Protective effects of propolis on female rats’ histopathological, biochemical and genotoxic changes during LPS induced endotoxemia

An important problem of treating patients with endotoxemia is to find drugs to reduce the negative effects of endotoxin on the organism. We tested fucoidan (sulfated polysaccharide) from the brown alga Fucus evanescens as a potential drug in a mouse model of endotoxemia inducted by lipopolysaccharide (LPS). The survival time of mice injected with LPS increased under fucoidan treatment compared with the group of mice injected with LPS only. The preventive administration of fucoidan to mice with endotoxemia resulted in inhibition of increased levels of proinflammatory cytokines (TNFα and IL-6), as well as decreasing of the processes of hypercoagulability. The parenteral or per os administration of fucoidan resulted in decreasing the degree of microcirculatory disorders and secondary dystrophic-destructive changes in parenchymal organs of mice with endotoxemia. Taken together, these results demonstrate that fucoidan prevents endotoxin-induced damage in a mouse model of endotoxemia and increases the mice’s resistance to LPS.

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“…Similar data, illustrating the LPS-induced damage in target organs, is shown in several studies [30,31,32]. …”

Section: Resultssupporting

confidence: 90%

Fucoidan Extracted from Fucus evanescens Prevents Endotoxin-Induced Damage in a Mouse Model of Endotoxemia

et al. 2014

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“…potential was experimentally investigated in treating or managing various diseases and injury conditions (4). The effectiveness of this product is essentially associated with its antioxidant and antitoxic functions.…”

Section: Resultsmentioning

confidence: 99%

In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

Baykara

Silici

Özçelik³

et al. 2015

Diagn Interv Radiol

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C ontrast agents are often used in diagnostic imaging or interventional procedures in clinical radiology or nuclear medicine for the purpose of providing contrast enhancement in images. Additional contrast improves the accuracy of detecting pathologic abnormalities in the underlying biological system or the outcome of the intervention. Some of the contrast agents, however, expose the patient to toxic side effects. Diatrizoate is one of those radiocontrast agents used for imaging kidney and its related structures. It has a high-osmolality and contains iodine for absorption of X-rays and hence for producing localized hyperintensities in computed tomography images. In patients with kidney dysfunction, as measured by serum creatinine clearance level of less than 60 mL/min, diatrizoate may lead to kidney failure (1). This effect is called contrast-induced nephropathy (CIN) and constitutes one of the most common causes of hospital-acquired renal failures in clinical practice. Therefore, it is important to develop preventive and/or protective strategies for safeguarding the kidney to be exposed to diatrizoate.Diatrizoate induces kidney damage through a combination of renal ischemia and direct toxic effect on renal tubular cells (2). The mechanism of pathogenesis includes factors such as impaired nitric oxide production, blockade of vasodilation and generation of reactive oxygen species, all promoting oxidative stress. For preventing kidney from acquiring CIN, past attempts were focused on interventions against toxicity and oxidative stress. In this regard, pharmaceuticals N-acetylcystein (NAC) and calpain inhibitor-1 were investigated and determined to be effective (3). As alternative to such man-made pharmaceuticals, natural compounds found in folk medicine have also gained popularity as viable options in health care. The natural product propolis has been explored on various fronts and its therapeutic

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“…BV has the ability to produce demethylation of promoter regions for the expression of genes related to cell survival [82]. Propolis, on the other hand, prevents DNA methylation [83].…”

Section: Loss Of Regulation Of Epigenetic Mechanismsmentioning

confidence: 99%

Apitherapy for Osteoarthritis: Perspectives from Basic Research

2020

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Osteoarthritis is one of the most common rheumatic disease in the world and one of the leading causes of disability in the elderly. There is still no curative management for the disease, so the search for new therapeutic alternatives continues. Apitherapy is a therapeutic tool based on the use of beehive products used since ancient times and, at present, their mechanism of action begins to be known. Many of the mechanisms of action of the beehive products are useful for chronic articular pathophysiological processes such as those described in osteoarthritis. This article presents a review of the current state of understanding of the mechanisms through which bee venom, propolis, honey, pollen, and royal jelly may act on osteoarthritis. © 2020 S. Karger AG, Basel Apitherapie bei Osteoarthritis: Perspektiven aus der GrundlagenforschungSchlüsselwörter Apitherapie · Osteoarthritis · Bienengift · Bienenprodukte · Komplementär-und Alternativmedizin ZusammenfassungOsteoarthritis ist eine der weltweit häufigsten rheumatischen Erkrankungen und eine der führenden Ursachen für körperliche Beeinträchtigung im Alter. Eine kurative Behandlungsoption steht bis heute nicht zur Verfügung, daher wird weiter nach therapeutischen Alternativen gesucht. Die Apitherapie ist ein therapeutisches Instrument, das auf der Anwendung von Bienenprodukten beruht, die seit dem Altertum verwendet werden und deren Wirkmechanismen wir gerade beginnen zu verstehen. Viele dieser Mechanismen, über die die Bienenprodukte ihre Wirkung entfalten, spielen eine nützliche Rolle in pathophysiologischen Prozessen von chronischen Gelenkerkrankungen wie zum Beispiel der Osteoarthritis. Dieser Artikel gibt einen Überblick über den aktuellen Kenntnisstand der Mechanismen, über die Bienengift, Propolis, Honig, Pollen und Gelée royale bei Osteoarthritis wirken könnten.

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Protective effects of propolis on female rats’ histopathological, biochemical and genotoxic changes during LPS induced endotoxemia

Cited by 24 publications

References 37 publications

Fucoidan Extracted from Fucus evanescens Prevents Endotoxin-Induced Damage in a Mouse Model of Endotoxemia

Fucoidan Extracted from Fucus evanescens Prevents Endotoxin-Induced Damage in a Mouse Model of Endotoxemia

In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

Apitherapy for Osteoarthritis: Perspectives from Basic Research

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