publications

Red pine ( Pinus brutia Ten ) bark tree extract preserves sperm quality by reducing oxidative stress and preventing chromatin damage

Red pine ( Pinus brutia Ten ) bark tree extract preserves sperm quality by reducing oxidative stress and preventing chromatin damage

Procyanidin B1 promotes in vitro maturation of pig oocytes by reducing oxidative stress

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

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