Protective effects of probucol in rats with postoperative acute renal failure*

Abstract

ObjectiveWe investigated the protective effect of probucol in rats with acute renal failure caused by various ischemia-reperfusion injuries (IRIs) after surgery.MethodsForty male Sprague-Dawley rats were randomly divided into a sham operation group (S group), ischemia reperfusion group (IR group), probucol low-dose treatment group (probucol + IR group 1, P+ IR 1 group; probucol 250 mg/kg intragastric administration daily), and probucol high-dose treatment group (P + IR 2 group; probucol 500 mg/kg intragastric administration daily). Rats in the S and IR groups were intragastrically administered with warm water every day. After 1 week, the kidney IRI rat models were prepared, after which the rats were fed for another week, and blood, urine, and the kidney tissue specimens were retained. A series of biochemical indices, superoxide dismutase (SOD), and malondialdehyde in the serum and kidney tissues were detected, and pathological changes in renal tissue were observed.ResultsTwenty-four-hour urinary protein excretion, urinary NAGase, CysC, blood urea nitrogen (BUN), and creatinine were significantly lower in the P + IR 1 and P + IR 2 groups than in the IR group (P < 0.05). Superoxide dismutase in the serum and renal tissue increased significantly, malondialdehyde decreased significantly (P < 0.05), renal pathological injury was alleviated, and the kidney index improved significantly (P < 0.05).ConclusionProbucol can relieve various types of acute renal failure in postoperative rats.