Protective effects of Poria cocos and its components against cisplatin-induced intestinal injury

Zou, Ye-Ting; Zhou, Jing; Wu, Cheng‐Ying; Zhang, Wei; Shen, Hong; Xu, Jin–Di; Zhang, Yeqing; Long, Fang; Li, Songlin

doi:10.1016/j.jep.2020.113722

Cited by 55 publications

(34 citation statements)

References 49 publications

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“…In contrast, acetic acid produced by the fermentation of Bifidobacterium can enhance the intestinal barrier and promote intestinal peristalsis, so as to inhibit the colonization of pathogenic bacteria and reduce the intake of toxins [ 60 ]. Prevotellaceae can reduce endothelial permeability, prevent the host from being exposed to endotoxins, and promote the improvement of intestinal function [ 61 ]. Ruminococcus_1 , which promotes the production of SCFAs, is beneficial to the growth of epithelial cells [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Zhao

Hou

et al. 2021

Nutrients

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Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat diet (HFD) have not been thoroughly studied. Mice were fed a low-fat diet, a HFD, and a HFD supplemented with 15% adzuki bean (HFD-AB) for 12 weeks. Adzuki bean supplementation significantly reduced obesity, lipid accumulation, and serum lipid and lipopolysaccharide (LPS) levels induced by HFD. It also mitigated liver function damage and hepatic steatosis. In particular, adzuki bean supplementation improved glucose homeostasis by increasing insulin sensitivity. In addition, it significantly reversed HFD-induced gut microbiota imbalances. Adzuki bean significantly reduced the ratio of Firmicutes/Bacteroidetes (F/B); enriched the occurrence of Bifidobacterium, Prevotellaceae, Ruminococcus_1, norank_f_Muribaculaceae, Alloprevotella, Muribaculum, Turicibacter, Lachnospiraceae_NK4A136_group, and Lachnoclostridium; and returned HFD-dependent taxa (Desulfovibrionaceae, Bilophila, Ruminiclostridium_9, Blautia, and Ruminiclostridium) back to normal status. PICRUSt2 analysis showed that the changes in gut microbiota induced by adzuki bean supplementation may be associated with the metabolism of carbohydrates, lipids, sulfur, and cysteine and methionine; and LPS biosynthesis; and valine, leucine, and isoleucine degradation.

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Section: Discussionmentioning

confidence: 99%

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Zhao

Hou

et al. 2021

Nutrients

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“…A Waters QTOF Synapt G2 mass spectrometer (Waters MS Technologies, Manchester, UK) was used for mass detection. Data processing methods were the same as those in our previous study ( 54 ). Briefly, peak finding, alignment, filtering, and normalization of raw data were performed using Masslynx v4.1 and Progenesis QI v2.0 (Waters Corporation, Milford, USA).…”

Section: Methodsmentioning

confidence: 99%

Gut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury

et al. 2022

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“…Among them, the main bioactive constituents are polysaccharides and triterpenes, which have been reported for various pharmacological benefits such as anti-inflammatory, antibacterial, antitumor and antioxidant effects. These pharmacological benefits contribute to the clinical efficacy of PC [ 17 , 18 , 19 , 20 ]. PC polysaccharides are a mixture of different types of polysaccharide, and account for 70~89% of the total dried mass of dried sclerotium, but only 2% of it dissolves in water—these water-soluble polysaccharides are the foundation of treating diseases, so PC is generally taken in the form of a water decoction [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of Cultivation Regions and Quality Parameters of Poria cocos by Near-Infrared Spectroscopy and Chemometrics

Xie

Huang

Ren

et al. 2022

Foods

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Poria cocos (PC) is an important fungus with high medicinal and nutritional values. However, the quality of PC is heavily dependent on multiple factors in the cultivation regions. Traditional methods are not able to perform quality evaluation for this fungus in a short time, and a new method is needed for rapid quality assessment. Here, we used near-infrared (NIR) spectroscopy combined with chemometric method to identify the cultivation regions and determine PC chemical compositions. In our study, 138 batches of samples were collected and their cultivation regions were distinguished by combining NIR spectroscopy and random forest method (RFM) with an accuracy as high as 92.59%. In the meantime, we used partial least square regression (PLSR) to build quantitative models and measure the content of water-soluble extract (WSE), ethanol-soluble extract (ASE), polysaccharides (PSC) and the sum of five triterpenoids (SFT). The performance of these models were verified with correlation coefficients (R2cal and R2pre) above 0.9 for the four quality parameters and the relative errors (RE) of PSC, WSE, ASE and SFT at 4.055%, 3.821%, 4.344% and 3.744%, respectively. Overall, a new approach was developed and validated which is able to distinguish PC production regions, quantify its chemical contents, and effectively evaluate PC quality.

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Protective effects of Poria cocos and its components against cisplatin-induced intestinal injury

Cited by 55 publications

References 49 publications

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Gut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury

Determination of Cultivation Regions and Quality Parameters of Poria cocos by Near-Infrared Spectroscopy and Chemometrics

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